Functional neuronal cells generated by human parthenogenetic stem cells

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Ahmad, Ruhel ^a   Wolber, Wanja ^a   Eckardt, Sigrid ^b   Koch, Philipp ^c   Schmitt, Jessica ^a   Semechkin, Ruslan ^d   Geis, Christian ^a   Heckmann, Manfred ^a   Brüstle, Oliver ^c   McLaughlin, John K ^b   Sirén, Anna Leena ^a   Müller, Albrecht M ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF BONN   (Germany)

^d INTERNATIONAL STEM CELL CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; GENOMIC DNA; MUSASHI1 PROTEIN; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX1; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; EMBRYONIC STEM CELL; EVOKED RESPONSE; FEMALE; FETUS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME ANALYSIS; GENOME IMPRINTING; GLIA CELL; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; PARTHENOGENESIS;

CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; DNA METHYLATION; DOPAMINERGIC NEURONS; ELECTROPHYSIOLOGICAL PHENOMENA; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOMIC IMPRINTING; HUMANS; MALE; MOTOR NEURONS; NEURAL STEM CELLS; NEUROGLIA; NEURONS; PARTHENOGENESIS;

EID: 84864654175     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042800     Document Type: Article

References (45)

1. Goldring CE, Duffy PA, Benvenisty N, Andrews PW, Ben-David U, et al. ((2011)) Assessing the safety of stem cell therapeutics. Cell Stem Cell 8: 618-628.
2. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, et al. ((1998)) Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147.
3. Yamanaka S, ((2007)) Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 1: 39-49.
4. Bock C, Kiskinis E, Verstappen G, Gu H, Boulting G, et al. ((2011)) Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell 144: 439-452.
5. Neaves WB, Baumann P, ((2011)) Unisexual reproduction among vertebrates. Trends Genet 27: 81-88.
6. Kono T, Obata Y, Wu Q, Niwa K, Ono Y, et al. ((2004)) Birth of parthenogenetic mice that can develop to adulthood. Nature 428: 860-864.
7. Kim K, Ng K, Rugg-Gunn PJ, Shieh JH, Kirak O, et al. ((2007)) Recombination signatures distinguish embryonic stem cells derived by parthenogenesis and somatic cell nuclear transfer. Cell Stem Cell 1: 346-352.
8. Mai Q, Yu Y, Li T, Wang L, Chen MJ, et al. ((2007)) Derivation of human embryonic stem cell lines from parthenogenetic blastocysts. Cell Res 17: 1008-1019.
9. Lin G, OuYang Q, Zhou X, Gu Y, Yuan D, et al. ((2007)) A highly homozygous and parthenogenetic human embryonic stem cell line derived from a one-pronuclear oocyte following in vitro fertilization procedure. Cell Res 17: 999-1007.
10. Revazova ES, Turovets NA, Kochetkova OD, Kindarova LB, Kuzmichev LN, et al. ((2007)) Patient-specific stem cell lines derived from human parthenogenetic blastocysts. Cloning Stem Cells 9: 432-449.
11. Choi SW, Eckardt S, Ahmad R, Wolber W, McLaughlin KJ, et al. ((2010)) Two paternal genomes are compatible with dopaminergic in vitro and in vivo differentiation. Int J Dev Biol 54: 1755-1762.
12. Dinger TC, Eckardt S, Choi SW, Camarero G, Kurosaka S, et al. ((2008)) Androgenetic embryonic stem cells form neural progenitor cells in vivo and in vitro. Stem Cells 26: 1474-1483.
13. Eckardt S, Leu NA, Bradley HL, Kato H, Bunting KD, et al. ((2007)) Hematopoietic reconstitution with androgenetic and gynogenetic stem cells. Genes Dev 21: 409-419.
14. Eckardt S, Leu NA, Yanchik A, Hatada S, Kyba M, et al. ((2011)) Gene therapy by allele selection in a mouse model of beta-thalassemia. J Clin Invest 121: 623-627.
15. Lengerke C, Kim K, Lerou P, Daley GQ, ((2007)) Differentiation potential of histocompatible parthenogenetic embryonic stem cells. Ann N Y Acad Sci 1106: 209-218.
16. Teramura T, Onodera Y, Murakami H, Ito S, Mihara T, et al. ((2009)) Mouse androgenetic embryonic stem cells differentiated to multiple cell lineages in three embryonic germ layers in vitro. J Reprod Dev 55: 283-292.
17. Wilkinson LS, Davies W, Isles AR, ((2007)) Genomic imprinting effects on brain development and function. Nat Rev Neurosci 8: 832-843.
18. Keverne EB, Fundele R, Narasimha M, Barton SC, Surani MA, ((1996)) Genomic imprinting and the differential roles of parental genomes in brain development. Brain Res Dev Brain Res 92: 91-100.
19. Gregg C, Zhang J, Weissbourd B, Luo S, Schroth GP, et al. ((2010)) High-resolution analysis of parent-of-origin allelic expression in the mouse brain. Science 329: 643-648.
20. Brevini TA, Pennarossa G, Antonini S, Paffoni A, Tettamanti G, et al. ((2009)) Cell lines derived from human parthenogenetic embryos can display aberrant centriole distribution and altered expression levels of mitotic spindle check-point transcripts. Stem Cell Rev 5: 340-352.
21. Chen Y, Ai A, Tang ZY, Zhou GD, Liu W, et al. ((2012)) Mesenchymal-like stem cells derived from human parthenogenetic embryonic stem cells. Stem Cells Dev 21: 143-151.
22. Harness JV, Turovets NA, Seiler MJ, Nistor G, Altun G, et al. ((2011)) Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells. PLoS One 6: e14499.
23. Isaev DA, Garitaonandia I, Abramihina TV, Zogovic-Kapsalis T, West RA, et al. ((2012)) In vitro differentiation of human parthenogenetic stem cells into neural lineages. Regen Med 7: 37-45.
24. Turovets N, Fair J, West R, Ostrowska A, Semechkin R, et al. ((2012)) Derivation of high-purity definitive endoderm from human parthenogenetic stem cells using an in vitro analog of the primitive streak. Cell Transplant 21: 217-234.
25. Wilkins JF, Ubeda F, ((2011)) Diseases associated with genomic imprinting. Prog Mol Biol Transl Sci 101: 401-445.
26. Koch P, Opitz T, Steinbeck JA, Ladewig J, Brustle O, ((2009)) A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc Natl Acad Sci U S A 106: 3225-3230.
27. Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, et al. ((2004)) Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci U S A 101: 12543-12548.
28. Li XJ, Du ZW, Zarnowska ED, Pankratz M, Hansen LO, et al. ((2005)) Specification of motoneurons from human embryonic stem cells. Nat Biotechnol 23: 215-221.
29. Kerjean A, Dupont JM, Vasseur C, Le Tessier D, Cuisset L, et al. ((2000)) Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis. Hum Mol Genet 9: 2183-2187.
30. Khoueiry R, Ibala-Rhomdane S, Mery L, Blachere T, Guerin JF, et al. ((2008)) Dynamic CpG methylation of the KCNQ1OT1 gene during maturation of human oocytes. J Med Genet 45: 583-588.
31. Rohde C, Zhang Y, Reinhardt R, Jeltsch A, ((2010)) BISMA-fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences. BMC Bioinformatics 11: 230.
32. Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, et al. ((2011)) Induction of human neuronal cells by defined transcription factors. Nature 476: 220-223.
33. Fitzpatrick GV, Soloway PD, Higgins MJ, ((2002)) Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet 32: 426-431.
34. Jinno Y, Sengoku K, Nakao M, Tamate K, Miyamoto T, et al. ((1996)) Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus. Hum Mol Genet 5: 1155-1161.
35. Conti L, Pollard SM, Gorba T, Reitano E, Toselli M, et al. ((2005)) Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol 3: e283.
36. Zhang SC, ((2006)) Neural subtype specification from embryonic stem cells. Brain Pathol 16: 132-142.
37. Kriegstein A, Alvarez-Buylla A, ((2009)) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32: 149-184.
38. Mann JR, Gadi I, Harbison ML, Abbondanzo SJ, Stewart CL, ((1990)) Androgenetic mouse embryonic stem cells are pluripotent and cause skeletal defects in chimeras: implications for genetic imprinting. Cell 62: 251-260.
39. Knoth R, Singec I, Ditter M, Pantazis G, Capetian P, et al. ((2010)) Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years. PLoS One 5: e8809.
40. Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, et al. ((2008)) Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol 26: 313-315.
41. Brevini TA, Pennarossa G, Maffei S, Tettamanti G, Vanelli A, et al. ((2012)) Centrosome Amplification and Chromosomal Instability in Human and Animal Parthenogenetic Cell Lines. Stem Cell Rev.
42. Humpherys D, Eggan K, Akutsu H, Hochedlinger K, Rideout WM 3rd, et al. ((2001)) Epigenetic instability in ES cells and cloned mice. Science 293: 95-97.
43. Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA, ((2005)) Epigenetic status of human embryonic stem cells. Nat Genet 37: 585-587.
44. Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA, ((2007)) Status of genomic imprinting in human embryonic stem cells as revealed by a large cohort of independently derived and maintained lines. Hum Mol Genet 16 Spec No. 2 pp. R243-251.
45. Reik W, Murrell A, ((2000)) Genomic imprinting. Silence across the border. Nature 405: 408-409.