Effect of calcium-vitamin D supplementation on metabolic profiles in pregnant women at risk for pre-eclampsia: A randomized placebo-controlled trial

Pakistan Journal of Biological Sciences

Volumn 15, Issue 7, 2012, Pages 316-324

  Asemi, Zatollah ^a   Tabassi, Zohreh ^a   Heidarzadeh, Zahra ^a   Khorammian, Hassan ^a   Sabihi, Sima Sadat ^a   Samimi, Mansooreh ^a  

^a KASHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Calcium vitamin D supplementation; FPG; Lipid profiles; Pre eclampsia; Pregnant women

Indexed keywords

BIOLOGICAL MARKER; CALCIUM CARBONATE; CHOLESTEROL; COLECALCIFEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ARTICLE; BLOOD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG COMBINATION; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; IRAN; METABOLISM; PREECLAMPSIA; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SINGLE BLIND PROCEDURE; THIRD TRIMESTER PREGNANCY; TIME; TREATMENT OUTCOME;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CALCIUM CARBONATE; CHOLECALCIFEROL; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY SUPPLEMENTS; DRUG COMBINATIONS; FEMALE; HUMANS; IRAN; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY TRIMESTER, THIRD; RISK FACTORS; SINGLE-BLIND METHOD; TIME FACTORS; TREATMENT OUTCOME; TRIGLYCERIDES; YOUNG ADULT;

EID: 84864649118     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2012.316.324     Document Type: Article

References (69)

1. Alvarez, J.A. and A. Ashraf, 2010. Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis. Int. J. Endocrinol., 10.1155/2010/351385.
2. Asemi, Z., S. Jazayeri, M. Najafi, M. Samimi and V. Mofid et al., 2011. Effects of daily consumption of probiotic yoghurt on inflammatory factors in pregnant women: A randomized controlled trial. Pak. J. Biol. Sci., 14: 476-482.
3. Bayhan, G., Y. Kocyigit, A. Atamer, Y. Atamer and Z. Akkus, 2005. Potential atherogenic roles of lipids, lipoprotein(a) and lipid peroxidation in preeclampsia. Gynecol. Endocrinol., 21: 1-6.
4. Belo, L., M. Caslake, D. Gaffney, A. Santos-Silva, L. Pereira-Leite, A. Quintanilha and I. Rebelo, 2002. Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies. Atherosclerosis, 162: 425-432.
5. Berends, A.L., C.J.M. de Groot, E.J. Sijbrands, M.P.S. Sie and S.H. Benneheij et al., 2008. Shared constitutional risks for maternal vascular-related pregnancy complications and future cardiovascular disease. Hypertension, 51: 1034-1041.
6. Brizzi, P., G. Tonolo, F. Esposito, L. Puddu, S. Dessole, M. Maioli and S. Milia, 1999. Lipoprotein metabolism during normal pregnancy. Am. J. Obstet. Gynecol., 181: 430-434.
7. Brown, L., B. Rosner, W.W. Willett and F.M. Sacks, 1999. Cholesterol-lowering effects of dietary fiber: A metaanalysis. Am. J. Clin. Nutr., 69: 30-42.
8. Carty, D.M., C. Delles and A.F. Dominiczak, 2010. Preeclampsia and future maternal health. J. Hypertens, 28: 1349-1355.
9. Cho, H.J., H.C. Kang, S.A. Choi, Y.C. Ju, H.S. Lee and H.J. Park, 2005. The possible role of Ca on the activation of microsomal triglyceride transfer protein in rat hepatocytes. Biol. Pharm. Bull., 28: 1418-1423.
10. Chung, M., E.M. Balk, M. Brendel, S. Ip and J. Lau et al., 2009. Vitamin D and calcium: A systematic review of health outcomes. Evidence Report/Technology Assessment No. 183, pp: 1-420.
11. De Boer, I.H., L.F. Tinker, S. Connelly, J.D. Curb and B.V. Howard et al., 2008. Calcium plus vitamin D supplementation and the risk of incident diabetes in the women's health initiative. Diabetes Care, 31: 701-707.
12. Devaraj, S., G. Jialal, T. Cook, D. Siegel and I. Jialal, 2011. Low vitamin D levels in Northern American adults with the metabolic syndrome. Hormone Metab. Res., 43: 72-74.
13. Duley, L., 2009. The global impact of pre-eclampsia and eclampsia. Semin. Perinatol., 33: 130-137.
14. Eftekhari, M.H., M. Akbarzadeh, M.H. Dabbaghmanesh and J. Hasanzadeh, 2011. Impact of treatment with oral calcitriol on glucose indices in type 2 diabetes mellitus patients. Asia Pac. J. Clin. Nutr., 20: 521-526.
15. Gagnon, C., Z.X. Lu, D.J. Magliano, D.W. Dunstan and J.E. Shaw et al., 2012. Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: Results from a national, population-based prospective study (The Australian diabetes, obesity and lifestyle study: AusDiab). J. Clin. Endocrinol. Metab. (In press).
16. Ghio, A., A. Bertolotto, V. Res I, L. Volpe and G. Di Cianm, 2011. Triglyceride metabolism in pregnancy. Adv. Clin. Chem., 55: 133-153.
17. Girouard, J., Y. Giguere, J.M. Moutquin and J.C. Forest, 2007. Previous hypertensive disease of pregnancy is associated with alterations of markers of insulin resistance. Hypertension, 49: 1056-1062.
18. Gupta, P., M. Narang, B.D. Banerjee and S. Bassi, 2004. Oxidative stress in term small for gestational age neonates born to undernourished mothers: A case control study. BMC Pediatrics, Vol. 4. 10.1186/1471-2431-4-14.
19. Hermansen, K., B. Hansen, R. Jacobsen, P. Clausen and M. Dalgaard et al., 2005. Effects of soy supplementation on blood lipids and arterial function inhypercholesterolaemic subjects. Eur. J. Clin. Nutr., 59: 843-850.
20. Horgan, R.P., D.I. Broadhurst, S.K. Walsh, W.B. Dunn and M. Brown et al., 2011. Metabolic profiling uncovers a phenotypic signature of small for gestational age in early pregnancy. J. Proteome Res., 10: 3660-3673.
21. Jahromi, A.S., P. Zareian and A. Madam, 2011a. Association of insulin resistance with serum interleukin-6 and TNF-a levels during normal pregnancy. Biomarker Insights, 6: 1-6.
22. Jahromi, A.S., P. Zareian and A. Madani, 2011 b. Insulin resistance and interleukin-1 a during normal pregnancy. Asian J. Biochem., 6: 366-372.
23. Jorde, R. and G. Grimnes, 2011. Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog. Lipid Res., 50: 303-312.
24. Jorde, R., M. Sneve, P. Torjesen and Y. Figenschau, 2010a. No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J. Internal Med., 267: 462-472.
25. Jorde, R., Y. Figenschau, M. Hutchinson, N. Emaus and O. Grimnes, 2010b. High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Eur. J. Clin. Nutr., 64: 1457-1464.
26. Karandish, M., S. Shockravi, M.T. Jalali and M.H. Haghighizadeh, 2009. Effect of calcium supplementation on lipid profile in overweight or obese Iranian women: A double-blind randomized clinical trial. Eur. J. Clin. Nutr., 63: 268-272.
27. Khattab, S., I.A. Mohsen, I. Aboul foutouh, H. S. Ashmawi and M.N. Mohsen et al., 2011. Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study. Gynecol. Endocrinol., 27: 789-793.
28. Khoury, J., T. Henriksen, I. Seljeflot, L. Morkrid, K.F. Froslie and S. Tonstad, 2007. Effects of an antiatherogenic diet during pregnancy on markers of maternal and fetal endothelial activation and inflammation: The CARRDIP study. BJOG:Int. J. Obstetrics Gynaecol., 114: 27 9-288.
29. Kirwan, J.P., S. Hauguel-De Mouzon, J. Lepereq, J.C. Challier and L. Huston-Presley et al., 2002. TNF-a is a predictor of insulin resistance in human pregnancy. Diabetes, 51: 2207-2213.
30. Kusters, D.M., S.J. Homsma, B.A. Hutten, M.T. Twickler, H.J. Avis, J.A. van der Post and E.S. Stroes, 2010. Dilemmas in treatment of women with familial hypercholesterolaemia during pregnancy. Neth. J. Med., 68: 299-303.
31. Lawlor, D.A., S.M. Morton, D. Nitsch and D.A. Leon, 2005. Association between childhood and adulthood socioeconomic position and pregnancy induced hypertension: Results from the Aberdeen children of the 1950s cohort study. J. Epidemiol. Community Health, 59: 49-55.
32. Li, Y., C. Wang, K. Zhu, R.N. Feng and C.H. Sun, 2010. Effects of multivitamin and mineral supplementation on adiposity, energy expenditure and lipid profiles in obese Chinese women. Int. J. Obesity, 34: 1070-1077.
33. Major, G.C., F. Alarie, J. Dore, S. Phouttama and A. Tremblay, 2007. Supplementation with calcium+ vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations. Am. J. Clin. Nutr., 85: 54-59.
34. Mankuta, D., M. Elami-Suzin, A. Elhayani and S. Vinker, 2010. Lipid profile in consecutive pregnancies. Lipids Health Dis., Vol. 9.
35. Maymone, A.C., J.P. Baillargeon, J. Menard and J.L. Ardilouze, 2011. Oral hypoglycemic agents for gestational diabetes mellitus? Expert Opin. Drug Saf., 10: 227-238.
36. Mehendale, S., A. Kilari, K. Dangat, V. Taralekar, S. Mahadik and S. Joshi, 2008. Fatty acids, antioxidants and oxidative stress in pre-eclampsia. Int. J. Gynaecol. Obstet., 100: 234-238.
37. Naharci, I., E. Bozoglu, N. Kocak, S. Doganci, H. Doruk and M. Serdar, 2011. Effect of vitamin D on insulin sensitivity in elderly patients with impaired fasting glucose. Geriatr. Gerontol. Int., 10.1111/j.1447-0594.2011.00791.x
38. Nakamura, Y., N. Okuda, T.C. Turin, A. Fujiyoshi, T. Okamura et al., 2010. Fatty acids intakes and serum lipid profiles: NIPPON DATA90 and the national nutrition monitoring. J Epidemiol., 20: S544-S548.
39. Ndububa, D.A., O.S. Ojo, V.A. Adetiloye, O. Rotimi, M.A. Durosinmi and L.O. Uchegbu, 1999. The incidence and characteristics of some paraneoplastic syndromes of hepatocellular carcinoma in Nigerian patients. Eur. J. Gastroenterol. Hepatol., 11: 1401-1404.
40. Pietrzak, A., J. Kadzielewski, K. Janowski, J. Rolinski and D. Krasowska et al., 2009. Lipoprotein (a) in patients with psoriasis: Associations with lipid profiles and disease severity. Int. J. Dermatol., 48: 379-387.
41. Pikilidou, M.I., AN. Lasaridis, P.A. Sarafidis, C.D. Befani and G.G. Koliakos et al., 2009. Insulin sensitivity increase after calcium supplementation and change in intraplatelet calcium and sodium-hydrogen exchange in hypertensive patients with type 2 diabetes. Diabetic Med., 26: 211-219.
42. Pittas, A.G., M. Chung, T. Trikalinos, J. Mitri and M. Brendel et al., 2010. Systematic review: Vitamin D and cardiometabolic outcomes. Ann. Internal Med., 152: 307-314.
43. Pittas, A.G., S.S. Harris, P.C. Stark and B. Dawson-Hughes, 2007. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care, 30: 980-986.
44. Ploumidou, K., A. Kyroudi-Voulgari, D. Perea, I. Anastasiou and D. Mitropoulos, 2010. Effect of a hypercholesterolemic diet on serum lipid profile, plasma sex steroid levels and prostate structure in rats. Urology, 76: 1517.el-1517.e5.
45. Reid, I.R. and M.J. Bolland, 2008. Calcium supplementation and vascular disease. Climacteric, 11: 280-286.
46. Reid, I.R., 2004. Effects of calcium supplementation on circulating lipids: Potential pharmacoeconomic implications. Drug Aging, 21: 7-17.
47. Ros, E. and J. Mataix, 2006. Fatty acid composition of nuts-implications for cardiovascular health. Br. J. Nutr., 96: S29-S35.
48. Rossner, S. and A. Ohlin, 1995. Pregnancy as a risk factor for obesity: Lessons from the Stockholm pregnancy and weight development study. Obesity Res., 3: 267s-275s.
49. Saleh, J., K. Cianflone, T. Chaudhary, H. Al-Riyami, A.R. Al-Abri and R. Bayoumi, 2007. Increased plasma acylation-stimulating protein correlates with hyperlipidemia at late gestation. Obesity, 15: 646-652.
50. Sanchez, M., A. de la Sierra, A. Coca, E. Poch, V. Giner and A. Urbano-Marquez, 1997. Oral calcium supplementation reduces intraplatelet free calcium concentration and insulin resistance in essential hypertensive patients. Hypertension, 29: 531-536.
51. Sankar, D., G. Sambandam, M.R. Rao and K.V. Pugalendi, 2005. Modulation of blood pressure, lipid profiles and redox status in hypertensive patients taking different edible oils. Clin. Chim. Acta, 355: 97-104.
52. Schleithoff, S.S., A. Zittermarm, G. Tenderich, H.K. Berthold, P. Stehle and R. Koerfer, 2006. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: A doubleblind, randomized, placebo-controlled trial. Am. J. Clin. Nutr., 83: 754-759.
53. Sibai, B.M., J. Heuth, S. Caritis, M.D. Lindheimer and C. MacPherson et al., 2000. Hypertensive disorders in twin versus singleton gestations. Am. J. Obstetrics Gynecol., 182: 938-942.
54. Solomon, C.G., J.S. Carroll, K. Okamura, S.W. Graves and E.W. Seely, 1999. Higher cholesterol and insulin levels in pregnancy are associated with increased risk for pregnancy-induced hypertension. Am. J. Hypertens, 12: 276-282.
55. Sudhakar, B., P. Kalaiarasi, K.S. Al-Numair, G. Chandramohan, R.K. Rao and K.V. Pugalendi, 2011. Effect of combination of edible oils on blood pressure, lipid profile, lipid peroxidative markers, antioxidant status and electrolytes in patients with hypertension on nifedipine treatment. Saudi Med. J., 32: 379-385.
56. Tai, K., A.G. Need, M. Horowitz and I.M. Chapman, 2008. Glucose tolerance and vitamin D: Effects of treating vitamin D deficiency. Nutrition, 24: 950-956.
57. Torres, D.D.O.C., A.C.O. Dos Santos, A.K.S.E. Silva, J.I.A. Leite, J.R.B. De Souza, E.I.C. Beltrao and C.A. Peixoto, 2010. Effect of maternal diet rich in omega-6 and omega-9 fatty acids on the liver of LDL receptor-deficient mouse offspring. Birth Defects Res. B: Dev. Reprod. Toxicol., 89: 164-170.
58. Uzan, J., M. Carbonnel, O. Piconne, R. Asmar and J.M. Ayoubi, 2011. Pre-eclampsia: Pathophysiology, diagnosis and management. Vase. Health Risk Manage., 7: 467-474.
59. Valdes, G., P. Kaufmann, J. Corthorn, R. Erices, K.B. Brosnihan and J. Joyner-Grantham, 2009. Vasodilator factors in the systemic and local adaptations to pregnancy. Reprod. Biol. Endocrinol., Vol. 7. 10.1186/1477-7827-7-79
60. Vaskonen, T., 2003. Dietary minerals and modification of cardiovascular risk factors. J. Nutr. Biochem., 14: 492-506.
61. Von Hurst, P.R., W. Stonehouse and J. Coad, 2010. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient: A randomised, placebo-controlled trial. Br. J. Nutr., 103: 549-555.
62. Wang, H., N. Xia, Y. Yang and D.Q. Peng, 2012. Influence of vitamin D supplementation on plasma lipid profiles: A meta-analysis of randomized controlled trials. Lipids Health Dis., Vol. 11. 10.1186/1476-511X-11-42
63. Wang, L., J.E. Manson, Y. Song and H.D. Sesso, 2010. Systematic review: Vitamin D and calcium supplementation in prevention of cardiovascular events. Ann. Internal Med., 152: 315-323.
64. Wehmeier, K., A. Beers, M.J. Haas, N.C. Wong, A. Steinmeyer, U. Zugel and A.D. Mooradian, 2005. Inhibition of apolipoprotein Al gene expression by 1, 25-dihydroxyvitamin D3. Biochim. Biophys. Acta (BBA)-Mol. Cell Biol. Lipids, 1737: 16-26.
65. Weisberg, S.P., D. McCann, M. Desai, M. Rosenbaum, R.L. Leibe and A.W. Ferrante Jr., 2003. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Inves., 112: 1796-1808.
66. Winkler, K., B. Wetzka, M.M. Hoffmann, I. Friedrich and M. Kinner et al., 2000. Low Density Lipoprotein (LDL) subfractions during pregnancy: Accumulation of buoyant LDL with advancing gestation. J. Clin. Endocrinol. Metab., 85: 4543-4550.
67. Zemel, M.B., H. Shi, B. Greer, D. DiRienzo and P.C. Zemel, 2000. Regulation of adiposity by dietary calcium. FASEB J., 14:1132-1138.
68. Zemel, M.B., W. Thompson, A. Milstead, K. Morris and P. Campbell, 2004. Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes. Res., 12: 582-590.
69. Zittermann, A., S.S. Schleithoff and R. Koerfer, 2005. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br. J. Nutr., 94: 483-492.