Antiviral activities of sulfonium-ion glucosidase inhibitors and 5-thiomannosylamine disaccharide derivatives against dengue virus

International Journal of Antimicrobial Agents

Volumn 40, Issue 3, 2012, Pages 273-276

  Mohan, Sankar ^a   McAtamney, Sarah ^b   Jayakanthan, Kumarasamy ^a   Eskandari, Razieh ^a   Von Itzstein, Mark ^b   Pinto, B Mario ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

5 Thiomannosylamine disaccharides; Dengue virus inhibition; Glucosidase inhibitor; N glycoprotein biosynthesis; N glycosylation; Sulfonium ions

Indexed keywords

1 DEOXYNOJIRIMYCIN; 5 THIOMANNOSYLAMINE DISACCHARIDE DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; ANTIVIRUS AGENT; CASTANOSPERMINE; DE O SULFONATED KOTALANOL; DE O SULFONATED PONKARANOL; DISACCHARIDE; KOTALANOL; OLIGOSACCHARIDE; RIBAVIRIN; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY TEST; DENGUE VIRUS; DRUG SCREENING; DRUG STRUCTURE; ENZYME GLYCOSYLATION; IC 50; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VERO CELL; VIRUS INHIBITION; VIRUS PURIFICATION;

ALPHA-GLUCOSIDASES; AMINO SUGARS; ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DENGUE VIRUS; DISACCHARIDES; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; SULFONIUM COMPOUNDS; VERO CELLS;

EID: 84864624213     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2012.05.002     Document Type: Article

References (17)

1. B.D. Lindenbach, and C.M. Rice Flaviviridae: the viruses and their replication D.M. Knipe, P.M. Howley, Field's virology 4th ed. 2001 Lippincott Williams and Wilkins Philadelphia, PA 991 1041
2. World Health Organization. Health topics: dengue. Geneva, Switzerland: WHO; 2011. http://www.who.int/topics/dengue/en/ [accessed 23.05.12].
3. World Health Organization. Dengue control: the virus. Geneva, Switzerland: WHO; 2011. http://www.who.int/denguecontrol/virus/en/ [accessed 23.05.12].
4. L.W. Ruddock, and M. Molinari N-glycan processing in ER quality control J Cell Sci 119 2006 4373 4380 (Pubitemid 44830636)
5. D.N. Hebert, B. Foellmer, and A. Helenius Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum Cell 81 1995 425 433
6. M.P. Courageot, M.P. Frenkiel, C.D. Dos Santos, V. Deubel, and P. Desprès α-Glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum J Virol 74 2000 564 572 (Pubitemid 30002943)
7. A.C. Sayce, J.L. Miller, and N. Zitzmann Targeting a host process as an antiviral approach against dengue virus Trends Microbiol 18 2010 323 330
8. B.D. Johnston, and B.M. Pinto Synthesis of 1,2- and 1,3-N-linked disaccharides of 5-thio-α-d-mannopyranose as potential inhibitors of the processing mannosidase class I and mannosidase II enzymes J Org Chem 63 1998 5797 5800 (Pubitemid 128491747)
9. B.D. Johnston, and B.M. Pinto Synthesis of heteroanalogues of disaccharides as potential inhibitors of the processing mannosidase class I enzymes Carbohydr Res 310 1998 17 25 (Pubitemid 28446183)
10. K. Jayakanthan, S. Mohan, and B.M. Pinto Structure proof and synthesis of kotalanol and de-O-sulfonated kotalanol, glycosidase inhibitors isolated from an herbal remedy for the treatment of type-2 diabetes J Am Chem Soc 131 2009 5621 5626
11. R. Eskandari, D.A. Kuntz, D.R. Rose, and B.M. Pinto Potent glucosidase inhibitors: de-O-sulfonated ponkoranol and its stereoisomer Org Lett 12 2010 1632 1635
12. W.F. Zandberg, S. Benjannet, J. Hamelin, B.M. Pinto, and N.G. Seidah N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1 Glycobiology 21 2011 1290 1300
13. W.F. Zandberg, N. Gao, J. Kumarasamy, M.A. Lehrman, N.G. Seidah, and B.M. Pinto 5-Thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation Chembiochem 13 2012 392 401
14. K. Jones, L. Sim, S. Mohan, J. Kumarasamy, H. Liu, and S. Avery Mapping the intestinal α-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase Bioorg Med Chem 19 2011 3929 3934
15. B.L. Cantarel, P.M. Coutinho, C. Rancurel, T. Bernard, V. Lombard, and B. Henrissat The Carbohydrate-Active EnZymes database (CAZy): an expert resource for glycogenomics Nucleic Acids Res 37 Database issue 2009 D233 D238
16. A.F. Payne, I. Binduga-Gajewska, E.B. Kauffman, and L.D. Kramer Quantitation of flaviviruses by fluorescent focus assay J Virol Methods 134 2006 183 189
17. Y. Modis, S. Ogata, D. Clements, and S.C. Harrison Structure of the dengue virus envelope protein after membrane fusion Nature 427 2004 313 319 (Pubitemid 38133652)