Advantages and disadvantages of etomidate use for intubation of patients with sepsis

Pharmacotherapy

Volumn 32, Issue 5, 2012, Pages 475-482

  Cherfan, Antoine J ^a   Arabi, Yaseen M ^b,c,d   Al Dorzi, Hasan M ^b,d   Kenny, Lisa P ^e  

^a Pharmaceutical Care Department   (United States)

^b Intensive Care Department   (United States)

^c Respiratory Services   (United States)

^d KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Etomidate; Hydrocortisone; Intubation; Mortality; Relative adrenal insufficiency; Sepsis

Indexed keywords

CORTICOSTEROID; ETOMIDATE; FLUDROCORTISONE; HYDROCORTISONE; KETAMINE; MIDAZOLAM; MORPHINE; PLACEBO; PROPOFOL; STEROID; THIOPENTAL;

ADRENAL INSUFFICIENCY; CLINICAL EFFECTIVENESS; CONTINUOUS INFUSION; CORTICOSTEROID THERAPY; DISEASE ASSOCIATION; DISEASE DURATION; DISEASE SEVERITY; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG FATALITY; DRUG HALF LIFE; DRUG INDICATION; DRUG POTENCY; DRUG SAFETY; EVIDENCE BASED MEDICINE; HEMODYNAMIC MONITORING; HICCUP; HUMAN; HYPOTENSION; INJECTION SITE PAIN; MYOCLONUS; NONHUMAN; OUTCOME ASSESSMENT; RESPIRATORY TRACT INTUBATION; REVIEW; SEPSIS; SEPTIC SHOCK; SINGLE DRUG DOSE; SURVIVAL RATE; TREATMENT DURATION; VOMITING;

ADRENAL INSUFFICIENCY; CLINICAL TRIALS AS TOPIC; ETOMIDATE; HUMANS; HYPNOTICS AND SEDATIVES; INTUBATION, INTRATRACHEAL; SEPSIS; TREATMENT OUTCOME;

EID: 84864621717     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1875-9114.2012.01027.x     Document Type: Review

References (42)

1. Bergen JM, Smith DC. A review of etomidate for rapid sequence intubation in the emergency department. J Emerg Med 1997;15:221-30.
2. McCollum JS, Dundee JW. Comparison of induction characteristics of four intravenous anaesthetic agents. Anaesthesia 1986;41:995-1000.
3. Zed PJ, Abu-Laban RB, Harrison DW. Intubating conditions and hemodynamic effects of etomidate for rapid sequence intubation in the emergency department: An observational cohort study. Acad Emerg Med 2006;13:378-83.
4. Vinclair M, Broux C, Faure P, et al. Duration of adrenal inhibition following a single dose of etomidate in critically ill patients. Intensive Care Med 2008;34:714-9.
5. Bloomfield R, Noble DW. Etomidate and fatal outcome-even a single bolus dose may be detrimental for some patients. Br J Anaesth 2006;97:116-7.
6. Tekwani KL, Watts HF, Sweis RT, et al. A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: A prospective, randomized study. Ann Emerg Med 2010;56:481-9.
7. Dmello D, Taylor S, O'Brien J, et al. Outcomes of etomidate in severe sepsis and septic shock. Chest 2010;138:1327-32.
8. Annane D, Sebille V, Troche G, et al. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000;283:1038-45.
9. Giese JL, Stanley TH. Etomidate: A new intravenous anesthetic induction agent. Pharmacotherapy 1983;3:251-8.
10. Zed PJ, Mabasa VH, Slavik RS, et al. Etomidate for rapid sequence intubation in the emergency department: Is adrenal suppression a concern? CJEM 2006;8:347-50.
11. Baird CR, Hay AW, McKeown DW, et al. Rapid sequence induction in the emergency department: Induction drug and outcome of patients admitted to the intensive care unit. Emerg Med J 2009;26:576-9.
12. Sakles JC, Laurin EG, Rantapaa AA, et al. Airway management in the emergency department: A one-year study of 610 tracheal intubations. Ann Emerg Med 1998;31:325-32.
13. Criado A, Maseda J, Navarro E, et al. Induction of anaesthesia with etomidate: Haemodynamic study of 36 patients. Br J Anaesth 1980;52:803-6.
14. Doenicke AW, Roizen MF, Kugler J, et al. Reducing myoclonus after etomidate. Anesthesiology 1999;90:113-9.
15. Jones AE, Yiannibas V, Johnson C, et al. Emergency department hypotension predicts sudden unexpected in-hospital mortality: A prospective cohort study. Chest 2006;130:941-6.
16. Edwards JP, Green RS. Severe hypotension following endotracheal intubation [abstract]. Can J Emerg Med 2006;8(3):210-1.
17. Patschke D, Bruckner JB, Gethmann JW, et al. Comparison of the immediate effects of etomidate, propanidid and thiopentone on haemodynamics, coronary bloodflow and myocardial oxygen consumption. Acta Anaesthesiol Belg 1975;26:112-9.
18. Gooding JM, Corssen G. Etomidate: An ultrashort-Acting nonbarbiturate agent for anesthesia induction. Anesth Analg 1976;55:286-9.
19. Paris A, Philipp M, Tonner PH, et al. Activation of alpha 2Badrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology 2003;99:889-95.
20. Ray DC, McKeown DW. Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. Crit Care 2007;11:R56.
21. Jabre P, Combes X, Lapostolle F, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: A multicentre randomised controlled trial. Lancet 2009;374:293-300.
22. Mort TC. Complications of emergency tracheal intubation: Hemodynamic alterations-part I. J Intensive Care Med 2007;22:157-65.
23. Annane D. ICU physicians should abandon the use of etomidate Intensive Care Med 2005;31:325-6.
24. Wagner RL, White PF, Kan PB, et al. Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 1984;310:1415-21.
25. Duthie DJ, Fraser R, Nimmo WS. Effect of induction of anaesthesia with etomidate on corticosteroid synthesis in man. Br J Anaesth 1985;57:156-9.
26. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008;34: 17-60.
27. Bollaert PE, Fieux F, Charpentier C, et al. Baseline cortisol levels, cortisol response to corticotropin, and prognosis in late septic shock. Shock 2003;19:13-5.
28. Ledingham IM, Watt I. Influence of sedation on mortality in critically ill multiple trauma patients. Lancet 1983;1:1270.
29. Hohl CM, Kelly-Smith CH, Yeung TC, et al. The effect of a bolus dose of etomidate on cortisol levels, mortality, and health services utilization: A systematic review. Ann Emerg Med 2010;56:105-113 e105
30. Mohammad Z, Afessa B, Finkielman JD. The incidence of relative adrenal insufficiency in patients with septic shock after the administration of etomidate. Crit Care 2006;10:R105.
31. Edwin SB, Walker PL. Controversies surrounding the use of etomidate for rapid sequence intubation in patients with suspected sepsis. Ann Pharmacother 2010;44:1307-13.
32. Malerba G, Romano-Girard F, Cravoisy A, et al. Risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation. Intensive Care Med 2005;31:388-92.
33. Cuthbertson BH, Sprung CL, Annane D, et al. The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 2009;35:1868-76.
34. Bloomfield R, Noble D. Etomidate and intensive care physicians. Intensive Care Med 2005;31:1453; author reply 1454.
35. Mongardon N, Singer M. Etomidate versus ketamine for sedation in acutely ill patients. Lancet 2009;374:1240; author reply 1241.
36. Albert SG, Ariyan S, Rather A. The effect of etomidate on adrenal function in critical illness: A systematic review. Intensive Care Med 2011;37:901-10.
37. Absalom A, Pledger D, Kong A. Adrenocortical function in critically ill patients 24 h after a single dose of etomidate. Anaesthesia 1999;54:861-7.
38. Hildreth AN, Mejia VA, Maxwell RA, et al. Adrenal suppression following a single dose of etomidate for rapid sequence induction: A prospective randomized study. J Trauma 2008;65:573-9.
39. Schenarts CL, Burton JH, Riker RR. Adrenocortical dysfunction following etomidate induction in emergency department patients. Acad Emerg Med 2001;8:1-7.
40. Jacoby J, Heller M, Nicholas J, et al. Etomidate versus midazolam for out-of-hospital intubation: A prospective, randomized trial. Ann Emerg Med 2006;47:525-30.
41. Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862-71.
42. Annane D. Etomidate and intensive care physicians. Intensive Care Med 2005;31:1454.