Outcomes of etomidate in severe sepsis and septic shock

Chest

Volumn 138, Issue 6, 2010, Pages 1327-1332

  Dmello, Dayton ^a   Taylor, Stephen ^b   O'Brien, Jacklyn ^b   Matuschak, George M ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST JOHN S MERCY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; ETOMIDATE; HYPERTENSIVE FACTOR;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; FEMALE; HUMAN; INTENSIVE CARE UNIT; INTUBATION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; SCORING SYSTEM; SEPSIS; SEPTIC SHOCK; SINGLE DRUG DOSE; TERTIARY HEALTH CARE; TREATMENT OUTCOME; UNIVERSITY HOSPITAL;

EID: 78649823342     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.10-0790     Document Type: Article

References (37)

1. Fengler BT. Should etomidate be used for rapid-sequence intubation induction in critically ill septic patients? Am J Emerg Med. 2008;26(2):229-232.
2. Ledingham IM, Watt I. Influence of sedation on mortality in critically ill multiple trauma patients. Lancet. 1983;1(8336):1270.
3. Jackson WL Jr. Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock? A critical appraisal. Chest. 2005;127(3):1031-1038.
4. Marik PE, Pastores SM, Annane D, et al; American College of Critical Care Medicine. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med. 2008;36(6):1937-1949.
5. Annane D, Sébille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002;288(7):862-871.
6. Mokhlesi B. Corticosteroids for patients with septic shock. JAMA. 2003;289(1):43-44.
7. Walls RM, Osborn TM. Special report: should etomidate be used as an induction agent for patients with sepsis? Journal Watch Emergency Medicine. February 1, 2008.
8. Ray DC, McKeown DW. Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. Crit Care. 2007;11(3):R56.
9. Tekwani KL, Watts HF, Chan CW, Nanini S, Rzechula KH, Kulstad EB. The effect of single-bolus etomidate on septic patient mortality: a retrospective review. West J Emerg Med. 2008;9(4):195-200.
10. Lipiner-Friedman D, Sprung CL, Laterre PF, et al; Corticus Study Group. Adrenal function in sepsis: the retrospective Corticus cohort study. Crit Care Med. 2007;35(4):1012-1018.
11. Cuthbertson BH, Sprung CL, Annane D, et al. The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med. 2009;35(11):1868-1876.
12. Hildreth AN, Mejia VA, Maxwell RA, Smith PW, Dart BW, Barker DE. Adrenal suppression following a single dose of etomidate for rapid sequence induction: a prospective randomized study. J Trauma. 2008;65(3):573-579.
13. Baird CR, Hay AW, McKeown DW, Ray DC. Rapid sequence induction in the emergency department: induction drug and outcome of patients admitted to the intensive care unit. Emerg Med J. 2009;26(8):576-579.
14. Jabre P, Combes X, Lapostolle F, et al; KETASED Collaborative Study Group. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet. 2009;374(9686):293-300.
15. Dmello D, Taylor S, O'Brien J, et al. ICU physicians should not abandon the use of etomidate! Crit Care Med. 2006;34(12)(suppl):A110.
16. Bone RC, Balk RA, Cerra FB, et al; The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 1992;101(6):1644-1655.
17. Vinclair M, Broux C, Faure P, et al. Duration of adrenal inhibition following a single dose of etomidate in critically ill patients. Intensive Care Med. 2008;34(4):714-719.
18. Bloomfield R, Noble DW. Etomidate and fatal outcome - even a single bolus dose may be detrimental for some patients. Br J Anaesth. 2006;97(1):116-117.
19. Dellinger RP, Levy MM, Carlet JM, et al; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36(1):296-327.
20. Kamp R, Kress JP. Etomidate, sepsis, and adrenal function: not as bad as we thought? Crit Care. 2007;11(3):145.
21. Cooper MS, Stewart PM. Adrenal insufficiency in critical illness. J Intensive Care Med. 2007;22(6):348-362.
22. Mohammad Z, Afessa B, Finkielman JD. The incidence of relative adrenal insufficiency in patients with septic shock after the administration of etomidate. Crit Care. 2006;10(4):R105.
23. Cotton BA, Guillamondegui OD, Fleming SB, et al. Increased risk of adrenal insufficiency following etomidate exposure in critically injured patients. Arch Surg. 2008;143(1):62-67.
24. Malerba G, Romano-Girard F, Cravoisy A, et al. Risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation. Intensive Care Med. 2005;31(3):388-392.
25. den Brinker M, Joosten KF, Liem O, et al. Adrenal insuf- ficiency in meningococcal sepsis: bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality. J Clin Endocrinol Metab. 2005;90(9):5110-5117.
26. Crozier TA. Fatal flaws in the case against etomidate for induction [e-letter]. Br J Anaesth. 2006.
27. Sprung CL, Annane D, Keh D, et al; CORTICUS Study Group. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358(2):111-124.
28. Walls RM, Murphy MF. Clinical controversies: etomidate as an induction agent for endotracheal intubation in patients with sepsis: continue to use etomidate for intubation of patients with septic shock. Ann Emerg Med. 2008;52(1):13-14.
29. Sacchetti A. Etomidate: not worth the risk in septic patients. Ann Emerg Med. 2008;52(1):14-16.
30. Murray H, Marik PE. Etomidate for endotracheal intubation in sepsis: acknowledging the good while accepting the bad. Chest. 2005;127(3):707-709.
31. Annane D. ICU physicians should abandon the use of etomidate! Intensive Care Med. 2005;31(3):325-326.
32. Kim TY, Rhee JE, Kim KS, Cha WC, Suh GJ, Jung SK. Etomidate should be used carefully for emergent endotracheal intubation in patients with septic shock. J Korean Med Sci. 2008;23(6):988-991.
33. Bloomfield R, Noble D. Etomidate and intensive care physicians. Intensive Care Med. 2005;31(10):1453.
34. Annane D. Etomidate and Intensive care physicians. Intensive Care Med. 2005;31(10): 1454.
35. Zed PJ, Mabasa VH, Slavik RS, Abu-Laban RB. Etomidate for rapid sequence intubation in the emergency department: is adrenal suppression a concern? CJEM. 2006;8(5):347-350.
36. Dmello D, O'Brien J. The role of steroids with etomidate use during intubation in severe sepsis [abstract]. Am J Respir Crit Care Med. 2008;177:A126.
37. Kulstad EB. (2007). The effect of etomidate on patient outcomes after single bolus doses. http://www.clinicaltrials.gov/ct2/show/NCT00441792. Accessed January 29, 2010.