A strategy for promoting bone regeneration by inducible expression of 15-LOX-1

Medical Hypotheses

Volumn 79, Issue 3, 2012, Pages 413-414

  Pang, Hao ^a   Wu, Xue Hui ^a   Xu, Jian Zhong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

15 LIPOXYGENASE TYPE 1; ARACHIDONATE 15 LIPOXYGENASE; PROTEIN P21; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE REGENERATION; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; GROWTH INHIBITION; HYPOTHESIS; NONHUMAN; OSSIFICATION; OSTEOBLAST; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RABBIT; RECEPTOR DOWN REGULATION;

ARACHIDONATE 15-LIPOXYGENASE; BONE REGENERATION; HUMANS; MODELS, THEORETICAL;

EID: 84864608599     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.06.010     Document Type: Article

References (17)

1. Bedelbaeva K., Snyder A., Gourevitch D., Clark L., Zhang X.M., Leferovich J., et al. Lack of p21 expression links cell cycle control and appendage regeneration in mice. Proc Natl Acad Sci USA 2010, 107(13):5845-5850.
2. Menger B., Vogt P.M., Allmeling C., Radtke C., Kuhbier J.W., Reimers K. AmbLOXe-an epidermal lipoxygenase of the Mexican axolotl in the context of amphibian regeneration and its impact on human wound closure in vitro. Ann Surg 2011, 253(2):410-418.
3. Giannoudis P.V., Faour O., Goff T., Kanakaris N., Dimitriou R. Masquelet technique for the treatment of bone defects: tips-tricks and future directions. Injury 2011, 42(6):591-598.
4. Arvidson K., Abdallah B.M., Applegate L.A., Baldini N., Cenni E., Gomez-Barrena E., et al. Bone regeneration and stem cells. J Cell Mol Med 2011, 15(4):718-746.
5. Fernando W.A., Leininger E., Simkin J., Li N., Malcom C.A., Sathyamoorthi S., et al. Wound healing and blastema formation in regenerating digit tips of adult mice. Dev Biol 2011, 350(2):301-310.
6. Porrello E.R., Mahmoud A.I., Simpson E., Hill J.A., Richardson J.A., Olson E.N., et al. Transient regenerative potential of the neonatal mouse heart. Science 2011, 331(6020):1078-1080.
7. Yakushiji N., Yokoyama H., Tamura K. Repatterning in amphibian limb regeneration: a model for study of genetic and epigenetic control of organ regeneration. Semin Cell Dev Biol 2009, 20(5):565-574.
8. Chadwick R.B., Bu L.M., Yu H.R., Hu Y., Wergedal J.E., Mohan S., et al. Digit tip regrowth and differential gene expression in MRL/Mpj, DBA/2, and C57BL/6 mice. Wound Repair Regen 2007, 15(2):275-284.
9. Pallas M., Verdaguer E., Jorda E.G., Jimenez A., Canudas A.M., Camins A. Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases. Med Hypotheses 2005, 64(1):120-123.
10. Bellosta P., Masramon L., Mansukhani A., Basilico C. P21(WAF1/CIP1) acts as a brake in osteoblast differentiation. J Bone Miner Res 2003, 18(5):818-826.
11. Yoshinaga M., Buchanan F.G., DuBois R.N. 15-LOX-1 inhibits p21 (Cip/WAF1) expression by enhancing MEK-ERK1/2 signaling in colon carcinoma cells. Prostag Oth Lipid M 2004, 73(1-2):111-122.
12. Deliri H., Meller N., Kadakkal A., Malhotra R., Brewster J., Doran A.C., et al. Increased 12/15-lipoxygenase enhances cell growth, fibronectin deposition, and neointimal formation in response to carotid injury. Arterioscler Thromb Vasc Biol 2011, 31(1):110-116.
13. Klein R.F., Allard J., Avnur Z., Nikolcheva T., Rotstein D., Carlos A.S., et al. Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 2004, 303(5655):229-232.
14. Mullin B.H., Spector T.D., Curtis C.C., Ong G.N., Hart D.J., Hakim A.J., et al. Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. Calcified Tissue Int 2007, 81(1):10-17.
15. Harslof T., Husted L.B., Nyegaard M., Carstens M., Stenkjaer L., Brixen K., et al. Polymorphisms in the ALOX12 gene and osteoporosis. Osteoporos Int 2011, 22(8):2249-2259.
16. Ichikawa S., Koller D.L., Johnson M.L., Lai D., Xuei X., Edenberg H.J., et al. Human ALOX12, but not ALOX15, is associated with BMD in white men and women. J Bone Miner Res 2006, 21(4):556-564.
17. Serhan C.N., Jain A., Marleau S., Clish C., Kantarci A., Behbehani B., et al. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol 2003, 171(12):6856-6865.