The pathogenesis of systemic sclerosis revisited

Clinical Reviews in Allergy and Immunology

Volumn 40, Issue 2, 2011, Pages 92-103

  Geyer, Matthias ^a   Müller Ladner, Ulf ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Angiopathy; Collagen; Extracellular matrix; Immune; Pathophysiology; Systemic sclerosis; Vasculature

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIN 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA; UROKINASE; UROKINASE RECEPTOR; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; VON WILLEBRAND FACTOR;

ARTHRALGIA; ARTICLE; AUTOIMMUNITY; CELLULAR IMMUNITY; DYSPAREUNIA; DYSPEPSIA; DYSPHAGIA; DYSPNEA; ERECTILE DYSFUNCTION; GASTROESOPHAGEAL REFLUX; HUMAN; HUMORAL IMMUNITY; KIDNEY FAILURE; PATHOGENESIS; PATHOPHYSIOLOGY; PULMONARY HYPERTENSION; SYNCOPE; SYNDROME CREST; SYSTEMIC SCLEROSIS; VASCULAR DISEASE;

ANIMALS; AUTOIMMUNITY; FIBROSIS; HUMANS; INFLAMMATION; LYMPHOCYTES; SCLERODERMA, SYSTEMIC; VASCULAR DISEASES;

EID: 79951670868     PISSN: 10800549     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12016-009-8193-3     Document Type: Article

References (109)

1. C Lunardi M Dolcino D Peterlana, et al. 2006 Antibodies against human cytomegalovirus in the pathogenesis of systemic sclerosis: a gene array approach PLoS Med 3 e2 16318412
2. A Kahan CJ Menkes B Amor 1986 Defective Epstein-Barr virus specific suppressor T cell function in progressive systemic sclerosis Ann Rheum Dis 45 553 560 1:STN:280:DyaL283psVOmuw%3D%3D 3017245 (Pubitemid 16066079)
3. K Zakrzewska F Corcioli KM Carlsen, et al. 2009 Human parvovirus B19 (B19V) infection in systemic sclerosis patients Intervirology 52 279 282 19672101
4. T Ohtsuka S Yamazaki 2004 Increased prevalence of human parvovirus B19 DNA in systemic sclerosis skin Br J Dermatol 150 1091 1095 1:CAS:528: DC%2BD2cXmslCit78%3D 15214893 (Pubitemid 38932277)
5. RI Fox HI Kang 1992 Genetic and environmental factors in systemic sclerosis Curr Opin Rheumatol 4 857 861 1:STN:280:DyaK3s%2FptVGruw%3D%3D 1457281
6. MH Rustin HA Bull V Ziegler, et al. 1990 Silica-associated systemic sclerosis is clinically, serologically and immunologically indistinguishable from idiopathic systemic sclerosis Br J Dermatol 123 725 734 1:STN:280:DyaK3M%2FptFWrsg%3D%3D 2176091
7. N Calvani F Silvestris F Dammacco 2001 Familial systemic sclerosis following exposure to organic solvents and the possible implication of genetic factors Ann Ital Med Int 16 175 178 1:STN:280:DC%2BD3MnjslWrsg%3D%3D 11692907
8. AM Garcia-Zamalloa E Ojeda C Gonzalez-Beneitez J Goni A Garrido 1994 Systemic sclerosis and organic solvents: early diagnosis in industry Ann Rheum Dis 53 618 1:STN:280:DyaK2M%2FntVekug%3D%3D 7979602 (Pubitemid 24302321)
9. Y Allanore J Wipff A Kahan C Boileau 2007 Genetic basis for systemic sclerosis Joint Bone Spine 74 577 583 1:CAS:528:DC%2BD1cXitlGku7s%3D 17855142 (Pubitemid 350245624)
10. P Dieude M Guedj J Wipff, et al. 2009 STAT4 is a genetic risk factor for systemic sclerosis having additive effects with IRF5 on disease susceptibility and related pulmonary fibrosis Arthritis Rheum 60 2472 2479 1:CAS:528: DC%2BD1MXhtV2hsLfK 19644887
11. FK Tan FC Arnett 2000 Genetic factors in the etiology of systemic sclerosis and Raynaud phenomenon Curr Opin Rheumatol 12 511 519 1:CAS:528:DC%2BD3cXosVejsbs%3D 11092201
12. G Fantonetti 1838 Case of general induration of the skin Dublin J Med Sci 13 158 159
13. RH Goetz 1945 The pathology of progressive systemic sclerosis (generalised scleroderma) with special reference to changes in the viscera Clin Proc J Cape Town Postgrad Med Ass 4 337 341
14. EC LeRoy C Black R Fleischmajer, et al. 1988 Scleroderma (systemic sclerosis): classification, subsets and pathogenesis J Rheumatol 15 202 205 1:STN:280:DyaL1c3gtVWnsg%3D%3D 3361530 (Pubitemid 18073738)
15. MB Kahaleh 2004 Raynaud phenomenon and the vascular disease in scleroderma Curr Opin Rheumatol 16 718 722 15577610 (Pubitemid 39425545)
16. A Scheja A Akesson P Geborek, et al. 2001 Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma) Arthritis Res 3 178 182 1:CAS:528:DC%2BD3MXjsFOmsb4%3D 11299058 (Pubitemid 32303434)
17. M Matucci-Cerinic U Pietrini S Marabini 1990 Local venomotor response to intravenous infusion of substance P and glyceryl trinitrate in systemic sclerosis Clin Exp Rheumatol 8 561 565 1:STN:280:DyaK3M7ks1WgtA%3D%3D 1705189
18. MM Cerinic G Valentini GG Sorano, et al. 2003 Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis Semin Arthritis Rheum 32 285 295 1:CAS:528:DC%2BD3sXjvFejt7Y%3D 12701039 (Pubitemid 36459278)
19. NJ McHugh O Distler R Giacomelli G Riemekasten 2003 Non organ based laboratory markers in systemic sclerosis Clin Exp Rheumatol 21 S32 S38 1:STN:280:DC%2BD3szlslaitQ%3D%3D 12889220
20. R Sgonc MS Gruschwitz H Dietrich H Recheis ME Gershwin G Wick 1996 Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma J Clin Invest 98 785 792 1:CAS:528:DyaK28XkvVeis7g%3D 8698871 (Pubitemid 26349184)
21. AD Cambrey NK Harrison KE Dawes, et al. 1994 Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro Am J Respir Cell Mol Biol 11 439 445 1:CAS:528:DyaK2cXmslyisr4%3D 7917311
22. J Varga D Abraham 2007 Systemic sclerosis: a prototypic multisystem fibrotic disorder J Clin Invest 117 557 567 1:CAS:528:DC%2BD2sXis12htrw%3D 17332883 (Pubitemid 46348510)
23. M Humbert NW Morrell SL Archer, et al. 2004 Cellular and molecular pathobiology of pulmonary arterial hypertension J Am Coll Cardiol 43 13S 24S 1:CAS:528:DC%2BD2cXlsFyhtrs%3D 15194174 (Pubitemid 38759713)
24. EC LeRoy 1996 Systemic sclerosis. A vascular perspective Rheum Dis Clin North Am 22 675 694 1:STN:280:DyaK2s%2Fot1enug%3D%3D 8923590
25. JH Park YK Sung SC Bae SY Song HS Seo JB Jun 2009 Ulnar artery vasculopathy in systemic sclerosis Rheumatol Int 29 1081 1086 19363679
26. CD Cool JS Stewart P Werahera, et al. 1999 Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers. Evidence for a dynamic and heterogeneous process of pulmonary endothelial cell growth Am J Pathol 155 411 419 1:STN:280: DyaK1MzmsV2hug%3D%3D 10433934 (Pubitemid 29370391)
27. EY Rhew WG Barr 2004 Scleroderma renal crisis: new insights and developments Curr Rheumatol Rep 6 129 136 15016343
28. O Distler JH Distler A Scheid, et al. 2004 Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis Circ Res 95 109 116 1:CAS:528:DC%2BD2cXlt1Cru7Y%3D 15178641 (Pubitemid 38931842)
29. AE Koch O Distler 2007 Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis Arthritis Res Ther 9 Suppl 2 S3 17767741
30. U Müller-Ladner O Distler L Ibba-Manneschi E Neumann S Gay 2009 Mechanisms of vascular damage in systemic sclerosis Autoimmunity 42 1 9
31. N Del Papa N Quirici D Soligo, et al. 2006 Bone marrow endothelial progenitors are defective in systemic sclerosis Arthritis Rheum 54 2605 2615 16868984 (Pubitemid 44205023)
32. M Kuwana Y Okazaki H Yasuoka Y Kawakami Y Ikeda 2004 Defective vasculogenesis in systemic sclerosis Lancet 364 603 610 1:CAS:528: DC%2BD2cXmslaltrY%3D 15313361 (Pubitemid 39094178)
33. J Avouac F Juin J Wipff, et al. 2008 Circulating endothelial progenitor cells in systemic sclerosis: association with disease severity Ann Rheum Dis 67 1455 1460 1:STN:280:DC%2BD1crpvFOmsA%3D%3D 18174219
34. JH Distler Y Allanore J Avouac, et al. 2009 EULAR Scleroderma Trials and Research group statement and recommendations on endothelial precursor cells Ann Rheum Dis 68 163 168 1:STN:280:DC%2BD1M%2FmsV2mug%3D%3D 18653485
35. P Cipriani S Guiducci I Miniati, et al. 2007 Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis Arthritis Rheum 56 1994 2004 1:CAS:528:DC%2BD2sXnsVOhu7k%3D 17530639 (Pubitemid 47110398)
36. S D'Alessio G Fibbi M Cinelli, et al. 2004 Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis Arthritis Rheum 50 3275 3285 15476218 (Pubitemid 39372005)
37. C Suri PF Jones S Patan, et al. 1996 Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis Cell 87 1171 1180 1:CAS:528:DyaK2sXit1GhtQ%3D%3D 8980224 (Pubitemid 27010101)
38. L Eklund BR Olsen 2006 Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling Exp Cell Res 312 630 641 1:CAS:528:DC%2BD28XhvVWlur8%3D 16225862 (Pubitemid 43290339)
39. M Hebbar JP Peyrat L Hornez PY Hatron E Hachulla B Devulder 2000 Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis Arthritis Rheum 43 889 893 1:CAS:528:DC%2BD3cXivFOit7w%3D 10765935
40. O Distler A Del Rosso R Giacomelli, et al. 2002 Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers Arthritis Res 4 R11 12453314
41. S Yamagishi T Imaizumi 2005 Pericyte biology and diseases Int J Tissue React 27 125 135 1:CAS:528:DC%2BD28XpsF2gtg%3D%3D 16372479 (Pubitemid 41723729)
42. P Helmbold E Fiedler M Fischer W Marsch 2004 Hyperplasia of dermal microvascular pericytes in scleroderma J Cutan Pathol 31 431 440 15186431 (Pubitemid 38845134)
43. VS Rajkumar C Sundberg DJ Abraham K Rubin CM Black 1999 Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis Arthritis Rheum 42 930 941 1:CAS:528:DyaK1MXjtlKjur0%3D 10323448 (Pubitemid 29215003)
44. VS Rajkumar K Howell K Csiszar CP Denton CM Black DJ Abraham 2005 Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis Arthritis Res Ther 7 R1113 R1123 1:CAS:528:DC%2BD2MXpvFOgurg%3D 16207328
45. SL Lin T Kisseleva DA Brenner JS Duffield 2008 Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney Am J Pathol 173 1617 1627 1:CAS:528: DC%2BD1MXkt1CktQ%3D%3D 19008372
46. DJ Abraham J Varga 2005 Scleroderma: from cell and molecular mechanisms to disease models Trends Immunol 26 587 595 1:CAS:528:DC%2BD2MXhtFeiu7rJ 16168711 (Pubitemid 41726446)
47. ML Whitfield DR Finlay JI Murray, et al. 2003 Systemic and cell type-specific gene expression patterns in scleroderma skin Proc Natl Acad Sci USA 100 12319 12324 1:CAS:528:DC%2BD3sXotlGksL8%3D 14530402 (Pubitemid 37271558)
48. S Sato M Hasegawa M Fujimoto TF Tedder K Takehara 2000 Quantitative genetic variation in CD19 expression correlates with autoimmunity J Immunol 165 6635 6643 1:CAS:528:DC%2BD3cXosFOhtro%3D 11086109
49. S Sato M Fujimoto M Hasegawa K Takehara 2004 Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells Arthritis Rheum 50 1918 1927 15188368 (Pubitemid 38725103)
50. M Hasegawa Y Hamaguchi K Yanaba, et al. 2006 B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis Am J Pathol 169 954 966 1:CAS:528:DC%2BD28XpvFWqsrg%3D 16936269 (Pubitemid 44411958)
51. ML Harris A Rosen 2003 Autoimmunity in scleroderma: the origin, pathogenetic role, and clinical significance of autoantibodies Curr Opin Rheumatol 15 778 784 1:CAS:528:DC%2BD3sXot12htLs%3D 14569210 (Pubitemid 38156307)
52. J Rosenbaum BE Pottinger P Woo, et al. 1988 Measurement and characterisation of circulating anti-endothelial cell IgG in connective tissue diseases Clin Exp Immunol 72 450 456 1:STN:280:DyaL1M%2FgtlOhtg%3D%3D 3168322
53. D Carvalho CO Savage CM Black JD Pearson 1996 IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines J Clin Invest 97 111 119 1:CAS:528:DyaK28Xhtlaju78%3D 8550821
54. SS Baroni M Santillo F Bevilacqua, et al. 2006 Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis N Engl J Med 354 2667 2676 1:CAS:528:DC%2BD28XmtFSgtLg%3D 16790699
55. M Hasegawa M Fujimoto K Takehara S Sato 2005 Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis J Dermatol Sci 39 1 7 1:CAS:528:DC%2BD2MXlsFCrtr8%3D 15885984 (Pubitemid 40835827)
56. GH Stummvoll M Aringer J Grisar, et al. 2004 Increased transendothelial migration of scleroderma lymphocytes Ann Rheum Dis 63 569 574 1:STN:280:DC%2BD2c7osFSisw%3D%3D 15082489 (Pubitemid 38530202)
57. LI Sakkas B Xu CM Artlett S Lu SA Jimenez CD Platsoucas 2002 Oligoclonal T cell expansion in the skin of patients with systemic sclerosis J Immunol 168 3649 3659 1:CAS:528:DC%2BD38Xis1ajur0%3D 11907131 (Pubitemid 34250437)
58. CM Artlett 2005 Immunology of systemic sclerosis Front Biosci 10 1707 1719 1:CAS:528:DC%2BD2MXisVers78%3D 15769660 (Pubitemid 40529032)
59. VD Steen EE Engel MR Charley TA Medsger Jr 1996 Soluble serum interleukin 2 receptors in patients with systemic sclerosis J Rheumatol 23 646 649 1:STN:280:DyaK283otVWlsA%3D%3D 8730120 (Pubitemid 26132849)
60. LE French SR Lessin K Addya, et al. 2001 Identification of clonal T cells in the blood of patients with systemic sclerosis: positive correlation with response to photopheresis Arch Dermatol 137 1309 1313 1:STN:280: DC%2BD3MrntVansQ%3D%3D 11594854 (Pubitemid 32954180)
61. TA Wynn 2004 Fibrotic disease and the T(H)1/T(H)2 paradigm Nat Rev Immunol 4 583 594 1:CAS:528:DC%2BD2cXmtFWktr0%3D 15286725
62. A Wangoo T Sparer IN Brown, et al. 2001 Contribution of Th1 and Th2 cells to protection and pathology in experimental models of granulomatous lung disease J Immunol 166 3432 3439 1:CAS:528:DC%2BD3MXhs1Ois70%3D 11207301 (Pubitemid 33117346)
63. G Lakos D Melichian M Wu J Varga 2006 Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet Pathobiology 73 224 237 1:CAS:528:DC%2BD2sXjsVOqtbc%3D 17314493 (Pubitemid 46332830)
64. FK Tan X Zhou MD Mayes, et al. 2006 Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients Rheumatology (Oxford) 45 694 702 1:CAS:528:DC%2BD28Xmt1Wkurc%3D (Pubitemid 43985337)
65. C Mavalia C Scaletti P Romagnani, et al. 1997 Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis Am J Pathol 151 1751 1758 1:STN:280:DyaK1c%2FmsF2rsQ%3D%3D 9403725 (Pubitemid 27527937)
66. SP Atamas VV Yurovsky R Wise, et al. 1999 Production of type 2 cytokines by CD8+ lung cells is associated with greater decline in pulmonary function in patients with systemic sclerosis Arthritis Rheum 42 1168 1178 1:CAS:528:DyaK1MXktVegtL4%3D 10366109 (Pubitemid 29268953)
67. P Rottoli B Magi MG Perari, et al. 2005 Cytokine profile and proteome analysis in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis Proteomics 5 1423 1430 1:CAS:528:DC%2BD2MXjtlSjurg%3D 15761959
68. C Chizzolini Y Parel C De Luca, et al. 2003 Systemic sclerosis Th2 cells inhibit collagen production by dermal fibroblasts via membrane-associated tumor necrosis factor alpha Arthritis Rheum 48 2593 2604 1:CAS:528: DC%2BD3sXot1Wjt7w%3D 13130479 (Pubitemid 37129436)
69. T Matsushita M Hasegawa Y Hamaguchi K Takehara S Sato 2006 Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis J Rheumatol 33 275 284 1:CAS:528:DC%2BD28XhvFOnt78%3D 16465658 (Pubitemid 43209303)
70. R Giacomelli P Cipriani A Fulminis, et al. 2001 Circulating gamma/delta T lymphocytes from systemic sclerosis (SSc) patients display a T helper (Th) 1 polarization Clin Exp Immunol 125 310 315 1:CAS:528:DC%2BD3MXmslyns7c%3D 11529924 (Pubitemid 32758443)
71. R Giacomelli M Matucci-Cerinic P Cipriani, et al. 1998 Circulating Vdelta1+ T cells are activated and accumulate in the skin of systemic sclerosis patients Arthritis Rheum 41 327 334 1:STN:280:DyaK1c7ktlKhtw%3D%3D 9485091 (Pubitemid 28087701)
72. HY Chang JT Chi S Dudoit, et al. 2002 Diversity, topographic differentiation, and positional memory in human fibroblasts Proc Natl Acad Sci USA 99 12877 12882 1:CAS:528:DC%2BD38XnvFGhtr0%3D 12297622
73. DJ Abraham B Eckes V Rajkumar T Krieg 2007 New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma Curr Rheumatol Rep 9 136 143 1:CAS:528:DC%2BD2sXhtVehsr3M 17502044 (Pubitemid 46932720)
74. A Desmouliere C Chaponnier G Gabbiani 2005 Tissue repair, contraction, and the myofibroblast Wound Repair Regen 13 7 12 15659031 (Pubitemid 40250424)
75. R Kalluri EG Neilson 2003 Epithelial-mesenchymal transition and its implications for fibrosis J Clin Invest 112 1776 1784 1:CAS:528: DC%2BD3sXhtVSmtLrL 14679171 (Pubitemid 38063698)
76. M Zeisberg J Hanai H Sugimoto, et al. 2003 BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury Nat Med 9 964 968 1:CAS:528:DC%2BD3sXkvFOjs7Y%3D 12808448 (Pubitemid 36889942)
77. R Abe SC Donnelly T Peng R Bucala CN Metz 2001 Peripheral blood fibrocytes: differentiation pathway and migration to wound sites J Immunol 166 7556 7562 1:CAS:528:DC%2BD3MXksVOmsL8%3D 11390511 (Pubitemid 32525636)
78. P Cipriani A Franca Milia V Liakouli, et al. 2006 Differential expression of stromal cell-derived factor 1 and its receptor CXCR4 in the skin and endothelial cells of systemic sclerosis patients: pathogenetic implications Arthritis Rheum 54 3022 3033 1:CAS:528:DC%2BD28XhtFWksLbI 16948134 (Pubitemid 44497784)
79. RJ Phillips MD Burdick K Hong, et al. 2004 Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis J Clin Invest 114 438 446 1:CAS:528:DC%2BD2cXmtlyns7s%3D 15286810 (Pubitemid 39071616)
80. M Kuwana Y Okazaki H Kodama, et al. 2003 Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation J Leukoc Biol 74 833 845 1:CAS:528:DC%2BD3sXpt1CrtLs%3D 12960274 (Pubitemid 38040360)
81. J Pannu M Trojanowska 2004 Recent advances in fibroblast signaling and biology in scleroderma Curr Opin Rheumatol 16 739 745 1:CAS:528: DC%2BD2cXhtVaht7jO 15577613 (Pubitemid 39425548)
82. J Massague RR Gomis 2006 The logic of TGFbeta signaling FEBS Lett 580 2811 2820 1:CAS:528:DC%2BD28XltVKntrg%3D 16678165
83. J Varga RI Bashey 1995 Regulation of connective tissue synthesis in systemic sclerosis Int Rev Immunol 12 187 199 1:STN:280:DyaK2MznvVOhsA%3D%3D 7650421
84. GC Blobe WP Schiemann HF Lodish 2000 Role of transforming growth factor beta in human disease N Engl J Med 342 1350 1358 1:CAS:528:DC%2BD3cXjtlyksrY%3D 10793168 (Pubitemid 30408720)
85. A Moustakas CH Heldin 2005 Non-Smad TGF-beta signals J Cell Sci 118 3573 3584 1:CAS:528:DC%2BD2MXhtVaktrvK 16105881
86. CE Daniels MC Wilkes M Edens, et al. 2004 Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis J Clin Invest 114 1308 1316 1:CAS:528:DC%2BD2cXpsFCgtrg%3D 15520863 (Pubitemid 40385302)
87. SJ Chen H Ning W Ishida, et al. 2006 The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression J Biol Chem 281 21183 21197 1:CAS:528:DC%2BD28Xnt1Gqu7k%3D 16702209 (Pubitemid 44115458)
88. A Igarashi K Nashiro K Kikuchi, et al. 1996 Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders J Invest Dermatol 106 729 733 1:STN:280:DyaK287otlGmtA%3D%3D 8618012 (Pubitemid 26119731)
89. A Leask 2009 Signaling in fibrosis: targeting the TGF beta, endothelin-1 and CCN2 axis in scleroderma Front Biosci (Elite Ed) 1 115 122
90. S Gay RE Jones Jr GQ Huang RE Gay 1989 Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma J Invest Dermatol 92 301 303 1:STN:280:DyaL1M7ktVCjsw%3D%3D 2918236 (Pubitemid 19061278)
91. A Ludwicka T Ohba M Trojanowska, et al. 1995 Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma J Rheumatol 22 1876 1883 1:CAS:528:DyaK2MXpsVWjsbY%3D 8991985
92. M Jinnin H Ihn K Yamane K Tamaki 2004 Interleukin-13 stimulates the transcription of the human alpha2(I) collagen gene in human dermal fibroblasts J Biol Chem 279 41783 41791 1:CAS:528:DC%2BD2cXnvFWgtbw%3D 15271999 (Pubitemid 39313625)
93. M Kaviratne M Hesse M Leusink, et al. 2004 IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent J Immunol 173 4020 4029 1:CAS:528:DC%2BD2cXnsVWktL4%3D 15356151 (Pubitemid 39280766)
94. AE Postlethwaite MA Holness H Katai R Raghow 1992 Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4 J Clin Invest 90 1479 1485 1:CAS:528:DyaK3sXltl2n 1401080
95. V Salmon-Ehr H Serpier B Nawrocki, et al. 1996 Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis Arch Dermatol 132 802 806 1:STN:280: DyaK283otVKjtw%3D%3D 8678573 (Pubitemid 26238869)
96. M Hasegawa M Fujimoto K Kikuchi K Takehara 1997 Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis J Rheumatol 24 328 332 1:STN:280:DyaK2s7oslGguw%3D%3D 9034992 (Pubitemid 27104098)
97. J Tsuji-Yamada M Nakazawa M Minami T Sasaki 2001 Increased frequency of interleukin 4 producing CD4+ and CD8+ cells in peripheral blood from patients with systemic sclerosis J Rheumatol 28 1252 1258 1:STN:280: DC%2BD38%2Fht1eitw%3D%3D 11409116 (Pubitemid 32510495)
98. JH Distler A Jungel D Caretto, et al. 2006 Monocyte chemoattractant protein 1 released from glycosaminoglycans mediates its profibrotic effects in systemic sclerosis via the release of interleukin-4 from T cells Arthritis Rheum 54 214 225 1:CAS:528:DC%2BD28XhsVensLg%3D 16385517 (Pubitemid 43122204)
99. M Kodera M Hasegawa K Komura K Yanaba K Takehara S Sato 2005 Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis Arthritis Rheum 52 2889 2896 1:CAS:528:DC%2BD2MXhtFeltrnL 16142750 (Pubitemid 41369120)
100. SA Jimenez B Freundlich J Rosenbloom 1984 Selective inhibition of human diploid fibroblast collagen synthesis by interferons J Clin Invest 74 1112 1116 1:CAS:528:DyaL2cXls1ykurY%3D 6432846 (Pubitemid 14031053)
101. AK Ghosh W Yuan Y Mori S Chen J Varga 2001 Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators J Biol Chem 276 11041 11048 1:CAS:528:DC%2BD3MXjvFGjsro%3D 11134049 (Pubitemid 38089285)
102. T Arai K Abe H Matsuoka, et al. 2000 Introduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo Am J Physiol Lung Cell Mol Physiol 278 L914 L922 1:CAS:528:DC%2BD3cXjvFagtLo%3D 10781421
103. V Barbarin Z Xing M Delos D Lison F Huaux 2005 Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles Am J Physiol Lung Cell Mol Physiol 288 L841 L848 1:CAS:528:DC%2BD2MXktlSnt70%3D 15608148
104. SJ Chen W Yuan Y Mori A Levenson M Trojanowska J Varga 1999 Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3 J Invest Dermatol 112 49 57 1:CAS:528:DyaK1MXjvFWitA%3D%3D 9886263 (Pubitemid 29024705)
105. SJ Chen CM Artlett SA Jimenez J Varga 1998 Modulation of human alpha1(I) procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitro Gene 215 101 110 1:CAS:528:DyaK1cXltlKmtrc%3D 9666093 (Pubitemid 28359223)
106. J Czuwara-Ladykowska VI Sementchenko DK Watson M Trojanowska 2002 Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta J Biol Chem 277 20399 20408 1:CAS:528:DC%2BD38XkslWgt7s%3D 11919190 (Pubitemid 34967335)
107. J Czuwara-Ladykowska F Shirasaki P Jackers DK Watson M Trojanowska 2001 Fli-1 inhibits collagen type I production in dermal fibroblasts via an Sp1-dependent pathway J Biol Chem 276 20839 20848 1:CAS:528:DC%2BD3MXksFGlsrk%3D 11278621
108. AK Ghosh S Bhattacharyya J Varga 2004 The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells J Biol Chem 279 47455 47463 1:CAS:528:DC%2BD2cXptl2gtLo%3D 15345715 (Pubitemid 39540888)
109. AK Ghosh S Bhattacharyya G Lakos SJ Chen Y Mori J Varga 2004 Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma Arthritis Rheum 50 1305 1318 1:CAS:528:DC%2BD2cXjslGqsLw%3D 15077315 (Pubitemid 38480842)