Dietary therapy to promote neuroprotection in chronic spinal cord injury: Laboratory investigation

Journal of Neurosurgery: Spine

Volumn 17, Issue 2, 2012, Pages 134-140

  Holly, Langston T ^a   Blaskiewicz, Donald ^a   Wu, Aiguo ^b   Feng, Cameron ^b   Ying, Zhe ^b   Gomez Pinilla, Fernando ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Curcumin; Docosahexaenoic acid; Membrane; Myelopathy; Rat; Spinal cord injury

Indexed keywords

4 HYDROXYNONENAL; BRAIN DERIVED NEUROTROPHIC FACTOR; CURCUMIN; DOCOSAHEXAENOIC ACID; POLYMER; SYNTAXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE; CERVICAL SPONDYLOSIS; CHRONIC DISEASE; COMPUTER PROGRAM; CONTROLLED STUDY; DIET THERAPY; EPIDURAL SPACE; FUNCTIONAL ASSESSMENT; GAIT; LIPID PEROXIDATION; MAGNET; MALE; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; RAT; SPINAL CORD DISEASE; SPINAL CORD INJURY; THORACIC SPINE; TREATMENT OUTCOME; WESTERN BLOTTING;

ALDEHYDES; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHRONIC DISEASE; CURCUMA; DIET; DISEASE MODELS, ANIMAL; DOCOSAHEXAENOIC ACIDS; MALE; NEUROPROTECTIVE AGENTS; QA-SNARE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES;

EID: 84864565248     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2012.5.SPINE1216     Document Type: Article

References (27)

1. Calderon F, Kim HY: Docosahexaenoic acid promotes neurite growth in hippocampal neurons. J Neurochem 90:979-988, 2004 (Pubitemid 39099980)
2. Darios F, Davletov B: Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3. Nature 440:813-817, 2006
3. Gómez-Pinilla F: Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci 9:568-578, 2008
4. Hamaguchi T, Ono K, Yamada M: REVIEW: Curcumin and Alzheimer's disease. CNS Neurosci Ther 16:285-297, 2010
5. Henderson FC, Geddes JF, Vaccaro AR, Woodard E, Berry KJ, Benzel EC: Stretch-associated injury in cervical spondylotic myelopathy: new concept and review. Neurosurgery 56: 1101-1113, 2005
6. Horrocks LA, Farooqui AA: Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. Prostaglandins Leukot Essent Fatty Acids 70:361-372, 2004 (Pubitemid 38429269)
7. Huang WL, King VR, Curran OE, Dyall SC, Ward RE, Lal N, et al: A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. Brain 130:3004-3019, 2007 (Pubitemid 350033967)
8. Jyoti A, Sethi P, Sharma D: Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis. Epilepsy Behav 14: 300-308, 2009
9. Kanoski SE, Davidson TL: Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol Behav 103:59-68, 2011
10. Kasahara K, Nakagawa T, Kubota T: Neuronal loss and expression of neurotrophic factors in a model of rat chronic compressive spinal cord injury. Spine (Phila Pa 1976) 31: 2059-2066, 2006
11. Kim DH, Vaccaro AR, Henderson FC, Benzel EC: Molecular biology of cervical myelopathy and spinal cord injury: role of oligodendrocyte apoptosis. Spine J 3:510-519, 2003 (Pubitemid 37337239)
12. Kim P, Haisa T, Kawamoto T, Kirino T, Wakai S: Delayed myelopathy induced by chronic compression in the rat spinal cord. Ann Neurol 55:503-511, 2004 (Pubitemid 38391967)
13. Koda M, Murakami M, Ino H, Yoshinaga K, Ikeda O, Hashimoto M, et al: Brain-derived neurotrophic factor suppresses delayed apoptosis of oligodendrocytes after spinal cord injury in rats. J Neurotrauma 19:777-785, 2002 (Pubitemid 34761339)
14. Lapchak PA: Neuroprotective and neurotrophic curcuminoids to treat stroke: a translational perspective. Expert Opin Investig Drugs 20:13-22, 2011
15. Maier IC, Schwab ME: Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity. Philos Trans R Soc Lond B Biol Sci 361:1611-1634, 2006 (Pubitemid 44450214)
16. McMahon HT, Südhof TC: Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site. J Biol Chem 270:2213-2217, 1995
17. Merenda A, Gugliotta M, Holloway R, Levasseur JE, Alessandri B, Sun D, et al: Validation of brain extracellular glycerol as an indicator of cellular membrane damage due to free radical activity after traumatic brain injury. J Neurotrauma 25: 527-537, 2008 (Pubitemid 351685484)
18. Salem N Jr, Litman B, Kim HY, Gawrisch K: Mechanisms of action of docosahexaenoic acid in the nervous system. Lipids 36:945-959, 2001 (Pubitemid 33065196)
19. Sharma S, Ying Z, Gomez-Pinilla F: A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma. Exp Neurol 226:191-199, 2010
20. Sharma S, Zhuang Y, Ying Z, Wu A, Gomez-Pinilla F: Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. Neuroscience 161:1037-1044, 2009
21. Stillwell W, Shaikh SR, Zerouga M, Siddiqui R, Wassall SR: Docosahexaenoic acid affects cell signaling by altering lipid rafts. Reprod Nutr Dev 45:559-579, 2005 (Pubitemid 41511882)
22. Wakade C, King MD, Laird MD, Alleyne CH Jr, Dhandapani KM: Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice. Antioxid Redox Signal 11:35-45, 2009
23. Wu A, Ying Z, Gomez-Pinilla F: Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol 197:309-317, 2006 (Pubitemid 43077138)
24. Wu A, Ying Z, Gomez-Pinilla F: Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience 155:751-759, 2008
25. Wu A, Ying Z, Schubert D, Gomez-Pinilla F: Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma. Neurorehabil Neural Repair 25:332-342, 2011
26. Xu K, Uchida K, Nakajima H, Kobayashi S, Baba H: Targeted retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene prevents loss of mouse (twy/ twy) anterior horn neurons in vivo sustaining mechanical compression. Spine (Phila Pa 1976) 31:1867-1874, 2006
27. Yamaura I, Yone K, Nakahara S, Nagamine T, Baba H, Uchida K, et al: Mechanism of destructive pathologic changes in the spinal cord under chronic mechanical compression. Spine (Phila Pa 1976) 27:21-26, 2002