메뉴 건너뛰기




Volumn 7, Issue 8, 2012, Pages

Frequency of Th17 CD4+ T cells in early rheumatoid arthritis: A marker of anti-CCP seropositivity

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR6; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; METHOTREXATE; PREDNISONE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84864541677     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042189     Document Type: Article
Times cited : (42)

References (40)
  • 1
    • 77953256541 scopus 로고    scopus 로고
    • Targeting IL-17 and Th17 cells in rheumatoid arthritis
    • Sarkar S, Fox DA, (2010) Targeting IL-17 and Th17 cells in rheumatoid arthritis. Rheum Dis Clin North Am 36: 345-366.
    • (2010) Rheum Dis Clin North Am , vol.36 , pp. 345-366
    • Sarkar, S.1    Fox, D.A.2
  • 2
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae S, Nambu A, Sudo K, Iwakura Y, (2003) Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 171: 6173-6177.
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 3
    • 0036188478 scopus 로고    scopus 로고
    • Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein
    • Bush KA, Farmer KM, Walker JS, Kirkham BW, (2002) Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. Arthritis Rheum 46: 802-805.
    • (2002) Arthritis Rheum , vol.46 , pp. 802-805
    • Bush, K.A.1    Farmer, K.M.2    Walker, J.S.3    Kirkham, B.W.4
  • 4
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    • Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, et al. (2004) Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 50: 650-659.
    • (2004) Arthritis Rheum , vol.50 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3    van den Bersselaar, L.4    Coenen-de Roo, C.J.5
  • 5
    • 0037371262 scopus 로고    scopus 로고
    • IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance
    • Lubberts E, van den Bersselaar L, Oppers-Walgreen B, Schwarzenberger P, Coenen-de Roo CJ, et al. (2003) IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance. J Immunol 170: 2655-2662.
    • (2003) J Immunol , vol.170 , pp. 2655-2662
    • Lubberts, E.1    van den Bersselaar, L.2    Oppers-Walgreen, B.3    Schwarzenberger, P.4    Coenen-de Roo, C.J.5
  • 6
    • 66149105578 scopus 로고    scopus 로고
    • Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor alpha-independent mouse model
    • Plater-Zyberk C, Joosten LA, Helsen MM, Koenders MI, Baeuerle PA, et al. (2009) Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor alpha-independent mouse model. Ann Rheum Dis 68: 721-728.
    • (2009) Ann Rheum Dis , vol.68 , pp. 721-728
    • Plater-Zyberk, C.1    Joosten, L.A.2    Helsen, M.M.3    Koenders, M.I.4    Baeuerle, P.A.5
  • 7
    • 79958154418 scopus 로고    scopus 로고
    • Experimental arthritis: Therapeutic promise of dual blockade of IL-17 and TNF in inflammatory arthritis
    • Buckland J, (2011) Experimental arthritis: Therapeutic promise of dual blockade of IL-17 and TNF in inflammatory arthritis. Nat Rev Rheumatol 7: 311.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 311
    • Buckland, J.1
  • 8
    • 0032939156 scopus 로고    scopus 로고
    • Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium
    • Chabaud M, Durand JM, Buchs N, Fossiez F, Page G, et al. (1999) Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 42: 963-970.
    • (1999) Arthritis Rheum , vol.42 , pp. 963-970
    • Chabaud, M.1    Durand, J.M.2    Buchs, N.3    Fossiez, F.4    Page, G.5
  • 9
    • 0034161692 scopus 로고    scopus 로고
    • High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism
    • Ziolkowska M, Koc A, Luszczykiewicz G, Ksiezopolska-Pietrzak K, Klimczak E, et al. (2000) High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol 164: 2832-2838.
    • (2000) J Immunol , vol.164 , pp. 2832-2838
    • Ziolkowska, M.1    Koc, A.2    Luszczykiewicz, G.3    Ksiezopolska-Pietrzak, K.4    Klimczak, E.5
  • 10
    • 65549165389 scopus 로고    scopus 로고
    • In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses
    • Evans HG, Gullick NJ, Kelly S, Pitzalis C, Lord GM, et al. (2009) In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses. Proc Natl Acad Sci USA 106: 6232-6237.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 6232-6237
    • Evans, H.G.1    Gullick, N.J.2    Kelly, S.3    Pitzalis, C.4    Lord, G.M.5
  • 11
    • 70450189514 scopus 로고    scopus 로고
    • Monocyte Derived Interleukin (IL)-23 Is an Important Determinant of Synovial IL-17A Expression in Rheumatoid Arthritis
    • Stamp LK, Easson A, Petterson L, Highton J, Hessian PA, (2009) Monocyte Derived Interleukin (IL)-23 Is an Important Determinant of Synovial IL-17A Expression in Rheumatoid Arthritis. J Rheumatol 36: 2403-2408.
    • (2009) J Rheumatol , vol.36 , pp. 2403-2408
    • Stamp, L.K.1    Easson, A.2    Petterson, L.3    Highton, J.4    Hessian, P.A.5
  • 12
    • 47249125726 scopus 로고    scopus 로고
    • Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
    • Pène J, Chevalier S, Preisser L, Vénéreau E, Guilleux MH, et al. (2008) Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol 180: 7423-7430.
    • (2008) J Immunol , vol.180 , pp. 7423-7430
    • Pène, J.1    Chevalier, S.2    Preisser, L.3    Vénéreau, E.4    Guilleux, M.H.5
  • 13
    • 77950535421 scopus 로고    scopus 로고
    • LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study
    • Genovese MC, Van den Bosch F, Roberson SA, Bojin S, Biagini IM, et al. (2010) LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum 62: 929-939.
    • (2010) Arthritis Rheum , vol.62 , pp. 929-939
    • Genovese, M.C.1    van den Bosch, F.2    Roberson, S.A.3    Bojin, S.4    Biagini, I.M.5
  • 14
    • 79951846831 scopus 로고    scopus 로고
    • Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans
    • Pöllinger B, Junt T, Metzler B, Walker UA, Tyndall A, et al. (2011) Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans. J Immunol 18: 2602-2612.
    • (2011) J Immunol , vol.18 , pp. 2602-2612
    • Pöllinger, B.1    Junt, T.2    Metzler, B.3    Walker, U.A.4    Tyndall, A.5
  • 15
    • 68049097199 scopus 로고    scopus 로고
    • Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis
    • Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, et al. (2009) Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis. Arthritis Rheum 60: 2294-2303.
    • (2009) Arthritis Rheum , vol.60 , pp. 2294-2303
    • Ito, Y.1    Usui, T.2    Kobayashi, S.3    Iguchi-Hashimoto, M.4    Ito, H.5
  • 16
    • 77951636478 scopus 로고    scopus 로고
    • Mast cells express IL-17A in rheumatoid arthritis synovium
    • Hueber AJ, Asquith DL, Miller AM, Reilly J, Kerr S, et al. (2010) Mast cells express IL-17A in rheumatoid arthritis synovium. J Immunol 184: 3336-3340.
    • (2010) J Immunol , vol.184 , pp. 3336-3340
    • Hueber, A.J.1    Asquith, D.L.2    Miller, A.M.3    Reilly, J.4    Kerr, S.5
  • 17
    • 80053172579 scopus 로고    scopus 로고
    • Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium
    • Suurmond J, Dorjée AL, Boon MR, Knol EF, Huizinga TW, et al. (2011) Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and-negative rheumatoid arthritis and osteoarthritis synovium. Arthritis Res Ther 13: R150.
    • (2011) Arthritis Res Ther , vol.13
    • Suurmond, J.1    Dorjée, A.L.2    Boon, M.R.3    Knol, E.F.4    Huizinga, T.W.5
  • 18
    • 78549271154 scopus 로고    scopus 로고
    • Increased IL-17 production by peripheral T helper cells after tumour necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression
    • Aerts NE, De Knop KJ, Leysen J, Ebo DG, Bridts CH, et al. (2010) Increased IL-17 production by peripheral T helper cells after tumour necrosis factor blockade in rheumatoid arthritis is accompanied by inhibition of migration-associated chemokine receptor expression. Rheumatology (Oxford) 49: 2264-2272.
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 2264-2272
    • Aerts, N.E.1    de Knop, K.J.2    Leysen, J.3    Ebo, D.G.4    Bridts, C.H.5
  • 21
    • 84857712400 scopus 로고    scopus 로고
    • The CD14(bright) CD16+ monocyte subset is expanded in rheumatoid arthritis and promotes Th17 expansion
    • Rossol M, Kraus S, Pierer M, Baerwald C, Wagner U, (2012) The CD14(bright) CD16+ monocyte subset is expanded in rheumatoid arthritis and promotes Th17 expansion. Arthritis Rheum 64: 671-677.
    • (2012) Arthritis Rheum , vol.64 , pp. 671-677
    • Rossol, M.1    Kraus, S.2    Pierer, M.3    Baerwald, C.4    Wagner, U.5
  • 22
    • 50249164315 scopus 로고    scopus 로고
    • Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis
    • Yamada H, Nakashima Y, Okazaki K, Mawatari T, Fukushi JI, et al. (2008) Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis. Ann Rheum Dis 67: 1299-12304.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1299-12304
    • Yamada, H.1    Nakashima, Y.2    Okazaki, K.3    Mawatari, T.4    Fukushi, J.I.5
  • 23
    • 40549138745 scopus 로고    scopus 로고
    • Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers
    • Nistala K, Moncrieffe H, Newton KR, Varsani H, Hunter P, et al. (2008) Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum 58: 875-887.
    • (2008) Arthritis Rheum , vol.58 , pp. 875-887
    • Nistala, K.1    Moncrieffe, H.2    Newton, K.R.3    Varsani, H.4    Hunter, P.5
  • 24
    • 77958558441 scopus 로고    scopus 로고
    • Linking power Doppler ultrasound to the presence of Th17 cells in the rheumatoid arthritis joint
    • Gullick NJ, Evans HG, Church LD, Jayaraj DM, Filer A, et al. (2010) Linking power Doppler ultrasound to the presence of Th17 cells in the rheumatoid arthritis joint. PLoS One 5 (9).: pii: e12516.
    • (2010) PLoS One , vol.5 , Issue.9
    • Gullick, N.J.1    Evans, H.G.2    Church, L.D.3    Jayaraj, D.M.4    Filer, A.5
  • 25
    • 78650764391 scopus 로고    scopus 로고
    • Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
    • van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, et al. (2011) Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheum 63: 73-83.
    • (2011) Arthritis Rheum , vol.63 , pp. 73-83
    • van Hamburg, J.P.1    Asmawidjaja, P.S.2    Davelaar, N.3    Mus, A.M.4    Colin, E.M.5
  • 26
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31: 315-324.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5
  • 27
    • 0028815803 scopus 로고
    • Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
    • Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, et al. (1995) Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38: 44-48.
    • (1995) Arthritis Rheum , vol.38 , pp. 44-48
    • Prevoo, M.L.1    van 't Hof, M.A.2    Kuper, H.H.3    van Leeuwen, M.A.4    van de Putte, L.B.5
  • 28
    • 0346093860 scopus 로고    scopus 로고
    • Value of Disease Activity Score 28 (DAS28) and DAS28-3 compared to American College of Rheumatology-defined remission in rheumatoid arthritis
    • Balsa A, Carmona L, González-Alvaro I, Belmonte MA, Tena X, et al. (2004) Value of Disease Activity Score 28 (DAS28) and DAS28-3 compared to American College of Rheumatology-defined remission in rheumatoid arthritis. J Rheumatol 31: 40-46.
    • (2004) J Rheumatol , vol.31 , pp. 40-46
    • Balsa, A.1    Carmona, L.2    González-Alvaro, I.3    Belmonte, M.A.4    Tena, X.5
  • 29
    • 66449133523 scopus 로고    scopus 로고
    • Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis
    • Shen H, Goodall JC, Hill Gaston JS, (2009) Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum 60: 1647-1656.
    • (2009) Arthritis Rheum , vol.60 , pp. 1647-1656
    • Shen, H.1    Goodall, J.C.2    Hill Gaston, J.S.3
  • 30
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F, (2007) Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8: 942-949.
    • (2007) Nat Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 31
    • 75749090835 scopus 로고    scopus 로고
    • Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study
    • Syversen SW, Goll GL, van der Heijde D, Landewé R, Lie BA, et al. (2010) Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study. Ann Rheum Dis 69: 345-351.
    • (2010) Ann Rheum Dis , vol.69 , pp. 345-351
    • Syversen, S.W.1    Goll, G.L.2    van der Heijde, D.3    Landewé, R.4    Lie, B.A.5
  • 32
    • 79951677394 scopus 로고    scopus 로고
    • Fate mapping of IL-17-producing T cells in inflammatory responses
    • Hirota K, Duarte JH, Veldhoen M, Hornsby E, Li Y, et al. (2011) Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol 12: 255-263.
    • (2011) Nat Immunol , vol.12 , pp. 255-263
    • Hirota, K.1    Duarte, J.H.2    Veldhoen, M.3    Hornsby, E.4    Li, Y.5
  • 33
    • 0030970556 scopus 로고    scopus 로고
    • The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives
    • Fox DA, (1997) The role of T cells in the immunopathogenesis of rheumatoid arthritis: new perspectives. Arthritis Rheum 40: 598-609.
    • (1997) Arthritis Rheum , vol.40 , pp. 598-609
    • Fox, D.A.1
  • 34
    • 0035109181 scopus 로고    scopus 로고
    • Rheumatoid synovial CD4+ T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells
    • Davis LS, Cush JJ, Schulze-Koops H, Lipsky PE, (2001) Rheumatoid synovial CD4+ T cells exhibit a reduced capacity to differentiate into IL-4-producing T-helper-2 effector cells. Arthritis Res 3: 54-64.
    • (2001) Arthritis Res , vol.3 , pp. 54-64
    • Davis, L.S.1    Cush, J.J.2    Schulze-Koops, H.3    Lipsky, P.E.4
  • 35
    • 0025135127 scopus 로고
    • Spontaneous and in vitro activation of synovial fluid and peripheral blood lymphocytes in rheumatoid arthritis
    • Konttinen YT, Pettersson T, Kemppinen P, Friman C, (1990) Spontaneous and in vitro activation of synovial fluid and peripheral blood lymphocytes in rheumatoid arthritis. Clin Rheumatol 9: 325-332.
    • (1990) Clin Rheumatol , vol.9 , pp. 325-332
    • Konttinen, Y.T.1    Pettersson, T.2    Kemppinen, P.3    Friman, C.4
  • 36
    • 79953648654 scopus 로고    scopus 로고
    • Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease
    • Daha NA, Toes RE, (2011) Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease? Nat Rev Rheumatol 7: 202-203.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 202-203
    • Daha, N.A.1    Toes, R.E.2
  • 37
    • 21644454004 scopus 로고    scopus 로고
    • Pathogenesis of rheumatoid arthritis: how early is early
    • Firestein GS, (2005) Pathogenesis of rheumatoid arthritis: how early is early? Arthritis Res Ther 7: 157-159.
    • (2005) Arthritis Res Ther , vol.7 , pp. 157-159
    • Firestein, G.S.1
  • 38
    • 58149166804 scopus 로고    scopus 로고
    • Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    • Notley CA, Inglis JJ, Alzabin S, McCann FE, McNamee KE, et al. (2008) Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells. J Exp Med 205: 2491-2497.
    • (2008) J Exp Med , vol.205 , pp. 2491-2497
    • Notley, C.A.1    Inglis, J.J.2    Alzabin, S.3    McCann, F.E.4    McNamee, K.E.5
  • 39
    • 84857771414 scopus 로고    scopus 로고
    • One Year Efficacy and Safety Results of a Phase II Trial of Secukinumab in Patients with Rheumatoid Arthritis. [abstract]
    • Genovese MC, Durez P, Richards HB, Supronik J, Dokoupilova E, et al. (2011) One Year Efficacy and Safety Results of a Phase II Trial of Secukinumab in Patients with Rheumatoid Arthritis. [abstract]. Arthritis Rheum 63 Suppl 10: 401.
    • (2011) Arthritis Rheum , vol.63 , pp. 401
    • Genovese, M.C.1    Durez, P.2    Richards, H.B.3    Supronik, J.4    Dokoupilova, E.5
  • 40
    • 84874552498 scopus 로고    scopus 로고
    • A Phase 2 Study of Multiple Subcutaneous Doses of LY2439821, An Anti-IL-17 Monoclonal Antibody, in Patients with Rheumatoid Arthritis in Two Populations: Naïve to Biologic Therapy or Inadequate Responders to Tumor Necrosis Factor Alpha Inhibitors. [abstract]
    • Genovese MC, Greenwald MW, Cho CS, Berman A, Jin L, et al. (2011) A Phase 2 Study of Multiple Subcutaneous Doses of LY2439821, An Anti-IL-17 Monoclonal Antibody, in Patients with Rheumatoid Arthritis in Two Populations: Naïve to Biologic Therapy or Inadequate Responders to Tumor Necrosis Factor Alpha Inhibitors. [abstract]. Arthritis Rheum 63 Suppl 10: 2591.
    • (2011) Arthritis Rheum , vol.63 , pp. 2591
    • Genovese, M.C.1    Greenwald, M.W.2    Cho, C.S.3    Berman, A.4    Jin, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.