Additional role for the ccd operon of F-plasmid as a transmissible persistence factor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 31, 2012, Pages 12497-12502

  Tripathi, Arti ^a   Dewan, Pooja C ^a   Barua, Bipasha ^a   Varadarajan, Raghavan ^a,b  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

CcdA CcdB; Conditional regulation; Protein protein interaction

Indexed keywords

ANTITOXIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ENDOPEPTIDASE LA; F FACTOR; RECA PROTEIN; TOXIN;

ANTIBIOTIC RESISTANCE; ARTICLE; CCDA GENE; CCDB GENE; CONTROLLED STUDY; GENE; GENE FUNCTION; GENE LOCUS; HEAT STRESS; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PLASMID; PRIORITY JOURNAL;

BACTERIAL PROTEINS; DNA GYRASE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; F FACTOR; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC LOCI; MUTAGENESIS, SITE-DIRECTED; OPERON; PROTEASE LA;

BACTERIA (MICROORGANISMS);

EID: 84864528505     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1121217109     Document Type: Article

References (28)

1. Hayes F (2003) Toxins-antitoxins: Plasmid maintenance, programmed cell death, and cell cycle arrest. Science 301:1496-1499.
2. Van Melderen L, Bernard P, Couturier M (1994) Lon-dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid-free segregant bacteria. Mol Microbiol 11:1151-1157. (Pubitemid 24201630)
3. Pandey DP, Gerdes K (2005) Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic Acids Res 33:966-976. (Pubitemid 41430517)
4. Van Melderen L, Saavedra De Bast M (2009) Bacterial toxin-antitoxin systems: More than selfish entities? PLoS Genet 5:e1000437.
5. Maisonneuve E, Shakespeare LJ, Jørgensen MG, Gerdes K (2011) Bacterial persistence by RNA endonucleases. Proc Natl Acad Sci USA 108:13206-13211.
6. Balaban NQ, Merrin J, Chait R, Kowalik L, Leibler S (2004) Bacterial persistence as a phenotypic switch. Science 305:1622-1625. (Pubitemid 39296357)
7. Lewis K (2010) Persister cells. Annu Rev Microbiol 64:357-372.
8. Ogura T, Hiraga S (1983) Partition mechanism of F plasmid: Two plasmid gene-encoded products and a cis-acting region are involved in partition. Cell 32:351-360.
9. Bernard P, Couturier M (1992) Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes. J Mol Biol 226:735-745.
10. Bajaj K, Chakrabarti P, Varadarajan R (2005) Mutagenesis-based definitions and probes of residue burial in proteins. Proc Natl Acad Sci USA 102:16221-16226. (Pubitemid 41688895)
11. Dao-Thi MH, et al. (2005) Molecular basis of gyrase poisoning by the addiction toxin CcdB. J Mol Biol 348:1091-1102.
12. Bajaj K, et al. (2008) Structural correlates of the temperature sensitive phenotype derived from saturation mutagenesis studies of CcdB. Biochemistry 47:12964-12973.
13. Guzman LM, Belin D, Carson MJ, Beckwith J (1995) Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol 177:4121-4130.
14. Afif H, Allali N, Couturier M, Van Melderen L (2001) The ratio between CcdA and CcdB modulates the transcriptional repression of the ccd poison-antidote system. Mol Microbiol 41:73-82. (Pubitemid 32660984)
15. Bahassi EM, Salmon MA, Van Melderen L, Bernard P, Couturier M (1995) F plasmid CcdB killer protein: CcdB gene mutants coding for non-cytotoxic proteins which retain their regulatory functions. Mol Microbiol 15:1031-1037.
16. Couturier M, Bahassi el-M, Van Melderen L (1998) Bacterial death by DNA gyrase poisoning. Trends Microbiol 6:269-275.
17. Dörr T, Vulić M, Lewis K (2010) Ciprofloxacin causes persister formation by inducing the TisB toxin in Escherichia coli. PLoS Biol 8:e1000317.
18. Lusetti SL, Cox MM (2002) The bacterial RecA protein and the recombinational DNA repair of stalled replication forks. Annu Rev Biochem 71:71-100. (Pubitemid 34800215)
19. Tsilibaris V, Maenhaut-Michel G, Van Melderen L (2006) Biological roles of the Lon ATP-dependent protease. Res Microbiol 157:701-713. (Pubitemid 44389733)
20. Aguirre-Ramírez M, Ramírez-Santos J, Van Melderen L, Gómez-Eichelmann MC (2006) Expression of the F plasmid ccd toxin-antitoxin system in Escherichia coli cells under nutritional stress. Can J Microbiol 52:24-30.
21. Kohanski MA, DePristo MA, Collins JJ (2010) Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis. Mol Cell 37:311-320.
22. De Jonge N, et al. (2009) Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain. Mol Cell 35:154-163.
23. Wilbaux M, Mine N, Guérout AM, Mazel D, Van Melderen L (2007) Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7. J Bacteriol 189:2712-2719. (Pubitemid 46556053)
24. Keren I, Shah D, Spoering A, Kaldalu N, Lewis K (2004) Specialized persister cells and the mechanism of multidrug tolerance in Escherichia coli. J Bacteriol 186:8172-8180. (Pubitemid 39603206)
25. Shah D, et al. (2006) Persisters: A distinct physiological state of E. coli. BMC Microbiol 6:53.
26. Mine N, Guglielmini J, Wilbaux M, Van Melderen L (2009) The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species. Genetics 181:1557-1566.
27. Madl T, et al. (2006) Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA. J Mol Biol 364:170-185. (Pubitemid 44647253)
28. Bajaj K, Chakshusmathi G, Bachhawat-Sikder K, Surolia A, Varadarajan R (2004) Thermodynamic characterization of monomeric and dimeric forms of CcdB (controller of cell division or death B protein). Biochem J 380:409-417. (Pubitemid 38788112)