Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 31, 2012, Pages 12562-12567

  Lie, Pearl P Y ^a   Mruk, Dolores D ^a   Mok, Ka Wai ^a   Su, Linlin ^a   Lee, Will M ^b   Cheng, C Yan ^a  

^a POPULATION COUNCIL   (United States)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Actin filament network; Ectoplasmic specialization

Indexed keywords

ACTIN RELATED PROTEIN 2-3 COMPLEX; FOCAL ADHESION KINASE; GLUTAMIC ACID; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PHENYLALANINE;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; BLOOD TESTIS BARRIER; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; HEMODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; MALE; MUTATION; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; RAT; SERTOLI CELL; SPERMATOGENESIS; TIGHT JUNCTION;

ACTINS; AMINO ACID SUBSTITUTION; ANIMALS; BLOOD-TESTIS BARRIER; CYTOSKELETON; FOCAL ADHESION KINASE 1; MALE; MEMBRANE PROTEINS; MUTATION, MISSENSE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; RATS; SERTOLI CELLS; SPERMATOCYTES; SPERMATOGENESIS; TIGHT JUNCTIONS; WISKOTT-ALDRICH SYNDROME PROTEIN;

RATTUS;

EID: 84864510712     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1202316109     Document Type: Article

References (27)

1. Cheng CY, Mruk DD (2012) The blood-testis barrier and its implications for male contraception. Pharmacol Rev 64:16-64.
2. Cheng CY, Mruk DD (2010) A local autocrine axis in the testes that regulates spermatogenesis. Nat Rev Endocrinol 6:380-395.
3. Siu MKY, Mruk DD, Lee WM, Cheng CY (2003) Adhering junction dynamics in the testis are regulated by an interplay of β 1-integrin and focal adhesion complex-associated proteins. Endocrinology 144:2141-2163. (Pubitemid 36543354)
4. Beardsley A, Robertson DM, O'Donnell L (2006) A complex containing α6β1-integrin and phosphorylated focal adhesion kinase between Sertoli cells and elongated spermatids during spermatid release from the seminiferous epithelium. J Endocrinol 190:759-770. (Pubitemid 44560251)
5. O'Donnell L, Nicholls PK, O'Bryan MK, McLachlan RI, Stanton PG (2011) Spermiation: The process of sperm release. Spermatogenesis 1:14-35.
6. Siu ER, Wong EWP, Mruk DD, Porto CS, Cheng CY (2009) Focal adhesion kinase is a blood-testis barrier regulator. Proc Natl Acad Sci USA 106:9298-9303.
7. Mitra SK, Hanson DA, Schlaepfer DD (2005) Focal adhesion kinase: In command and control of cell motility. Nat Rev Mol Cell Biol 6:56-68. (Pubitemid 40064899)
8. Tomar A, Schlaepfer DD (2009) Focal adhesion kinase: Switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol 21:676-683.
9. Schaller MD (2010) Cellular functions of FAK kinases: Insight into molecular mechanisms and novel functions. J Cell Sci 123:1007-1013.
10. Quadri SK (2012) Cross talk between focal adhesion kinase and cadherins: Role in regulating endothelial barrier function. Microvasc Res 83:3-11.
11. Goley ED, Welch MD (2006) The ARP2/3 complex: An actin nucleator comes of age. Nat Rev Mol Cell Biol 7:713-726. (Pubitemid 44450456)
12. Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL (2004) Focal adhesion kinase regulation of N-WASP subcellular localization and function. J Biol Chem 279:9565-9576. (Pubitemid 38296025)
13. Serrels B, et al. (2007) Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol 9:1046-1056. (Pubitemid 47338144)
14. Lim Y, et al. (2007) Focal adhesion kinase is negatively regulated by phosphorylation at tyrosine 407. J Biol Chem 282:10398-10404. (Pubitemid 47093453)
15. Lie PPY, Cheng CY, Mruk DD (2010) Crosstalk between desmoglein-2/ desmocollin-2/ Src kinase and coxsackie and adenovirus receptor/ZO-1 protein complexes, regulates blood-testis barrier dynamics. Int J Biochem Cell Biol 42:975-986.
16. Mruk DD, Cheng CY (2011) An in vitro system to study Sertoli cell blood-testis barrier dynamics. Methods Mol Biol 763:237-252.
17. Mitra SK, Schlaepfer DD (2006) Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18:516-523. (Pubitemid 44332916)
18. Carragher NO, Frame MC (2004) Focal adhesion and actin dynamics: A place where kinases and proteases meet to promote invasion. Trends Cell Biol 14:241-249. (Pubitemid 38591328)
19. Siesser PMF, et al. (2008) A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly. Cell Motil Cytoskeleton 65:25-39.
20. Zhai J, et al. (2003) Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem 278:24865-24873. (Pubitemid 37548645)
21. Schober M, et al. (2007) Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J Cell Biol 176:667-680. (Pubitemid 46333981)
22. Webb DJ, et al. (2004) FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol 6:154-161. (Pubitemid 38425715)
23. Ivey NS,etal. (2009) Associationof FAK activation with lentivirus-induced disruption of blood-brain barrier tight junction-associated ZO-1 protein organization. J Neurovirol 15:312-323.
24. Avizienyte E, et al. (2002) Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol 4:632-638.
25. Young JS, Guttman JA, Vaid KS, Vogl AW (2009) Tubulobulbar complexes are intercellular podosome-like structures that internalize intact intercellular junctions during epithelial remodeling events in the rat testis. Biol Reprod 80:162-174.
26. Yan HHN, Cheng CY (2006) Laminin α 3 forms a complex with β3 and γ3 chains that serves as the ligand for α6β1-integrin at the apical ectoplasmic specialization in adult rat testes. J Biol Chem 281:17286-17303.
27. Yan HHN, Mruk DD, Wong EWP, Lee WM, Cheng CY (2008) An autocrine axis in the testis that coordinates spermiation and blood-testis barrier restructuring during spermatogenesis. Proc Natl Acad Sci USA 105:8950-8955.