Therapeutic Effect of Adipose-Derived Stem Cells and BDNF-immobilized PLGA Membrane in a Rat Model of Cavernous Nerve Injury

Journal of Sexual Medicine

Volumn 9, Issue 8, 2012, Pages 1968-1979

  Piao, Shuyu ^a   Kim, In Gul ^a   Lee, Ji Young ^a   Hong, Sung Hoo ^a   Kim, Sae Woong ^a   Hwang, Tae Kon ^a   Oh, Se Heang ^b   Lee, Jin Ho ^b   Ra, Jeong Chan ^c   Lee, Ji Youl ^a  

^a The Catholic University of Korea   (South Korea)

^b Hannam University   (South Korea)

^c Stem Cell Research Center   (South Korea)

Author keywords

Adipose Derived Stem Cell; Brain Derived Neurotrophic Factor; Cavernous Nerve; Erectile Dysfunction

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; COLLAGEN; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NEURONAL NITRIC OXIDE SYNTHASE; PHOSPHOPROTEIN; POLOXAMER; POLYGLACTIN;

ADIPOSE DERIVED STEM CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAVERNOUS NERVE INJURY; CONTROLLED STUDY; CORPUS CAVERNOSUM; ERECTILE DYSFUNCTION; EXPERIMENTAL MODEL; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTRACAVERNOUS PRESSURE; MALE; MEAN ARTERIAL PRESSURE; MEMBRANE; NERVE CRUSH; NONHUMAN; PENIS ERECTION; PERIPHERAL NERVE INJURY; POROSITY; POSTOPERATIVE COMPLICATION; PRESSURE; PRIORITY JOURNAL; PROSTATECTOMY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE; STEM CELL TRANSPLANTATION; THERAPY EFFECT; TREATMENT OUTCOME; WESTERN BLOTTING;

EID: 84864501990     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2012.02760.x     Document Type: Article

References (39)

1. Akaza H. Aim of the working group on the Asian perspectives on cancer control: Asian perspective on prostate cancer prevention. Jpn J Clin Oncol 2010;40(suppl 1):i2-6.
2. Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, Lin X, Greenfield TK, Litwin MS, Saigal CS, Mahadevan A, Klein E, Kibel A, Pisters LL, Kuban D, Kaplan I, Wood D, Ciezki J, Shah N, Wei JT. Quality of life and satisfaction with outcome among prostate-cancer survivors. NEJM 2008;358:1250-61.
3. Bella AJ, Lin G, Lin CS, Hickling DR, Morash C, Lue TF. Nerve growth factor modulation of the cavernous nerve response to injury. J Sex Med 2009;6(suppl 3):347-52.
4. Valentine H, Chen Y, Guo H, McCormick J, Wu Y, Sezen SF, Hoke A, Burnett AL, Steiner JP. Neuroimmunophilin ligands protect cavernous nerves after crush injury in the rat: New experimental paradigms. Eur Urol 2007;51:1724-31.
5. Albersen M, Fandel TM, Zhang H, Banie L, Lin G, De Ridder D, Lin CS, Lue TF. Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction. Eur Urol 2011;59:286-96.
6. Rabbani F, Ramasamy R, Patel MI, Cozzi P, Disa JJ, Cordeiro PG, Mehrara BJ, Eastham JA, Scardino PT, Mulhall JP. Predictors of recovery of erectile function after unilateral cavernous nerve graft reconstruction at radical retropubic prostatectomy. J Sex Med 2010;7:166-81.
7. Catalona WJ, Bigg SW. Nerve-sparing radical prostatectomy: Evaluation of results after 250 patients. J Urol 1990;143:538-43; discussion 44.
8. Anastasiadis AG, Benson MC, Rosenwasser MP, Salomon L, El-Rashidy H, Ghafar MA, McKiernan JM, Burchardt M, Shabsigh R. Cavernous nerve graft reconstruction during radical prostatectomy or radical cystectomy: Safe and technically feasible. Prostate Cancer Prostatic Dis 2003;6:56-60.
9. Badani KK, Kaul S, Menon M. Evolution of robotic radical prostatectomy: Assessment after 2766 procedures. Cancer 2007;110:1951-8.
10. Walz J, Burnett AL, Costello AJ, Eastham JA, Graefen M, Guillonneau B, Menon M, Montorsi F, Myers RP, Rocco B, Villers A. A critical analysis of the current knowledge of surgical anatomy related to optimization of cancer control and preservation of continence and erection in candidates for radical prostatectomy. Eur Urol 2010;57:179-92.
11. Bochinski D, Lin GT, Nunes L, Carrion R, Rahman N, Lin CS, Lue TF. The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury. BJU Int 2004;94:904-9.
12. Lin G, Banie L, Ning H, Bella AJ, Lin CS, Lue TF. Potential of adipose-derived stem cells for treatment of erectile dysfunction. J Sex Med 2009;6(suppl 3):320-7.
13. Kendirci M, Trost L, Bakondi B, Whitney MJ, Hellstrom WJ, Spees JL. Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. J Urol 2010;184:1560-6.
14. Albersen M, Fandel TM, Lin G, Wang G, Banie L, Lin CS, Lue TF. Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 2010;7:3331-40.
15. Zannettino AC, Paton S, Arthur A, Khor F, Itescu S, Gimble JM, Gronthos S. Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo. J Cell Physiol 2008;214:413-21.
16. Chen CW, Montelatici E, Crisan M, Corselli M, Huard J, Lazzari L, Peault B. Perivascular multi-lineage progenitor cells in human organs: Regenerative units, cytokine sources or both? Cytokine Growth Factor Rev 2009;20:429-34.
17. Tholpady SS, Katz AJ, Ogle RC. Mesenchymal stem cells from rat visceral fat exhibit multipotential differentiation in vitro. Anat Rec A Discov Mol Cell Evol Biol 2003;272:398-402.
18. Yanagiuchi A, Miyake H, Nomi M, Takenaka A, Modulation FM. of the microenvironment by growth factors regulates the in vivo growth of skeletal myoblasts. BJU Int 2009;103:1569-73.
19. Suzuki T, Ooto S, Akagi T, Amemiya K, Igarashi R, Mizushima Y, Takahashi M. Effects of prolonged delivery of brain-derived neurotrophic factor on the fate of neural stem cells transplanted into the developing rat retina. Biochem Biophys Res Commun 2003;309:843-7.
20. Hsieh PS, Bochinski DJ, Lin GT, Nunes L, Lin CS, Lue TF. The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model. BJU Int 2003;92:470-5.
21. Bella AJ, Lin G, Garcia MM, Tantiwongse K, Brant WO, Lin CS, Lue TF. Upregulation of penile brain-derived neurotrophic factor (BDNF) and activation of the JAK/STAT signalling pathway in the major pelvic ganglion of the rat after cavernous nerve transection. Eur Urol 2007;52:574-80.
22. Oh SH, Kim JH, Kim JM, Lee JH. Asymmetrically porous PLGA/Pluronic F127 membrane for effective guided bone regeneration. J Biomater Sci Polym Ed 2006;17:1375-87.
23. Oh SH, Kim IG, Lee JY, Lee JH. Bioactive porous beads as an injectable urethral bulking agent: Their in vitro evaluation on smooth muscle cell differentiation. Tissue Eng Part A 2011;17:655-64.
24. Eddahibi S, Hanoun N, Lanfumey L, Lesch KP, Raffestin B, Hamon M, Adnot S. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest 2000;105:1555-62.
25. Huang YC, Ning H, Shindel AW, Fandel TM, Lin G, Harraz AM, Lue TF, Lin CS. The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model. J Sex Med 2010;7:1391-400.
26. Kim JH, Bennett N, Yoshimura N, Chermansky C, Kwon DD, Tarin T, Nelson JB, DeGroat WC, Qu-Petersen Z, Huard J, Chancellor MB. Neurorecovery and improved erectile function using muscle derived stem cells (MDSC) in a model of post-radical prostatectomy erectile dysfunction. J Urol 2003;169:323 [Abstract 1256].
27. Schuldiner M, Yanuka O, Itskovitz-Eldor J, Melton DA, Benvenisty N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A 2000;97:11307-12.
28. Kubota H, Avarbock MR, Brinster RL. Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A 2004;101:16489-94.
29. Ra JC, Shin IS, Kim SH, Kang SK, Kang BC, Lee HY, Kim YJ, Jo JY, Yoon EJ, Choi HJ, Kwon E. Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans. Stem Cells Dev 2011;20:1297-308.
30. Ignatius AA, Claes LE. In vitro biocompatibility of bioresorbable polymers: Poly(L, DL-lactide) and poly(L-lactide-co-glycolide). Biomaterials 1996;17:831-9.
31. Owen GR, Jackson J, Chehroudi B, Burt H, Brunette DM. A PLGA membrane controlling cell behaviour for promoting tissue regeneration. Biomaterials 2005;26:7447-56.
32. Hwang JH, Kim IG, Lee JY, Piao S, Lee DS, Lee TS, Ra JC. Therapeutic lymphangiogenesis using stem cell and VEGF-C hydrogel. Biomaterials 2011;32:4415-23.
33. Huang Q, Goh JC, Hutmacher DW, Lee EH. In vivo mesenchymal cell recruitment by a scaffold loaded with transforming growth factor beta1 and the potential for in situ chondrogenesis. Tissue Eng 2002;8:469-82.
34. Lue TF. Erectile dysfunction. N Engl J Med 2000;342:1802-13.
35. Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1990;170:843-50.
36. Magee TR, Ferrini MG, Davila HH, Zeller CB, Vernet D, Sun J, Lalani R, Burnett AL, Rajfer J, Gonzalez-Cadavid NF. Protein inhibitor of nitric oxide synthase (NOS) and the N-methyl-D-aspartate receptor are expressed in the rat and mouse penile nerves and colocalize with penile neuronal NOS. Biol Reprod 2003;68:478-88.
37. Hurt KJ, Musicki B, Palese MA, Crone JK, Becker RE, Moriarity JL, Snyder SH, Burnett AL. Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection. Proc Natl Acad Sci U S A 2002;99:4061-6.
38. Jesmin S, Sakuma I, Salah-Eldin A, Nonomura K, Hattori Y, Kitabatake A. Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: A possible cause for erectile dysfunction in diabetes. J Mol Endocrinol 2003;31:401-18.
39. Jin HR, Kim WJ, Song JS, Piao S, Tumurbaatar M, Shin SH, Choi MJ, Tuvshintur B, Song KM, Kwon MH, Yin GN, Koh GY, Ryu JK, Suh JK. Intracavernous delivery of synthetic angiopoietin-1 protein as a novel therapeutic strategy for erectile dysfunction in the type II diabetic db/db mouse. J Sex Med 2010;7:3635-46.