The affinity of histamine for Gq protein-coupled histamine H 1-receptors is predominantly regulated by their internalization in human astrocytoma cells

Journal of Pharmacological Sciences

Volumn 119, Issue 3, 2012, Pages 233-242

  Hishinuma, Shigeru ^a   Sato, Yuko ^a   Akatsu, Chizuru ^a   Shoji, Masaru ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Agonist affinity; Desensitization; G protein coupled receptor; Internalization

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CLATHRIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; HISTAMINE; HISTAMINE H1 RECEPTOR; MEPYRAMINE; ZINC CHLORIDE;

ARTICLE; ASTROCYTOMA CELL; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME INHIBITION; HOMEOSTASIS; HUMAN; HUMAN CELL; IC 50; INTERNALIZATION; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY; REGULATORY MECHANISM;

EID: 84864496050     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11054FP     Document Type: Article

References (37)

1. Lefkowitz RJ. Seven transmembrane receptors: something old, something new. Acta Physiol. 2007;190:9-19. (Pubitemid 46570176)
2. Rajagopal S, Rajagopal K, Lefkowitz RJ. Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov. 2010;9:373-386.
3. Reiter E, Lefkowitz RJ. GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab. 2006;17:159-165.
4. Moore CA, Milano SK, Benovic JL. Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol. 2007;69:451-482. (Pubitemid 46457651)
5. Shenoy SK. Seven-transmembrane receptors and ubiquitination. Circ Res. 2007;100:1142-1154. (Pubitemid 46684127)
6. Hill SJ. Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol Rev. 1990;42:45-83. (Pubitemid 20209593)
7. Bakker RA, Timmerman H, Leurs R. Histamine receptors: specific ligands, receptor biochemistry, and signal transduction. Clin Allergy Immunol. 2002;17:27-64.
8. Hishinuma S, Uchida MK. Effects of local anaesthetics on short-term desensitization of guinea-pig taenia caecum to histamine. Br J Pharmacol. 1987;92:733-741. (Pubitemid 18014923)
9. 1-receptors. Br J Pharmacol. 1988;94:882-889.
10. Horio S, Nakamura S, Ishida Y. Alterations in histamine receptors of guinea-pig ileal smooth muscle produced during agonist-induced desensitization. Br J Pharmacol. 1990;101:587-590. (Pubitemid 20357180)
11. 1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways. Br J Pharmacol. 1992;107:448-455.
12. 1-receptor internalisation. Br J Pharmacol. 1995;116:2715-2723.
13. 1-receptor in GT1-7 neuronal cells is regulated by calcium influx and KN-62, a putative inhibitor of calcium/calmodulin protein kinase II. Br J Pharmacol. 1996;118:1119-1126.
14. 1 receptor stably expressed in Chinese hamster ovary cells. Br J Pharmacol. 1996;117:1071-1080.
15. 1 receptors in human U373 MG astrocytoma cells. J Neurochem. 1998;71:2626-2633.
16. 2+ responses in human U373 MG astrocytoma cells. J Neurochem. 2000;75:772-781.
17. Horio S, Ogawa M, Kawakami N, Fujimoto K, Fukui H. Identification of amino acid residues responsible for agonist-induced down-regulation of histamine H1 receptors. J Pharmacol Sci. 2004;94:410-419. (Pubitemid 38590761)
18. Horio S, Kato T, Ogawa M, Fujimoto K, Fukui H. Two thereonine residues and two serine residues in the second and third intracellular loops are both involved in histamine H1 receptor downregulation. FEBS Lett. 2004;573:226-230. (Pubitemid 39141062)
19. 1-receptor in CHO-K1 cells. Br J Pharmacol. 2005;146:612-624.
20. 1 histamine receptor by G protein-coupled receptor kinase 2. J Biol Chem. 2005;280:2197-2204.
21. 1 histamine receptor signaling by G protein-coupled receptor kinase 2 in uterine smooth muscle cells. Mol Endocrinol. 2008;22:1893-1907.
22. Hishinuma S, Saito M. Histamine-induced progression from heterologous to homologous desensitization of contraction in smooth muscle of guinea-pig taenia caeci. Clin Exp Pharmacol Physiol. 2008;35:1331-1336.
23. 1-receptors in Chinese hamster ovary cells. J Neurochem. 2010;113:990-1001.
24. 1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008;107:66-79.
25. Benovic JL, Mayor F, Staniszewski C, Lefkowitz RJ, Caron MG. Purification and characterization of the beta-adrenergic receptor kinase. J Biol Chem. 1987;262:9026-9032.
26. Hasbi A, Polastron J, Allouche S, Stanasila L, Massotte D, Jauzac P. Desensitization of the delta-opioid receptor correlates with its phosphorylation in SK-N-BE cells: involvement of a G proteincoupled receptor kinase. J Neurochem. 1998;70:2129-2138. (Pubitemid 28207838)
27. Shayo C, Fernandez N, Legnazzi BL, Monczor F, Mladovan A, Baldi A, et al. Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases. Mol Pharmacol. 2001;60:1049-1056. (Pubitemid 33027440)
28. 2+/calmodulin-dependent protein kinase II. J Biol Chem. 1990;265:4315-4320.
29. Wolfe BL, Trejo J. Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis. Traffic. 2007;8:462-470. (Pubitemid 46638559)
30. Heuser JE, Anderson RGW. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J Cell Biol. 1989;108:389-400. (Pubitemid 19065841)
31. Slowiejko DM, McEwen EL, Ernst SA, Fisher SK. Muscarinic receptor sequestration in SH-SY5Y neuroblastoma cells is inhibited when clathrin distribution is perturbed. J Neurochem. 1996;88:186-196. (Pubitemid 26010780)
32. Hishinuma S, Matsumoto Y, Uchida MK, Kurokawa M. Novel regulation of muscarinic receptors and their coupling with G proteins in smooth muscle: transient resensitization during desensitizing process. Br J Pharmacol. 1993;109:330-335. (Pubitemid 23161114)
33. Strange PG. G-protein coupled receptors: conformations and states. Biochem Pharmacol. 1999;58:1081-1088. (Pubitemid 29381509)
34. 35S] GTPγS binding assays. Trends Pharmacol Sci. 2003;24:87-90.
35. 2-adrenergic receptor dephosphorylation by vesicular acidification. J Biol Chem. 1997;272:5-8.
36. 2-adrenergic receptors permit receptor resensitization. Mol Pharmacol. 1995;47:666-676.
37. Pitcher JA, Payne ES, Csortos C, DePaoli-Roach AA, Lefkowitz RJ. The G protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proc Natl Acad Sci U S A. 1995;92:8343-8347.