A contemporary view on endothelial function in heart failure

European Journal of Heart Failure

Volumn 14, Issue 8, 2012, Pages 873-881

  Shantsila, Eduard ^a   Wrigley, Benjamin J ^a   Blann, Andrew D ^a   Gill, Paramjit S ^a   Lip, Gregory Y H ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Endothelial dysfunction; Heart failure; Inflammation; Oxidative stress

Indexed keywords

ACETYLCHOLINE; ALLOPURINOL; ALPHA TOCOPHEROL; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ARGININE; ASCORBIC ACID; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DARUSENTAN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIN 1; ETANERCEPT; EZETIMIBE; GLYCERYL TRINITRATE; GROWTH HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ROSUVASTATIN; SILDENAFIL; SIMVASTATIN; SPIRONOLACTONE; VON WILLEBRAND FACTOR;

ARTERY BLOOD FLOW; BRACHIAL ARTERY; BRACHIAL ARTERY FLOW MEDIATED DILATION; CARDIAC RESYNCHRONIZATION THERAPY; CLINICAL TRIAL (TOPIC); COMORBIDITY; CONGESTIVE HEART FAILURE; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; DOSE RESPONSE; DRUG MEGADOSE; DRUG TREATMENT FAILURE; ENDOTHELIAL DYSFUNCTION; EXERCISE; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; HUMAN; LOW DRUG DOSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SHEAR STRESS; UPREGULATION; VASCULAR ENDOTHELIUM; VASODILATATION; VITAMIN SUPPLEMENTATION; WALKING;

BIOLOGICAL MARKERS; ENDOTHELIUM, VASCULAR; HEART FAILURE; HUMANS; INFLAMMATION; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS;

EID: 84864481199     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfs066     Document Type: Review

References (50)

1. Wisloff U, Stoylen A, Loennechen JP, Bruvold M, Rognmo O, Haram PM, Tjonna AE, Helgerud J, Slordahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen O, Skjaerpe T. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 2007;115:3086-3094.
2. Strey CH, Young JM, Molyneux SL, George PM, Florkowski CM, Scott RS, Frampton CM. Endothelium-ameliorating effects of statin therapy and coenzyme Q10 reductions in chronic heart failure. Atherosclerosis 2005;179:201-206.
3. Linke A, Recchia F, Zhang X, Hintze TH. Acute and chronic endothelial dysfunction: implications for the development of heart failure. Heart Fail Rev 2003;8: 87-97.
4. Shantsila E, Lip GY. The endothelium and thrombotic risk in heart failure. Thromb Haemost 2009;102:185-187.
5. Apostolakis S, Lip GY, Shantsila E. Monocytes in heart failure: relationship to a deteriorating immune overreaction or a desperate attempt for tissue repair? Cardiovasc Res 2010;85:649-660.
6. Chong AY, Blann AD, Patel J, Freestone B, Hughes E, Lip GY. Endothelial dysfunction and damage in congestive heart failure: relation of flow-mediated dilation to circulating endothelial cells, plasma indexes of endothelial damage, and brain natriuretic peptide. Circulation 2004;110:1794-1798.
7. Shah A, Gkaliagkousi E, Ritter JM, Ferro A. Endothelial function and arterial compliance are not impaired in subjects with heart failure of non-ischemic origin. J Card Fail 2010;16:114-120.
8. Klosinska M, Rudzinski T, Grzelak P, Stefanczyk L, Drozdz J, Krzeminska-Pakula M. Endothelium-dependent and-independent vasodilation is more attenuated in ischaemic than in non-ischaemic heart failure. Eur J Heart Fail 2009;11:765-770.
9. Canetti M, Akhter MW, Lerman A, Karaalp IS, Zell JA, Singh H, Mehra A, Elkayam U. Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy. Am J Cardiol 2003;92:1246-1249.
10. Dini FL, Ghiadoni L, Conti U, Stea F, Buralli S, Taddei S, De Tommasi SM. Coronary flow reserve in idiopathic dilated cardiomyopathy: relation with left ventricular wall stress, natriuretic peptides, and endothelial dysfunction. J Am Soc Echocardiogr 2009;22:354-360.
11. Bitar F, Lerman A, Akhter MW, Hatamizadeh P, Janmohamed M, Khan S, Elkayam U. Variable response of conductance and resistance coronary arteries to endothelial stimulation in patients with heart failure due to nonischemic dilated cardiomyopathy. J Cardiovasc Pharmacol Ther 2006;11:197-202.
12. Souders CA, Bowers SL, Baudino TA. Cardiac fibroblast: the renaissance cell. Circ Res 2009;105:1164-1176.
13. Kwan CY, Hsieh WT, To PN, Wang HD. New perspectives on vascular wall signaling: role of perivascular adipocytes and fibroblasts. Acta Pharmacol Sin 2010;31: 1022-1025.
14. Mathier MA, Rose GA, Fifer MA, Miyamoto MI, Dinsmore RE, Castano HH, Dec GW, Palacios IF, Semigran MJ. Coronary endothelial dysfunction in patients with acute-onset idiopathic dilated cardiomyopathy. J Am Coll Cardiol 1998;32: 216-224.
15. Elesber AA, Redfield MM, Rihal CS, Prasad A, Lavi S, Lennon R, Mathew V, Lerman LO, Lerman A. Coronary endothelial dysfunction and hyperlipidemia are independently associated with diastolic dysfunction in humans. Am Heart J 2007;153:1081-1087.
16. Ma LN, Zhao SP, Gao M, Zhou QC, Fan P. Endothelial dysfunction associated with left ventricular diastolic dysfunction in patients with coronary heart disease. Int J Cardiol 2000;72:275-279.
17. Lapu-Bula R, Ofili E. From hypertension to heart failure: role of nitric oxidemediated endothelial dysfunction and emerging insights from myocardial contrast echocardiography. Am J Cardiol 2007;99:7D-14D.
18. Colombo PC, Rastogi S, Onat D, Zaca V, Gupta RC, Jorde UP, Sabbah HN. Activation of endothelial cells in conduit veins of dogs with heart failure and veins of normal dogs after vascular stretch by acute volume loading. J Card Fail 2009;15:457-463.
19. Dworakowski R, Walker S, Momin A, Desai J, El-Gamel A, Wendler O, Kearney MT, Shah AM. Reduced nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide and vascular endothelial dysfunction in human heart failure. J Am Coll Cardiol 2008;51:1349-1356.
20. Rabelo ER, Ruschel K, Moreno H, Jr., Rubira M, Consolim-Colombo FM, Irigoyen MC, Rohde LE. Venous endothelial function in heart failure: comparison with healthy controls and effect of clinical compensation. Eur J Heart Fail 2008;10: 758-764.
21. Nightingale AK, Blackman DJ, Ellis GR, Schmitt M, Morris-Thurgood JA, Jones EA, Frenneaux MP. Preservation of venous endothelial function in the forearm venous capacitance bed of patients with chronic heart failure despite arterial endothelial dysfunction. J Am Coll Cardiol 2001;37:1062-1068.
22. Andersson SE, Edvinsson ML, Edvinsson L. Cutaneous vascular reactivity is reduced in aging and in heart failure: association with inflammation. Clin Sci (Lond) 2003;105:699-707.
23. Kielstein JT, Bode-Boger SM, Klein G, Graf S, Haller H, Fliser D. Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure. Eur J Clin Invest 2003;33:370-375.
24. Nakamura M, Sugawara S, Arakawa N, Nagano M, Shizuka T, Shimoda Y, Sakai T, Hiramori K. Reduced vascular compliance is associated with impaired endothelium-dependent dilatation in the brachial artery of patients with congestive heart failure. J Card Fail 2004;10:36-42.
25. Shechter M, Matetzky S, Arad M, Feinberg MS, Freimark D. Vascular endothelial function predicts mortality risk in patients with advanced ischaemic chronic heart failure. Eur J Heart Fail 2009;11:588-593.
26. Kubrich M, Petrakopoulou P, Kofler S, Nickel T, Kaczmarek I, Meiser BM, Reichart B, von Scheidt W, Weis M. Impact of coronary endothelial dysfunction on adverse long-term outcome after heart transplantation. Transplantation 2008; 85:1580-1587.
27. Tio RA, Dabeshlim A, Siebelink HM, de Sutter J, Hillege HL, Zeebregts CJ, Dierckx RA, van Veldhuisen DJ, Zijlstra F, Slart RH. Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease. J Nucl Med 2009;50:214-219.
28. Kistorp C, Chong AY, Gustafsson F, Galatius S, Raymond I, Faber J, Lip GY, Hildebrandt P. Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes. Eur J Heart Fail 2008;10:380-387.
29. Chong AY, Freestone B, Lim HS, Kistorp C, Gustafsson F, Hildebrandt P, Lip GY. Plasma von Willebrand factor and soluble E-selectin levels in stable outpatients with systolic heart failure: the Frederiksberg heart failure study. Int J Cardiol 2007;119:80-82.
30. Chong AY, Freestone B, Patel J, Lim HS, Hughes E, Blann AD, Lip GY. Endothelial activation, dysfunction, and damage in congestive heart failure and the relation to brain natriuretic peptide and outcomes. Am J Cardiol 2006;97:671-675.
31. Chong AY, Lip GY, Freestone B, Blann AD. Increased circulating endothelial cells in acute heart failure: comparison with von Willebrand factor and soluble E-selectin. Eur J Heart Fail 2006;8:167-172.
32. Poelzl G, Frick M, Lackner B, Huegel H, Alber HF, Mair J, Herold M, Schwarzacher SP, Pachinger O,Weidinger F. Short-term improvement in submaximal exercise capacity by optimized therapy with ACE inhibitors and beta blockers in heart failure patients is associated with restoration of peripheral endothelial function. Int J Cardiol 2006;108:48-54.
33. Kjekshus J, Apetrei E, Barrios V, Bohm M, Cleland JG, Cornel JH, Dunselman P, Fonseca C, Goudev A, Grande P, Gullestad L, Hjalmarson A, Hradec J, Janosi A, Kamensky G, Komajda M, Korewicki J, Kuusi T, Mach F, Mareev V, McMurray JJ, Ranjith N, Schaufelberger M, Vanhaecke J, van Veldhuisen DJ, Waagstein F, Wedel H, Wikstrand J. Rosuvastatin in older patients with systolic heart failure. N Engl J Med 2007;357:2248-2261.
34. Bleske BE, Nicklas JM, Bard RL, Brook RD, Gurbel PA, Bliden KP, Rajagopalan S, Pitt B. Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average lowdensity lipoprotein level. J Am Coll Cardiol 2006;47:338-341.
35. Erbs S, Beck EB, Linke A, Adams V, Gielen S, Krankel N, Mobius-Winkler S, Hollriegel R, Thiele H, Hambrecht R, Schuler G. High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling-results from a randomized, double-blind, and placebo-controlled study. Int J Cardiol 2011;146:56-63.
36. Gounari P, Tousoulis D, Antoniades C, Kampoli AM, Stougiannos P, Papageorgiou N, Roulia G, Stefanadi E, Siasos G, Tsioufis C, Stefanadis C. Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering. Int J Cardiol 2010;142: 87-91.
37. Young JM, Strey CH, George PM, Florkowski CM, Sies CW, Frampton CM, Scott RS. Effect of atorvastatin on plasma levels of asymmetric dimethylarginine in patients with non-ischaemic heart failure. Eur J Heart Fail 2008;10:463-466.
38. Landmesser U, Bahlmann F, Mueller M, Spiekermann S, Kirchhoff N, Schulz S, Manes C, Fischer D, de Groot K, Fliser D, Fauler G, Marz W, Drexler H. Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation 2005;111:2356-2363.
39. Shantsila E, Watson T, Lip GY. Endothelial progenitor cells in cardiovascular disorders. J Am Coll Cardiol 2007;49:741-752.
40. Cittadini A, Monti MG, Petrillo V, Esposito G, Imparato G, Luciani A, Urciuolo F, Bobbio E, Natale CF, Sacca L, Netti PA. Complementary therapeutic effects of dual delivery of insulin-like growth factor-1 and vascular endothelial growth factor by gelatin microspheres in experimental heart failure. Eur J Heart Fail 2011;13:1264-1274.
41. Tai MK, Meininger JC, Frazier LQ. A systematic review of exercise interventions in patients with heart failure. Biol Res Nurs 2008;10:156-182.
42. Sarto P, Balducci E, Balconi G, Fiordaliso F, Merlo L, Tuzzato G, Pappagallo GL, Frigato N, Zanocco A, Forestieri C, Azzarello G, Mazzucco A, Valenti MT, Alborino F, Noventa D, Vinante O, Pascotto P, Sartore S, Dejana E, Latini R. Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure. J Card Fail 2007;13:701-708.
43. Van Craenenbroeck EM, Hoymans VY, Beckers PJ, Possemiers NM, Wuyts K, Paelinck BP, Vrints CJ, Conraads VM. Exercise training improves function of circulating angiogenic cells in patients with chronic heart failure. Basic Res Cardiol 2010;105:665-676.
44. Erbs S, Hollriegel R, Linke A, Beck EB, Adams V, Gielen S, Mobius-Winkler S, Sandri M, Krankel N, Hambrecht R, Schuler G. Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function. Circ Heart Fail 2010;3:486-494.
45. Niebauer J, Clark AL,Webb-Peploe KM, Coats AJ. Exercise training in chronic heart failure: effects on pro-inflammatory markers. Eur J Heart Fail 2005;7:189-193.
46. de Berrazueta JR, Guerra-Ruiz A, Garcia-Unzueta MT, Toca GM, Laso RS, de Adana MS, Martin MA, Cobo M, Llorca J. Endothelial dysfunction, measured by reactive hyperaemia using strain-gauge plethysmography, is an independent predictor of adverse outcome in heart failure. Eur J Heart Fail 2010;12:477-483.
47. Heitzer T, Baldus S, von Kodolitsch Y, Rudolph V, Meinertz T. Systemic endothelial dysfunction as an early predictor of adverse outcome in heart failure. Arterioscler Thromb Vasc Biol 2005;25:1174-1179.
48. Katz SD, Hryniewicz K, Hriljac I, Balidemaj K, Dimayuga C, Hudaihed A, Yasskiy A. Vascular endothelial dysfunction and mortality risk in patients with chronic heart failure. Circulation 2005;111:310-3314.
49. Fischer D, Rossa S, Landmesser U, Spiekermann S, Engberding N, Hornig B, Drexler H. Endothelial dysfunction in patients with chronic heart failure is independently associated with increased incidence of hospitalization, cardiac transplantation, or death. Eur Heart J 2005;26:65-69.
50. Vila V, Martinez-Sales V, Almenar L, Lazaro IS, Villa P, Reganon E. Inflammation, endothelial dysfunction and angiogenesis markers in chronic heart failure patients. Int J Cardiol 2008;130:276-277.