Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering

International Journal of Cardiology

Volumn 142, Issue 1, 2010, Pages 87-91

  Gounari, Panagiota ^a   Tousoulis, Dimitris ^a   Antoniades, Charalambos ^a   Kampoli, Anna Maria ^a   Stougiannos, Pavlos ^a   Papageorgiou, Nikos ^a   Roulia, Georgia ^a   Stefanadi, Elli ^a   Siasos, Gerasimos ^a   Tsioufis, Costas ^a   Stefanadis, Christodoulos ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Endothelium; Ezetimibe; Lipids; Rosuvastatin

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; EZETIMIBE; GLYCERYL TRINITRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; ROSUVASTATIN; TRIACYLGLYCEROL;

ADULT; ARTERY BLOOD FLOW; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR ENDOTHELIUM;

AZETIDINES; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; FLUOROBENZENES; HEART FAILURE; HUMANS; LIPIDS; MALE; MIDDLE AGED; PYRIMIDINES; SULFONAMIDES; VASODILATION;

EID: 77953285918     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2008.12.067     Document Type: Article

References (19)

1. Elkayam U., Khan S., Menhoob A., and Ahsan N. Impaired endothelium-mediated vasodilation in heart failure: clinical evidence and the potential for therapy. J Card Fail 8 1 (2002) 15-20
2. Bauersachs J., and Widder J.D. Endothelial dysfunction in heart failure. Pharmacol Rep 60 1 (2008) 119-126
3. Tousoulis D., Antoniades C., and Stefanadis C. Evaluating endothelial function in humans: a guide to invasive and non-invasive techniques. Heart 91 4 (2005) 553-558
4. Tentolouris C., Tousoulis D., Antoniades C., et al. Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy. Int J Cardiol 94 (2004) 301-305
5. Drexler H, Hornig B. Endothelial dysfunction in human disease. J Mol Cell Cardiol 31:51-60.
6. Khush K.K., and Waters D.D. Effects of statin therapy on the development and progression of heart failure: mechanisms and clinical trials. J Card Fail 12 8 (2006) 664-674
7. von Haehling S., Anker S.D., and Bassenge E. Statins and the role of nitric oxide in chronic heart failure. Heart Fail Rev 8 (2003) 99-106
8. Dhalla A.K., Hill M.F., and Singal P.K. Role of oxidative stress in transition of hypertrophy to heart failure. J Am Coll Cardiol 28 (1996) 506-514
9. Ferrari R., Agnoletti L., Comini L., et al. Oxidative stress during myocardial ischemia and heart failure. Eur Heart J 19 (1998) B2-B11
10. Lefer A.M., Scalia R., and Lefer D.J. Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease. Cardiovasc Res 49 (2001) 281-287
11. Bates K., Ruggeroli C.E., Goldman S., and Gaballa M.A. Simvastatin restores endothelial NO-mediated vasorelaxation in large arteries after myocardial infarction. Am J Physiol Heart Circ Physiol 283 (2002) H768-H775
12. Trochu J.N., Mital S., Zhang X., Xu X., Ochoa M., and Liao J.K. Preservation of NO production by statins in the treatment of heart failure. Cardiovasc Res 60 (2003) 250-258
13. Tousoulis D., Antoniades C., Bosinakou E., et al. Effects of atorvastatin on reactive hyperaemia and the thrombosis-fibrinolysis system in patients with heart failure. Heart 91 (2005) 27-31
14. Tousoulis D., Antoniades C., Bosinakou E., et al. Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure. Atherosclerosis 178 2 (2005) 359-363
15. Strey C.H., Young J.M., Lainchbury J.H., et al. Short-term statin treatment improves endothelial function and neurohormonal imbalance in normocholesterolaemic patients with non-ischaemic heart failure. Heart 92 11 (2006) 1603-1609
16. ter Avest E., Abbink E.J., Holewijn S., de Graaf J., Tack C.J., and Stalenhoef A.F. Effects of rosuvastatin on endothelial function in patients with familial combined hyperlipidaemia (FCH). Curr Med Res Opin 21 9 (2005) 1469-1476
17. Bulut D., Hanefeld C., Bulut-Streich N., Graf C., Mügge A., and Spiecker M. Endothelial function in the forearm circulation of patients with the metabolic syndrome-effect of different lipid-lowering regimens. Cardiology 104 4 (2005) 176-180
18. Landmesser U., Bahlmann F., Mueller M., et al. Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation 111 18 (2005) 2356-2363
19. Coats A.J. Ethical authorship and publishing. Int J Cardiol 131 (2009) 149-150