High concentration formulation studies of an IgG2 antibody using small angle x-ray scattering

Pharmaceutical Research

Volumn 29, Issue 8, 2012, Pages 2225-2235

  Mosbaek, Charlotte Rode ^a,b   Konarev, Petr V ^c   Svergun, Dmitri I ^c   Rischel, Christian ^b   Vestergaard, Bente ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Antibody; IgG2; Protein formulation; Small angle x ray scattering (SAXS); Solution characterization

Indexed keywords

EXCIPIENT; PANITUMUMAB;

ARTICLE; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CONFORMATION; DRUG FORMULATION; DRUG STRUCTURE; FLUORESCENCE; GEL PERMEATION CHROMATOGRAPHY; LIGHT SCATTERING; OLIGOMERIZATION; PH; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; HUMANS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SCATTERING, SMALL ANGLE; SOLUTIONS; SPECTROMETRY, FLUORESCENCE; X-RAY DIFFRACTION;

EID: 84864478612     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0751-3     Document Type: Article

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