Preparation and characterization of 5-fluorouracil pH-sensitive niosome and its tumor-targeted evaluation: In vitro and in vivo

Drug Development and Industrial Pharmacy

Volumn 38, Issue 9, 2012, Pages 1134-1141

  Wang, Mi ^a   Yuan, Yue ^a   Gao, Yang ^a   Ma, Hong Mei ^a   Xu, Hong Tao ^a   Zhang, Xiao Ning ^b   Pan, Wei San ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Tsinghua University   (China)

Author keywords

CHEMS; in vitro release; Niosomes; PH sensitive; Tumor targeted evaluation

Indexed keywords

FLUOROURACIL; NIOSOME;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; DRUG SCREENING; DRUG SYNTHESIS; DRUG TISSUE LEVEL; ENCAPSULATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PARTICLE SIZE; PH; PROTON NUCLEAR MAGNETIC RESONANCE; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CHOLESTEROL ESTERS; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FLUOROURACIL; HUMANS; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MICE; MICE, INBRED STRAINS; MOLECULAR CONFORMATION; NEOPLASMS; PARTICLE SIZE; RANDOM ALLOCATION; SOLUBILITY; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864474835     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.641565     Document Type: Article

References (28)

1. Carafa M, Di Marzio L, Marianecci C, Cinque B, Lucania G, Kajiwara K et al. (2006). Designing novel pH-sensitive non-phospholipid vesicle: Characterization and cell interaction. Eur J Pharm Sci, 28:385-393.
2. Wolff JA. (2000). Compositions and methods for delivery of drugs and nucleic acids using pH sensitive molecules. PCT Int Appl
3. Mastrobattista E, Koning GA, van Bloois L, Filipe AC, Jiskoot W, Storm G. (2002). Functional characterization of an ndosomedisruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins. J Biol Chem, 277:27135-27143.
4. Parente RA, Nadasdi L, Subbarao NK, Szoka FC Jr. (1990). Association of a pH-sensitive peptide with membrane vesicles: Role of amino acid sequence. Biochemistry, 29:8713-8719.
5. Leroux J, Roux E, Le Garrec D, Hong K, Drummond DC. (2001). N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles. J Control Release, 72:71-84.
6. Francis MF, Dhara G, Winnik FM, Leroux JC. (2001). In vitro evaluation of pH-sensitive polymer/niosome complexes. Biomacromolecules, 2:741-749.
7. Ismail MH, Pieter RC. (2000). Cholesteryl hemisuccinate exhibits pH sensitive polymorphic phase behavior. Biochim Biophys Acta, 1463:107-114.
8. Donatella P, Donato C, Rita M, Elena T, Nevio P, Massimo F. (2008). Innovative bola-surfactant niosomes as topical delivery system of 5-fluorouracil for the treatment of skin cancer. Int J Pharm 353:233-242.
9. Kempen HJ, Hoes C, van Boom JH, Spanjer HH, de Lange J, Langendoen A et al. (1984). A water-soluble cholesteryl-containing trisgalactoside: Synthesis, properties, and use in directing lipidcontaining particles to the liver. J Med Chem, 27:1306-1312.
10. Carafa M, Marianecci C, Lucania G, Marchei E, Santucci E. (2004). New vesicular ampicillin-loaded delivery systems for topical application: Characterization, in vitro permeation experiments and antimicrobial activity. J Control Release, 95:67-74.
11. Xu H, Deng YH, Chen DW, Qin J, Liu JF, Shi L, Lu Y. (2008). Preparation and characterization of pH-sensitive vesicles made of cholesteryl hemisuccinate. Drug Dev Ind Pharm, 34:134-141.
12. Gabriela DV, Laura H, Alcira B, Haydée F, María VD, Leandro M, et al. (2008). Characterisation of liposomes containing aminolevulinic acid and derived esters. J Photochem Photobiol, 92:1-9.
13. Levy MY, Benita S. (1990). Drug release from submicronized o/w emulsion: A new in vitro kinetic evaluation model. Int J Pharm, 66:29-37.
14. Washington C. (1990). Drug release from microdisperse systems: A critical review. Int J Pharm, 58:1-12.
15. Yamada K, Arita K, Kobuchi H, Yamamoto S, Yoshioka T, Tamai H et al. (2003). Cholesteryl-hemisuccinate-induced apoptosis of promyelocytic leukemia HL-60 cells through a cyclosporin A-insensitive mechanism. Biochem Pharmacol, 65:339-348.
16. Arunothayanun P, Uchegbu IF, Craig DQ, Turton JA, Florence AT. (1999). In vitro/in vivo characterisation of polyhedral niosomes. Int J Pharm, 183:57-61.
17. Jain S, Singh P, Mishra V, Vyas SP. (2005). Mannosylated niosomes as adjuvant-carrier system for oral genetic immunization against hepatitis B. Immunol Lett, 101:41-49.
18. Uchegbu IF, Duncan R. (1997). Niosomes containing N-(2-hydroxypropyl) methacrylamide copolymer-doxorubicin (PK1): Effect of method of preparation and choice of surfactant on niosome characteristics and a preliminary study of body distribution [J]. Int J Pharm, 155:7-17.
19. Vora B, Khopade AJ, Jain NK. (1998). Proniosome based transdermal delivery of levonorgestrel for effective contraception. J Control Release, 54:149-165.
20. Devaraj GN, Parakh SR, Devraj R, Apte SS, Rao BR, Rambhau D. (2002). Release studies on niosomes containing fatty alcohols as bilayer stabilizers instead of cholesterol. J Colloid Interface Sci, 251:360-365.
21. Fang JY, Hong CT, Chiu WT, Wang YY. (2001). Effect of liposomes and niosomes on skin permeation of enoxacin. Int J Pharm, 219:61-72.
22. Dufes C, Schätzlein AG, Tetley L, Gray AI, Watson DG, Olivier JC et al. (2000). Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting. Pharm Res, 17:1250-1258.
23. Uchegbu IF. (1998). The biodistribution of novel 200-nm palmitoyl muramic acid vesicles [J]. Int J Pharm, 162:19-27.
24. Lai MZ, Düzgünes N, Szoka FC. (1985). Effects of replacement of the hydroxyl group of cholesterol and tocopherol on the thermotropic behavior of phospholipid membranes. Biochemistry, 24:1646-1653.
25. Renshaw PF, Janoff AS, Miller KW. (1983). On the nature of dilute aqueous cholesterol suspensions. J Lipid Res, 24:47-51.
26. Huang C, Li S. (1999). Calorimetric and molecular mechanics studies of the thermotropic phase behavior of membrane phospholipids. Biochim Biophys Acta, 1422:273-307.
27. Klajnert B, Janiszewska J, Urbanczyk-Lipkowska Z, Bryszewska M, Epand RM. (2006). DSC studies on interactions between low molecular mass peptide dendrimers and model lipid membranes. Int J Pharm, 327:145-152.
28. Zhuang CY, Li N, Wang M, Zhang XN, Pan WS, Peng JJ, et al. (2010). Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability. Int J Pharm, 394:179-185.