Genome-wide screen of human bromodomain-containing proteins identifies Cecr2 as a novel DNA damage response protein

Molecules and Cells

Volumn 34, Issue 1, 2012, Pages 85-91

  Lee, Seul Ki ^a   Park, Eun Jung ^a   Lee, Han Sae ^a   Lee, Ye Seul ^a   Kwon, Jongbum ^a  

^a Ewha Womans University   (South Korea)

Author keywords

bromodomain; Cecr2; DNA damage response; gamma H2AX; genome wide screen

Indexed keywords

BRG1 PROTEIN; DOUBLE STRANDED DNA; HISTONE H2AX; HISTONE H3; LYSINE; NUCLEAR PROTEIN; PROTEIN CAT EYE SYNDROME CHROMOSOME REGION CANDIDATE 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL FUNCTION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENE SILENCING; GENETIC ASSOCIATION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; NUCLEOSOME; PROTEIN BINDING; PROTEIN EXPRESSION; SCREENING;

CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; DNA HELICASES; DNA REPAIR; GENOME-WIDE ASSOCIATION STUDY; HEK293 CELLS; HISTONES; HUMANS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; TRANSCRIPTION FACTORS;

EID: 84864471033     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-012-0112-4     Document Type: Article

References (26)

1. G.S. Banting O. Barak T.M. Ames A.C. Burnham M.D. Kardel N.S. Cooch C.E. Davidson R. Godbout H.E. McDermid R. Shiekhattar 2005 CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L Hum. Mol. Genet. 14 513 524 15640247 10.1093/hmg/ddi048 1:CAS:528:DC%2BD2MXhtV2qs7g%3D (Pubitemid 40277467)
2. Y. Bao X. Shen 2007 Chromatin remodeling in DNA double-strand break repair Curr. Opin. Genet. Dev. 17 126 131 17320375 10.1016/j.gde.2007.02.010 1:CAS:528:DC%2BD2sXkt1ahsr4%3D (Pubitemid 46551721)
3. M. Bienz 2006 The PHD finger, a nuclear protein-interaction domain Trends Biochem. Sci. 31 35 40 16297627 10.1016/j.tibs.2005.11.001 1:CAS:528: DC%2BD28XosFKkug%3D%3D (Pubitemid 43117541)
4. W.M. Bonner C.E. Redon J.S. Dickey A.J. Nakamura O.A. Sedelnikova S. Solier Y. Pommier 2008 GammaH2AX and cancer Nat. Rev. Cancer 8 957 967 19005492 10.1038/nrc2523 1:CAS:528:DC%2BD1cXhsVWhu7rK
5. C. Chao Z. Wu S.J. Mazur H. Borges M. Rossi T. Lin J.Y. Wang C.W. Anderson E. Appella Y. Xu 2006 Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage Mol. Cell. Biol. 26 6859 6869 16943427 10.1128/MCB.00062-06 1:CAS:528:DC%2BD28Xpt1ClurY%3D (Pubitemid 44387635)
6. A. Ciccia S.J. Elledge 2010 The DNA damage response: making it safe to play with knives Mol. Cell 40 179 204 20965415 10.1016/j.molcel.2010.09.019 1:CAS:528:DC%2BC3cXhtlCjtr7P
7. C. Das M.S. Lucia K.C. Hansen J.K. Tyler 2009 CBP/p300-mediated acetylation of histone H3 on lysine 56 Nature 459 113 117 19270680 10.1038/nature07861 1:CAS:528:DC%2BD1MXivVKnsbc%3D
8. C.E. Dawe M.K. Kooistra N.A. Fairbridge A.C. Pisio H.E. Mc-Dermid 2011 Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development Dev. Dyn. 240 372 383 21246654 10.1002/dvdy.22547 1:CAS:528: DC%2BC3MXislygtb8%3D
9. N.A. Fairbridge C.E. Dawe F.H. Niri M.K. Kooistra K. King-Jones H.E. McDermid 2010 Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors Birth Defects Res. A Clin. Mol. Teratol. 88 619 625 20589882 10.1002/bdra.20695 1:CAS:528:DC%2BC3cXhtVKrsL%2FE
10. T.K. Footz P. Brinkman-Mills G.S. Banting S.A. Maier M.A. Riazi L. Bridgland S. Hu B. Birren S. Minoshima N. Shimizu, et al. 2001 Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere Genome Res. 11 1053 1070 11381032 10.1101/gr.154901 1:CAS:528:DC%2BD3MXkt12ru74%3D (Pubitemid 32834550)
11. Y. Huyen O. Zgheib R.A. Ditullio Jr. V.G. Gorgoulis P. Zacharatos T.J. Petty E.A. Sheston H.S. Mellert E.S. Stavridi T.D. Halazonetis 2004 Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks Nature 432 406 411 15525939 10.1038/nature03114 1:CAS:528:DC%2BD2cXpvVCjtbw%3D (Pubitemid 39551676)
12. S.P. Jackson J. Bartek 2009 The DNA-damage response in human biology and disease Nature 461 1071 1078 19847258 10.1038/nature08467 1:CAS:528: DC%2BD1MXhtlGktLrK
13. H.S. Lee J.H. Park S.J. Kim S.J. Kwon J. Kwon 2010 A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair EMBO J. 29 1434 1445 20224553 10.1038/emboj.2010.27 1:CAS:528:DC%2BC3cXjtFSmur0%3D
14. J. Lukas C. Lukas J. Bartek 2011 More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance Nat. Cell Biol. 13 1161 1169 21968989 10.1038/ncb2344 1:CAS:528:DC%2BC3MXht1GqsL%2FK
15. C. Martin Y. Zhang 2005 The diverse functions of histone lysine methylation Nat. Rev. Mol. Cell Biol. 6 838 849 16261189 10.1038/nrm1761 1:CAS:528:DC%2BD2MXhtFKlsL3N (Pubitemid 41568733)
16. S. Mujtaba L. Zeng M.M. Zhou 2007 Structure and acetyllysine recognition of the bromodomain Oncogene 26 5521 5527 17694091 10.1038/sj.onc.1210618 1:CAS:528:DC%2BD2sXovFersrg%3D (Pubitemid 47255932)
17. J.H. Park E.J. Park H.S. Lee S.J. Kim S.K. Hur A.N. Imbalzano J. Kwon 2006 Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction EMBO J. 25 3986 3997 16932743 10.1038/sj.emboj.7601291 1:CAS:528:DC%2BD28XptFWisLw%3D (Pubitemid 44338741)
18. J.H. Park E.J. Park S.K. Hur S. Kim J. Kwon 2009 Mammalian SWI/SNF chromatin remodeling complexes are required to prevent apoptosis after DNA damage DNA Repair (Amst) 8 29 39 10.1016/j.dnarep.2008.08.011 1:CAS:528:DC%2BD1cXhsVCmsr7J
19. R. Sanchez M.M. Zhou 2009 The role of human bromodomains in chromatin biology and gene transcription Curr. Opin. Drug Discov. Devel. 12 659 665 19736624 1:CAS:528:DC%2BD1MXhsVSltL7K
20. W. Shen C. Xu W. Huang J. Zhang J.E. Carlson X. Tu J. Wu Y. Shi 2007 Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails Biochemistry 46 2100 2110 17274598 10.1021/bi0611208 1:CAS:528:DC%2BD2sXht1Kisbs%3D (Pubitemid 46355321)
21. M. Singh G.M. Popowicz M. Krajewski T.A. Holak 2007 Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex Chembiochem 8 1308 1316 17582821 10.1002/cbic.200600562 1:CAS:528:DC%2BD2sXos12rtr8%3D (Pubitemid 47171998)
22. S.D. Taverna H. Li A.J. Ruthenburg C.D. Allis D.J. Patel 2007 How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers Nat. Struct. Mol. Biol. 14 1025 1040 17984965 10.1038/nsmb1338 1:CAS:528:DC%2BD2sXht1Kjs7vE (Pubitemid 350060344)
23. P.J. Thompson K.A. Norton F.H. Niri C.E. Dawe H.E. McDermid 2012 CECR2 is involved in spermatogenesis and forms a complex with SNF2H in the testis J. Mol. Biol. 415 793 806 22154806 10.1016/j.jmb.2011.11.041 1:CAS:528: DC%2BC38XhsFShu7Y%3D
24. J.V. Tjeertes K.M. Miller S.P. Jackson 2009 Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells EMBO J. 28 1878 1889 19407812 10.1038/emboj.2009.119 1:CAS:528:DC%2BD1MXlt1Gmtbc%3D
25. H. van Attikum S.M. Gasser 2009 Crosstalk between histone modifications during the DNA damage response Trends Cell Biol. 19 207 217 19342239 10.1016/j.tcb.2009.03.001
26. Q. Zhang S. Chakravarty D. Ghersi L. Zeng A.N. Plotnikov R. Sanchez M.M. Zhou 2010 Biochemical profiling of histone binding selectivity of the yeast bromodomain family PLoS One 5 e8903 20126658 10.1371/journal.pone.0008903