Ultrasensitive nanostructured immunosensor for stem and carcinoma cell pluripotency gatekeeper protein NANOG

Nanomedicine

Volumn 7, Issue 7, 2012, Pages 957-965

  Chikkaveeraiah, Bhaskara V ^a   Soldà, Alice ^a,b   Choudhary, Dharamainder ^a,c   Maran, Flavio ^b   Rusling, James F ^a,c  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

cancer biomarker; electrochemical immunosensor; gold nanoparticle; magnetic particle; NANOG; pluripotency; stem cell

Indexed keywords

GOLD NANOPARTICLE; GRAPHITE; MESSENGER RNA; NANOMATERIAL; TRANSCRIPTION FACTOR NANOG;

ARTICLE; CARCINOMA CELL; CELL LYSATE; CONTROLLED STUDY; ELECTROCHEMISTRY; EMBRYONIC STEM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOSENSOR; NANOFABRICATION; PLURIPOTENT STEM CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUALITATIVE ANALYSIS; SENSITIVITY ANALYSIS; WESTERN BLOTTING;

ANTIBODIES, IMMOBILIZED; BIOSENSING TECHNIQUES; CELL LINE; ELECTROCHEMICAL TECHNIQUES; EMBRYONIC STEM CELLS; GOLD; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOASSAY; LIMIT OF DETECTION; METAL NANOPARTICLES;

EID: 84864465422     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.11.178     Document Type: Article

References (41)

1. Wulfkuhle JD, Liotta LA, Petricoin EF. Proteomic applications for the early detection of cancer. Nat. Rev. Cancer 3, 267-275 (2003). (Pubitemid 37328862)
2. Rusling JF, Kumar CV, Gutkind JS, Patel V. Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. Analyst 135, 2496-2511 (2010).
3. Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer 5, 161-171 (2005). (Pubitemid 40314948)
4. Wang J. Electrochemical biosensors: towards point-of-care cancer diagnostics. Biosens. Bioelectron. 21, 1887-1892 (2006).
5. Kingsmore SF. Multiplexed protein measurement: technologies and applications of protein and antibody arrays. Nat. Rev. Drug Discov. 5, 310-321 (2006).
6. Giljohann DA, Mirkin CA. Drivers of biodiagnostic development. Nature 462, 461-464 (2009).
7. Tothill IE. Biosensors for cancer markers diagnosis. Semin. Cell Dev. Biol. 20, 55-62 (2009).
8. Mitsui K, Tokuzawa Y, Itoh H et al. The homeoprotein NANOG is required for maintainance of pluripotency in mouse epiblast and ES cells. Cell 113, 631-642 (2003). (Pubitemid 36694188)
9. Chambers I, Colby D, Robertson M et al. Functional expression cloning of NANOG, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643-655 (2003). (Pubitemid 36694189)
10. Hyslop L, Stojkovic M, Armstrong L et al. Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. Stem Cells 23, 1035-1043 (2005). (Pubitemid 41377718)
11. Zhang X, Stojkovic P, Przyborski S et al. Derivation of human embryonic stem cells from developing and arrested embryos. Stem Cells 24, 2669-2676 (2006). (Pubitemid 46070118)
12. Hoei-Hansen CE, Almstrup K, Nielsen JE et al. Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. Histopathology 47, 48-56 (2005). (Pubitemid 40978813)
13. Hart AH, Hartley L, Parker K et al. The pluripotency homeobox gene NANOG is expressed in human germ cell tumors. Cancer 104, 2092-2098 (2005). (Pubitemid 41579954)
14. Ezeh UI, Turek PJ, Reijo RA, Clark AT. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 104, 2255-2265 (2005). (Pubitemid 41579973)
15. Hart AH, Hartley L, Ibrahim M, Robb L. Identifcation, cloning and expression analysis of the pluripotency promoting NANOG genes in mouse and human. Develop. Dynamics 230, 187-198 (2004). (Pubitemid 38544086)
16. Clark AT, Rodriguez RT, Bodnar MS et al. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. Stem Cells 22, 169-179 (2004). (Pubitemid 38282632)
17. Kuijk EW, de Gier J, Lopes SMC et al. A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis. PLoS One 5, e10987 (2010).
18. Kim JS, Kim J, Kim BS et al. Identifcation and functional characterization of an alternative splice variant within the fourth exon of human NANOG. Exp. Mol. Med. 37, 601-607 (2005). (Pubitemid 43143522)
19. Beltrami AP, Cesselli D, Bergamin N et al. Multipotent cells can be generated in vitro from several adult human organs (heart, liver, and bone marrow). Blood 110, 3438-3446 (2007). (Pubitemid 350106340)
20. Cesselli D, Beltrami A P, Rigo S et al. Multipotent progenitor cells are present in human peripheral blood. Circ. Res. 104, 1225-1234 (2009).
21. Stahlberg A, Bengtsson M, Hemberg M, Semb H. Quantitative transcription factor analysis of undifferentiated single human embryonic stem cells. Clin. Chem. 55, 2162-2170 (2009).
22. Eberle I, Pless B, Braun M, Dingermann T, Marschalek R. Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells. Nucleic Acids Res. 38, 5384-5395 (2010).
23. Jeter CR, Badeaux M, Choy G et al. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells 27, 993-1005 (2009).
24. ® Chemistry for the Detection and Relative Quantifcation of Protein Markers in Embryonic Stem Cells. 2010 Life Technologies Corporation, CA, USA (2010).
25. Malhotra R, Papadimitrakopoulos F, Rusling JF. Sequential layer analysis of protein immunosensors based on single wall carbon nanotube forests. Langmuir 26, 15050-15056 (2010).
26. Yu X, Munge B, Patel V et al. Carbon nanotube amplifcation strategies for highly sensitive immunodetection of cancer biomarkers. J. Am. Chem. Soc. 128, 11199-11205 (2006). (Pubitemid 44300129)
27. Mani V, Chikkaveeraiah BV, Patel V, Gutkind JS, Rusling JF. Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticles flm electrodes and multienzyme-particle amplifcation. ACS Nano 3, 585-594 (2009).
28. Malhotra R, Patel V, Vaque JP, Gutkind JS, Rusling JF. Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplifcation. Anal. Chem. 82, 3118-3123 (2010).
29. Munge BS, Krause CE, Malhotra R, Patel V, Gutkind JS, Rusling JF. Electrochemical immunosensors for interleukin-6. Comparison of carbon nanotube forest and gold nanoparticle platforms. Electrochem. Comm. 11, 1009-1012 (2009).
30. Chikkaveeraiah BV, Bhirde A, Malhotra R, Patel V, Gutkind JS, Rusling JF. Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer. Anal. Chem. 81, 9129-9134 (2009).
31. Soelberg SD, Stevens RC, Limaye AP, Furlong CE. Surface plasmon resonance detection using antibody-linked magnetic nanoparticles for analyte capture, purifcation, concentration and signal amplifcation. Anal. Chem. 81, 2357-2363 (2009).
32. Gao L, Zhuang J, Nie L et al. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat. Nanotech. 2, 577-583 (2007). (Pubitemid 47367542)
33. Krishnan S, Mani V, Wasalathanthri D, Kumar CV, Rusling JF. Attomolar detection of a cancer biomarker protein in serum by surface plasmon resonance using superparamagnetic particle labels. Angew. Chem. Int. Ed. 122, 1-5 (2010).
34. Chikkaveeraiah BV, Mani V, Patel V, Gutkind JS, Rusling JF. Microfuidic electrochemical immunoarray for ultrasensitive deteciton of two cancer biomarker proteins in serum. Biosens. Bioelectron. 26, 4477-4483 (2011).
35. Munge BS, Coffey AL, Doucette JM et al. Nanostuctured immunosensor for attomolar detection of cancer biomarker interleukin-8 using massively labeled superparamgentic particles. Angew. Chem. Int. Ed. 50, 7915-1918 (2011).
36. Pütter J. Methods of Enzymatic Analysis. Becker R, Bergmeyer HU (Eds). Verlag Chemie, FL, USA, 286-293 (1983).
37. Rusling JF. Electroactive and enzyme-active protein-polyion flms assembled layer by layer. In: Protein Architecture: Interfacing Molecular Assemblies and Immobilization Biotechnology. Lvov Y, Mohwald H (Eds). Marcel Dekker, NY, USA, 337-354 (2000).
38. Lvov YM. Thin flm nanofabrication by alternate adsorption of polyions, nanoparticles, and proteins. In: Handbook of Surfaces and Interfaces of Material: Nanostructured Materials, Micelles, and Colloids. Nalwa HS (Ed.). Academic Press, CA, USA, 170-187 (2001).
39. Bard AJ, Faulkner, LR. Electrochemical Methodsm (2nd Edition). John Wiley & Sons, NY, USA, 231 (2001).
40. Vugler A, Carr AJ, Lawrence J et al. Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation. Exp. Neurol. 214, 347-361 (2008).
41. Buchholz DE, Hikita ST, Rowland TJ et al. Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells. Stem Cells 27, 2427-2434 (2009).