Sauchinone suppresses lipopolysaccharide-induced inflammatory responses through Akt signaling in BV2 cells

International Immunopharmacology

Volumn 14, Issue 2, 2012, Pages 188-194

  Jang, Eun Young ^a   Yang, Chae Ha ^a   Han, Min Ho ^b   Choi, Yung Hyun ^b   Hwang, Meeyul ^a  

^a Daegu Haany University   (South Korea)

^b Dong Eui University   (South Korea)

Author keywords

Akt; Inflammation; Microglia; NF B; Sauchinone

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; POLYPHENOL DERIVATIVE; PROSTAGLANDIN E2; PROTEIN KINASE B; SAUCHINONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATION; MICROGLIA; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BENZOPYRANS; CELL LINE; DINOPROSTONE; DIOXOLES; HUMANS; IMMUNOSUPPRESSION; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NEURODEGENERATIVE DISEASES; NF-KAPPA B; NITRIC OXIDE; ONCOGENE PROTEIN V-AKT; SIGNAL TRANSDUCTION;

EID: 84864453968     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.07.002     Document Type: Article

References (25)

1. Y. Itzhak, J.L. Martin, and S.F. Ali Comparison between the role of the neuronal and inducible nitric oxide synthase in methamphetamine-induced neurotoxicity and sensitization Ann N Y Acad Sci 914 2000 104 111
2. Ph. Wu, Y.C. Shen, Y.H. Wang, C.W. Chi, and J.C. Yen Baicalein attenuates methamphetamine-induced loss of dopamine transporter in mouse striatum Toxicology 226 2006 238 245 (Pubitemid 44287163)
3. J. Zielasek, and H.P. Hartung Molecular mechanisms of microglial activation Adv Neuroimmunol 6 1996 191-222 (Pubitemid 26279977)
4. L. Meda, M.A. Cassetella, G.I. Szendrei, L. Otvos Jr., P. Baron, and M. Villalba Activation of microglial cells by b-amyloid protein and interferon-g Nature 373 2006 647 650
5. P. Dandona, H. Ghanim, A. Chaudhuri, and S.S. Kim Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance Exp Mol Med 42 2010 245 253
6. F. Gonzalez-Scarano, and G. Baltuch Microglia as mediators of inflammatory and degenerative diseases Annu Rev Neurosci 22 1999 219 240 (Pubitemid 29144887)
7. T. Kita, Y. Matsunari, T. Saraya, K. Shimada, K. O'Hara, and K. Kubo Methamphetamine-induced striatal dopamine release, behavior changes and neurotoxicity in BALB/c mice Int Dev Neurosci 18 2000 521 530 (Pubitemid 30406993)
8. G. Flora, Y.W. Lee, A. Nath, W. Maragos, B. Henning, and M. Toborek Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid peroxidation Neuromolecular Med 2 2002 71 85 (Pubitemid 37012511)
9. B. Liu, and J.S. Hong Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention J Pharmacol Exper Ther 304 2003 1 7 (Pubitemid 36008905)
10. P. Eikelenboom, and W.A. van Gool Neuroinflammatory perspectives on the two faces of Alzheimer's disease J Neural Transm 111 2004 281 294 (Pubitemid 38316606)
11. P. Moreillon, and P.A. Majcherczyk Proinflammatory activity of cell-wall constituents from gram-positive bacteria Scand J Infect Dis 35 2003 632 641 (Pubitemid 37336885)
12. J.C. Marshall Lipopolysaccharide: an endotoxin or an exogenous hormone? Clin Infect Dis 41 2005 S470 S480
13. E.C. Wang, M.H. Shih, M.C. Liu, M.T. Chen, and G.H. Lee Studies on constituents of Saururus chinensis Heterocycles 43 1996 969 975
14. S.H. Sung, and Y.C. Kim Hepatoprotective diastereomeric lignans from Saururus chinensis herbs J Nat Prod 3 2000 1019 1021 (Pubitemid 30624498)
15. S.H. Sung, E.J. Lee, J.H. Cho, H.S. Kim, and Y.C. Kim Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes Biol Pharm Bull 23 2000 666 668 (Pubitemid 30321295)
16. A.K. Lee, S.H. Sung, Y.C. Kim, and S.G. Kim Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-α and COX-2 expression by sauchinone effects on I-phosphorylation, C/EBP and AP-1 activation Br J Pharmacol 139 2003 11 20 (Pubitemid 36645303)
17. H.B. Bae, M. Li, J.K. Son, C.S. Seo, S.H. Chung, and S.J. Kim Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation Int Immunopharmacol 10 2010 1022 1028
18. M. Guha, and N. Mackman LPS induction of gene expression in human monocytes Cell Signal 13 2001 85 94 (Pubitemid 32222977)
19. B.B. Aggarwal, and S. Shishodia Molecular targets of dietary agents for prevention and therapy of cancer Biochem Pharmacol 71 2006 1397 1421
20. V. Dixit, and T.W. Mak NF-kappa B signaling. Many roads lead to Madrid Cell 111 2002 615 619 (Pubitemid 35441244)
21. C.S. Lee, C. Won, H. Yoo, E.H. Yi, Y. Cho, and J.W. Maeng Inhibition of double-stranded RNA-induced inducible nitric oxide synthase expression by fraxinellone and sauchinone in murine microglia Biol Pharm Bull 32 2009 1870 1874
22. S. Akira, and K. Taketa Toll-like receptor signaling Nat Rev Immunol 4 2010 499 511
23. M. Ojaniemi, V. Glumoff, K. Harju, M. Liljeroos, and K. Vuori Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages Eur J Immunol 33 2003 597 605 (Pubitemid 36367663)
24. L.V. Madrid, C.Y. Wang, D.C. Guttridge, A.J. Schottelius, A.S. Baldwin Jr., and M.W. Mayo Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kB Mol Cell Biol 20 2000 1626 1638 (Pubitemid 30100182)
25. J.Y. Lee, B.S. Jhun, Y.T. Oh, J.H. Lee, and W. Choe Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells Neurosci Lett 396 2006 1 6 (Pubitemid 43233777)