Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-α production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation

International Immunopharmacology

Volumn 10, Issue 9, 2010, Pages 1022-1028

  Bae, Hong Beom ^a   Li, Mei ^a,b   Son, Jong Keun ^c   Seo, Chang Seob ^c,d   Chung, Seung Hyun ^a   Kim, Seok Jai ^a   Jeong, Cheol Won ^a   Lee, Hyung Gon ^a   Kim, Woongmo ^a   Park, Hwan Chul ^a   Kwak, Sang Hyun ^a  

^a Chonnam National University Medical School   (South Korea)

^b ZHEJIANG UNIVERSITY   (China)

^c Yeungnam University   (South Korea)

^d Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Cytokines; LPS; Mitogen activated protein kinases; Nuclear factor B; Sauchinone

Indexed keywords

LIGNAN DERIVATIVE; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; RAF PROTEIN; SAUCHINONE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVATION; MACROPHAGE ACTIVATION; MEDICINAL PLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SAURURUS CHINENSIS; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOPYRANS; CHEMOKINE CXCL2; DIOXOLES; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-RAF; SAURURACEAE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955918239     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.06.001     Document Type: Article

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