Extraction, purification and antitumor activity of a water-soluble polysaccharide from the roots of Polygala tenuifolia

Carbohydrate Polymers

Volumn 90, Issue 2, 2012, Pages 1127-1131

  Xin, Tao ^a   Zhang, Fubin ^a   Jiang, Qiuying ^a   Chen, Chunhong ^a   Huang, Dayong ^a   Li, Yanju ^a   Shen, Weixi ^a   Jin, Yinghua ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Antitumor; Human ovarian cancer; Polygala tenuifolia; Polysaccharide; Purification

Indexed keywords

ANTI-TUMOR ACTIVITIES; ANTI-TUMORS; ANTICANCER ACTIVITIES; CONCENTRATION-DEPENDENT; GLUTATHIONES; IN-VITRO; NUDE MICE; OVARIAN CANCER CELLS; OVARIAN CANCERS; POLYGALA TENUIFOLIA; REACTIVE OXYGEN SPECIES; TUMOR GROWTH; WATER-SOLUBLE POLYSACCHARIDES;

AMINO ACIDS; CELL DEATH; GLUCOSE; POLYSACCHARIDES; PURIFICATION;

DISEASES;

ANTINEOPLASTIC AGENT; HERBACEOUS AGENT; POLYSACCHARIDE; WATER;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CARCINOMA; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; FEMALE; HUMAN; ISOLATION AND PURIFICATION; MOUSE; NUDE MOUSE; OVARY TUMOR; PATHOLOGY; PLANT ROOT; POLYGALA; SOLUBILITY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA; CELL LINE, TUMOR; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; OVARIAN NEOPLASMS; PLANT ROOTS; POLYGALA; POLYSACCHARIDES; SOLUBILITY; WATER; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS MUSCULUS; POLYGALA TENUIFOLIA; RATTUS;

EID: 84864448621     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2012.06.058     Document Type: Article

References (29)

1. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein binding Analytical Biochemistry 72 1976 248 254
2. W. Cao, X.Q. Li, X. Wang, T. Li, X. Chen, and S.B. Liu Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels International Journal of Biological Macromolecules 46 2010 115 122
3. M. Dubois, K.A. Gilles, J.K. Hamilton, P.A. Rebers, and F. Smith Colorimetric method for determination of sugars and related substances Analytical Chemistry 28 1956 350 356
4. J.J. Chen, T. Zhang, B. Jiang, W.M. Mu, and M. Miao Characterization and antioxidant activity of Ginkgo biloba exocarp polysaccharides Carbohydrate Polymers 87 2012 40 45
5. Y. Chen, M.Y. Xie, S.P. Nie, C. Li, and Y.X. Wang Purification, composition analysis and antioxidant activity of a polysaccharide from the fruiting bodies of Ganoderma atrum Food Chemistry 107 2008 231 241 (Pubitemid 47633852)
6. M.C. Cheng, C.Y. Li, H.C. Ko, F.N. Ko, Y.L. Lin, and T.S. Wu Antidepressant principles of the roots of Polygala tenuifolia Journal of Natural Products 69 2006 1305 1309
7. I.W. Chung, S.R. Kim, and E.G. Kim Dopamine-2 and serotonine-2 receptor bindings in antipsychotic medicines from natural products Journal of Korean Neuropsychiatric Association 31 1992 856 867
8. I.W. Chung, N.A. Moore, W.K. Oh, M.F. O'Neill, J.S. Ahn, and J.B. Park Behavioural pharmacology of polygalasaponins indicates potential antipsychotic efficacy Pharmacology, Biochemistry and Behavior 71 2002 191 195 (Pubitemid 34102478)
9. T.M.C.C. Filisetti-Cozzi, and N.C. Carpita Measurement of uronic acids without interference from neutral sugars Analytical Biochemistry 197 1991 157 162
10. Y. Gao, H. Gao, E. Chan, W. Tang, A. Xu, and H. Yang Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice Immunological Investigations 34 2005 171 198 (Pubitemid 40677457)
11. T.J. Hsieh, T.Z. Liu, F.J. Lu, P.Y. Hsieh, and C.H. Chen Actinodaphnine induces apoptosis through increased nitric oxide, reactive oxygen species and down-regulation of NF-κB signaling in human hepatoma Mahlavu cells Food and Chemical Toxicology 44 2006 344 354
12. K.J. Jang, K.H. Lee, S.L. Kim, D.Y. Choi, B.K. Park, and D.H. Im Chongmyungtang attenuates kainic acid-induced seizure and mortal effect in the mouse Archives of Pharmacal Research 20 1997 375 378
13. H.M. Kim, E.H. Lee, H.J. Na, S.B. Lee, T.Y. Shin, and Y.S. Lyu Effects of Polygala tenuifolia root extract on the tumor necrosis factor-1 secretion from mouse astrocytes Journal of Ethnopharmacology 61 1998 201 208 (Pubitemid 28342687)
14. Y.L. Lin, W.P. Chen, H.C. Ko, F.N. Ko, and T.S. Wu Norepinephrine transporter inhibitors from Polygala tenuifolia Journal of Food and Drug Analysis 16 2008 26 30
15. J. Liu, X. Yang, J. He, M. Xia, L. Xu, and S. Yang Structure analysis of triterpene saponins in Polygala tenuifolia by electrospray ionization ion trap multiple-stage mass spectrometry Journal of Mass Spectrometry 42 2007 861 873 (Pubitemid 47057068)
16. Y. Liu, Y. Li, W. Yang, L. Zhang, and G. Cao Anti-hepatoma activity in mice of a polysaccharide from the rhizome of Anemone raddeana International Journal of Biological Macromolecules 50 2012 632 636
17. A. Macho, T. Hirsch, I. Marzo, P. Marchetti, B. Dallaporta, and S.A. Susin Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis Journal of Immunology 158 1997 4612 4619 (Pubitemid 127483779)
18. J.M. Matés, and F.M. Sánchez-Jiménez Role of reactive oxygen species in apoptosis: Implications for cancer therapy The International Journal of Biochemistry and Cell Biology 32 2000 157 170 (Pubitemid 30001819)
19. M. Mizuno, Y. Shiomi, K. Minato, S. Kawakami, H. Ashida, and H. Tsuchida Fucogalactan isolated from Sarcodon aspratus elicits release of tumor necrosis factor-α and nitric oxide from murine macrophages Immunopharmacology 46 2000 113 121 (Pubitemid 30019253)
20. W. Ni, X. Zhang, B. Wang, Y. Chen, H. Han, and Y. Fan Antitumor activities and immunomodulatory effects of Ginseng neutral polysaccharides in combination with 5-fluorouracil Journal of Medicinal Food 13 2010 270 277
21. M.H. Pan, Y.T. Huang, C.T. Ho, C.I. Chang, P.C. Hsu, and P.B. Sun Induction of apoptosis by Meretrix lusoria through reactive oxygen species production, glutathione depletion, and caspase activation in human leukemia cells Life Sciences 79 2006 1140 1152
22. C.H. Park, S.H. Choi, J.W. Koo, J.H. Seo, H.S. Kim, and S.J. Jeong Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11 Journal of Neuroscience Research 70 2002 484 492 (Pubitemid 35222385)
23. T.F. Slater, B. Sawyer, and U. Straeuli Studies on succinate tetrazolium reductase systems III. Points of coupling of four different tetrazolium salts Biochimica et Biophysica Acta 77 1963 383 393
24. H. Wang, and J.A. Joseph Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader Free Radical Biology and Medicine 27 1999 612 616 (Pubitemid 29408648)
25. J. Wang, G. Zuo, J. Li, T. Guan, C. Li, and R. Jiang Induction of tumoricidal activity in mouse peritoneal macrophages by ginseng polysaccharide International Journal of Biological Macromolecules 46 2010 389 395
26. L. Wang, H. Huang, Y. Wei, X. Li, and Z. Chen Characterization and anti-tumor activities of sulfated polysaccharide SRBPS2a obtained from defatted rice bran International Journal of Biological Macromolecules 45 2009 427 431
27. X. Wang, S. Yuan, J. Wang, P. Lin, G. Liu, and Y. Lu Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo Toxicology and Applied Pharmacology 215 2006 168 178 (Pubitemid 44190001)
28. H. Zhang, T. Han, L. Zhang, C.H. Yu, D.G. Wan, and K. Rahmanc Effects of tenuifolin extracted from radix polygalae on learning and memory: A behavioral and biochemical study on aged and amnesic mice Phytomedicine 15 2008 587 594
29. L.B. Zhou, and B. Chen Bioactivities of water-soluble polysaccharides from Jisongrong mushroom: Anti-breast carcinoma cell and antioxidant potential International Journal of Biological Macromolecules 48 2011 1 4