Norepinephrine transporter inhibitors from Polygala tenuifolia

Journal of Food and Drug Analysis

Volumn 16, Issue 3, 2008, Pages 26-30

  Lin, Yun Lian ^a   Chen, Wan Ping ^a   Ko, Han Chieh ^a   Ko, Feng Nien ^b   Wu, Tian Shung ^c  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b Taiwan Army   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Norepinephrine transporter inhibitor; Phenolic glycosides; Polygala tenuifolia; Saponins; Xanthone glycosides

Indexed keywords

3 O BETA DEXTRO GLUCOPYRANOSYL PRESENEGENIN 28 [O BETA DEXTRO GALATOPYRANOSYL(1-4) BETA DEXTRO XYLOPYRANOSYL (1-4) ALPHA LEVO RHAMNOPYRANOSYL(1-2) BETA DEXTRO FUCOPYRANOSYL] ESTER; 3',6 DISINAPOYLSUCROSE; 7 O METHYLMANGIFERIN; ADENOSINE; DESIPRAMINE; GLYCOSIDE; METHYLSINAPOATE; NEOLANCERIN; NORADRENALIN TRANSPORTER; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POLYGALA TENUIFOLIA EXTRACT; POLYGALASAPONIN XXVIII; POLYGALAXANTHONE III; POLYGALAXANTHONE IX; SIBIRICAXANTHONE B; SIBIRICOSES A3; SIBIRICOSES A5; SIBIRICOSES A6; TENUIFOLIN; TENUIFOLISIDE A; TRITERPENOID;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DOG; DRUG PROTEIN BINDING; DRUG STRUCTURE; FRACTIONATION; INFRARED SPECTROSCOPY; ISOLATION AND PURIFICATION; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOT; POLYGALA TENUIFOLIA; POLYGALACEAE;

POLYGALA TENUIFOLIA;

EID: 50449103268     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Jiangshu New Medical College. 1997. Dictionary of Chinese Drugs. p. 2174. Shanghai Scientific Technologic Publisher. Shanghai, China.
2. Sakuma, S. and Shoji, J. 1981. Studies on the constituents of the root of Polygala tenuifolia Willd. I. Isolation of saponins and the structures of onjisaponins G and F. Chem. Pharm. Bull. 29: 2431-2441.
3. Sakuma, S. and Shoji, J. 1982. Studies on the constituents of the root of Polygala tenuifolia Willd. I. Isolation of saponins and the structures of onjisaponins A, B and E. Chem. Pharm. Bull. 30: 810-821.
4. Ikeya, Y., Sugama, K., Okada, M. and Mitsuhashi, H. 1991. Two xanthones from Polygala tenuifolia. Phytochemistry 30: 2061-2065.
5. Fujita, T., Liu, D. Y., Ueda, S. and Takeda, Y. 1992. Xanthones from Polygala tenuifolia. Phytochemistry 31: 3997-4000.
6. Ikeya, Y., Sugama, K. and Maruno, M. 1994. Xanthone C-glycoside and acylated sugar from Polygala tenuifolia. Chem. Pharm. Bull. 42: 2305-2308.
7. Jiang, Y. and Tu, P. F. 2002. Xanthone O-glycosides from Polygala tenuifolia. Phytochemistry 60: 813-816.
8. Jiang, Y., Zhang, W., Tu, P. and Xu, X. 2005. Xathone Glycosides from Polygala tenuifolia and their conformational analyses. J. Nat. Prod. 68: 875-879.
9. Jiang, Y. and Tu, P. F., 2005. Four new phenones from the cortexes of Polygala tenuifolia. Chem. Pharm. Bull. 53: 1164-1166.
10. Ikeya, Y., Sugama, K., Okada, M. and Mitsuhashi, H. 1991. Four new phenolic glycosides from Polygala tenuifolia. Chem. Pharm. Bull. 39: 2600-2605.
11. Miyase, T., Iwata, Y. and Ueno, A. 1991. Tenuifoliosides A-F, oligosaccharide multi-esters from roots of Polygala tenuifolia Willd. Chem. Pharm. Bull. 39: 3082-3084.
12. Miyase, T., Iwata, Y. and Ueno, A. 1992. Tenuifolioses G-P, oligosaccharide multi-esters from the roots of Polygala tenuifolia Willd. Chem. Pharm. Bull. 40: 2741-2748.
13. Miyase, T. and Ueno, A. 1993. Sucrose derivatives from the roots of Polygala tenuifolia. Shoyakugaku Zasshi 47: 267-278.
14. Saitoh, H., Miyase, T. and Ueno, A. 1994. Reinioses A-J, oligosaccharide multi-esters from the roots of Polygala tenuifolia. Chem. Pharm. Bull. 42: 1879-1885.
15. Cheng, M. C., Li, C. Y., Ko, H. C., Ko, F. N., Lin, Y. L. and Wu, T. S. 2006. Antidepressant principles of the roots of Polygala tenuifolia. J. Nat. Prod. 69: 1305-1309.
16. Park, J. H., Kim, J. S., Jang, D. S. and Lee, S. M. 2006. Effect of Polygala tenuifolia root extract on cerebral ischemia and reperfusion. Am. J. Chin. Med. 34: 115-123.
17. Lee, H. J., Ban, J. Y., Koh, S. B., Seong, N. S., Song, K. S., Bae, K. W. and Seong, Y. H. 2004. Polygalae radix extract protects cultured rat granule cells against damage induced by NMDA. Am. J. Chin. Med. 32: 599-610.
18. Jia, H., Jiang, Y., Ruan, Y., Zhang, Y., Ma, X., Zhang, J., Beyreuther, K., Tu, P. and Zhang, D. 2004. Tenuigenin treated decreased secretion of the Alzheimer's disease amyloid β-protein in cultured cells. Neurosci. Lett. 367: 123-128.
19. Shin, E. J., Oh, K. W., Kim, K. W., Kwon, Y. S., Jhoo, J. H., Jhoo, W. K., Cha, J. Y., Lim, Y. K., Kim, I. S. and Kim, H. C. 2004. Attenuation of cocaine-induced conditioned place preference by Polygala tenuifolia. Life Sci. 75: 2751-2764.
20. Chen, Y. L., Hsieh, C. L., Wu, P. H. and Lin, J. G.. 2004. Effect of Polygala tenuifolia root on behavioral disorders by lesioning nucleus basalis magnocellularis in rat. J. Ethnopharmacol. 95: 47-55.
21. Ikeya, Y., Takeda, S., Tunakawa, M., Karakida, H., Toda, K. and Yamaguchi, T. 2004. Cognitive improving and cerebral protective effects of acylated oligosacharides in Polygala tenuifolia. Biol. Pharm. Bull. 27: 1081-1085.
22. Kawashima, K., Miyako, D., Ishino, Y., Makino, T., Saito, K. and Kano, Y. 2004. Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia. Biol. Pharm. Bull. 27: 1317-1319.
23. Chung, I. W., Moore, N. A., Oh, W. K., O'Neill, M. F., Ahn, J. S., Park, J. B., Kang, U. G., and Kim, Y. S. 2002. Behavioural pharmacology of polygasaponins indicates potential antipsychotic efficacy. Pharmacol. Biochem. Behav. 71: 191-195.
24. Park, C. H., Choi, S. H., Seo, J. H., Koo, J. W., Seo, H. S., Kim, H. S., Jeong, S. J. and Suh, Y. H. 2002. Novel cognitive improving and neuroprotective activities of Polygala tenuifolia Willdenow extract, BT-11. J. Neurosci. Res. 70: 484-492.
25. Zhang, D., Miyase, T., Kuroyanagi, M., Umehara, K. and Ueno, A. 1996. Five new triterpene saponins, polygalasaponins XXVIII-XXXII from the root of Polygala japonica. Chem. Pharm. Bull. 44: 810-815.
26. Mitaine-Offer, A. C., Miyamoto, T., Jolly, C., Delaude, C. and Lacaille-Dubois, M. A. 2005. Triterpene saponins from species of the Polygalaceae family. Helv. Chim. Acta. 88: 2986-2994.
27. Galli, A., DeFelice, L. J., Duke, B. J., Moore, K. R. and Blakely, R. D. 1995. Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected Hek-293 cells blocked by cocaine and antidepressants. J. Exp. Biol. 198: 2197-2212.
28. Schaufelberger, D. and Hostettmann, K. 1988. Chemistry and Pharmacology of Gentiana lacteal. Planta Med. 54: 219-221.
29. Miyase, T., Noguchi, H. and Chen X. M. 1999. Sucrose esters and xanthone C-glycosides from the roots of Polygala sibirica. J. Nat. Prod. 62: 993-996.
30. Aritomi M. and Kawasaki, T. 1970. A mangiferin monomethyl ether from Mangifera indica L. Chem. Pharm. Bull. 18: 2224-2234.
31. Cambie, R. C., Lal, A. R., Rickard, C. E. F. and Tanaka, N. 1990. Chemistry of Fujian plants. V. Constituents of Fagraea gracilipes A. Gray. Chem. Pharm. Bull. 38: 1857-1861.
32. Lin, Y. L., Wang, W. Y., Kuo, Y. H. and Chen, C. F. 2000. Nonsteroidal constituents from Solanum incanum L. J. Chin. Chem. Soc. 47: 247-251.
33. 13C NMR study of α- and β-anomeric pairs of D-mannopyranosides and L-rhamnopyranosides. Tetrahedron 35: 1427-1432.