SCOPUS 정보 검색 플랫폼

Volumn 20, Issue 16, 2012, Pages 5033-5041

Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group

(10) Yoshida, Tomohiro a Akahoshi, Fumihiko a Sakashita, Hiroshi a,c Sonda, Shuji a Takeuchi, Masahiro a Tanaka, Yoshihito a Nabeno, Mika a Kishida, Hiroyuki b Miyaguchi, Ikuko b Hayashi, Yoshiharu a,b

a MITSUBISHI TANABE PHARMA CORPORATION (Japan)

b MITSUBISHI CHEMICAL CORPORATION (Japan)

c Tanabe RandD Service Corporation (Japan)

Author keywords

Bicyclic heteroarylpiperazine; DPP 4 inhibitor; Thiazolidine

Indexed keywords

2 CHLOROBENZIMIDAZOLE 5 CARBONITRILE; 3 (1 TERT BUTOXYCARBONYL 4 OXOPYRROLIDIN 2 YLCARBONYL)THIAZOLIDINE; 3 [1 BENZYLOXYCARBONYL 4 (PIPERAZIN 1 YL)PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (2 METHYLQUINOLIN 4 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (2 TRIFLUOROMETHYLQUINOLIN 4 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (4 CHLOROISOQUINOLIN 1 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (4 CYANOISOQUINOLIN 1 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (5 CHLOROBENZIMIDAZOL 2 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (5 CYANOBENZIMIDAZOL 2 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (5 CYANOBENZOTHIAZOL 2 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (5 CYANOBENZOXAZOL 2 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (7 CHLOROLQUINOLIN 4 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (7 TRIFLUOROMETHYLQUINOLIN 4 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (BENZIMIDAZOL 2 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (BENZOTHIAZOL 2 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (BENZOXAZOL 2 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (ISOQUINOLIN 1 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (QUINOLIN 2 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; 3 [4 [4 (QUINOLIN 4 YL)PIPERAZIN 1 YL]PYRROLIDIN 2 YLCARBONYL]THIAZOLIDINE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; NITRILE; PROLYLTHIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHILICITY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IC 50; IN VITRO STUDY; MALE; NONHUMAN; RAT;

ANIMALS; BICYCLO COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRILES; PIPERAZINES; PROLINE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 84864436192 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.06.033 Document Type: Article

Times cited : (37)

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