[(S)-γ-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3662-3671

  Sakashita, Hiroshi ^a   Akahoshi, Fumihiko ^a   Kitajima, Hiroshi ^a   Tsutsumiuchi, Reiko ^b   Hayashi, Yoshiharu ^c  

^a Research and Development Division   (Japan)

^b Technology and Production Division   (Japan)

^c MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

DPP IV inhibitor; Thiazolidine

Indexed keywords

3 (4 ANILINO 2 PYRROLIDINYLCARBONYL) 1,3 THIAZOLIDINE; 3 [4 (2 CHLORO 4 CYANOPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (2 CYANOPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (3 CHLORO 4 CYANOPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (3 CHLORO 4 METHOXYPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (3,4 DICYANOPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (3,4 METHYLENEDIOXYPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (4 AMINOPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (4 ANISIDINO) 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (4 CHLOROPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (4 CYANOPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (4 METHANESULFONYLPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (4 NITROPHENYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; 3 [4 (5 CYANO 2 PYRIDYL)AMINO 2 PYRROLIDINYLCARBONYL] 1,3 THIAZOLIDINE; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; NITRILE; THIAZOLE DERIVATIVE; THIAZOLIDIDE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; HUMAN; HYDROPHOBICITY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD26; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MOLECULAR CONFORMATION; NITRILES; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 33646033123     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.022     Document Type: Article

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