Enhancing pedicle screw fixation in the aging spine with a novel bioactive bone cement: An in vitro biomechanical study

Spine

Volumn 37, Issue 17, 2012, Pages

  Zhu, Qingan ^a   Kingwell, Stephen ^a   Li, Zhaoyang ^b   Pan, Haobo ^b   Lu, William W ^b   Oxland, Thomas R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

biomechanics; bone cement; lumbar vertebra; osteoporosis; pedicle screw fixation; polymethylmethacrylate; strontium hydroxyapatite

Indexed keywords

BIOACTIVE BONE CEMENT; BONE CEMENT; GENTAMICIN BONE CEMENT; HYDROXYAPATITE; STRONTIUM; UNCLASSIFIED DRUG;

AGING; ARTICLE; CADAVER; COMPUTER ASSISTED TOMOGRAPHY; FRACTURE FIXATION; HUMAN; KINEMATICS; MUSCULOSKELETAL SYSTEM PARAMETERS; OSSIFICATION; OSTEOPOROSIS; PEDICLE SCREW; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BIOMECHANICS; BONE CEMENTS; BONE SCREWS; CADAVER; DURAPATITE; FEMALE; HUMANS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; ORTHOPEDIC PROCEDURES; OSTEOPOROSIS; POLYMETHYL METHACRYLATE; RANGE OF MOTION, ARTICULAR;

EID: 84864434410     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e31825a676e     Document Type: Article

References (31)

1. Heller KD, Prescher A, Schneider T, et al. Stability of different wiring techniques in segmental spinal instrumentation. An experimental study. Arch Orthop Trauma Surg 1998; 117: 96-9. (Pubitemid 28058568)
2. Noorda RJ, Wuisman PI, Fidler MW, et al. Severe progressive osteoporotic spine deformity with cardiopulmonary impairment in a young patient. A case report. Spine 1999; 24: 489-92. (Pubitemid 29120144)
3. Okuyama K, Abe E, Suzuki T, et al. Influence of bone mineral density on pedicle screw fixation: a study of pedicle screw fixation augmenting posterior lumbar interbody fusion in elderly patients. Spine J 2001; 1: 402-7. (Pubitemid 33378109)
4. Fransen P. Increasing pedicle screw anchoring in the osteoporotic spine by cement injection through the implant. Technical note and report of three cases. J Neurosurg Spine 2007; 7: 366-9. (Pubitemid 47480467)
5. Yi X, Wang Y, Lu H, et al. Augmentation of pedicle screw fixa-tion strength using an injectable calcium sulfate cement: an in vivo study. Spine 2008; 33: 2503-9.
6. Wittenberg RH, Lee KS, Shea M, et al. Effect of screw diameter, insertion technique, and bone cement augmentation of pedicular screw fixation strength. Clin Orthop Relat Res 1993; 278-87. (Pubitemid 23332151)
7. Hasegawa K, Takahashi HE, Uchiyama S, et al. An experimental study of a combination method using a pedicle screw and laminar hook for the osteoporotic spine. Spine 1997; 22: 958-62; discussion 963.
8. Yerby SA, Toh E, McLain RF. Revision of failed pedicle screws using hydroxyapatite cement. A biomechanical analysis. Spine 1998; 23: 1657-61. (Pubitemid 28433864)
9. Cook SD, Salkeld SL, Stanley T, et al. Biomechanical study of pedicle screw fixation in severely osteoporotic bone. Spine J 2004; 4: 402-8. (Pubitemid 38986981)
10. Renner SM, Lim TH, Kim WJ, et al. Augmentation of pedicle screw fixation strength using an injectable calcium phosphate cement as a function of injection timing and method. Spine 2004; 29: E212-6.
11. Tan JS, Kwon BK, Dvorak MF, et al. Pedicle screw motion in the osteoporotic spine after augmentation with laminar hooks, sublam-inar wires, or calcium phosphate cement: a comparative analysis. Spine 2004; 29: 1723-30. (Pubitemid 39079913)
12. Yazu M, Kin A, Kosaka R, et al. Efficacy of novel-concept pedicle screw fixation augmented with calcium phosphate cement in the osteoporotic spine. J Orthop Sci 2005; 10: 56-61. (Pubitemid 40193009)
13. Burval DJ, McLain RF, Milks R, et al. Primary pedicle screw augmentation in osteoporotic lumbar vertebrae: biomechanical analysis of pedicle fixation strength. Spine 2007; 32: 1077-83. (Pubitemid 46685984)
14. Frankel BM, D'Agostino S, Wang C. A biomechanical cadaveric analysis of polymethylmethacrylate-augmented pedicle screw fixa-tion. J Neurosurg Spine 2007; 7: 47-53. (Pubitemid 47071757)
15. Takigawa T, Tanaka M, Konishi H, et al. Comparative biomechani-cal analysis of an improved novel pedicle screw with sheath and bone cement. J Spinal Disord Tech 2007; 20: 462-7. (Pubitemid 47357505)
16. Becker S, Chavanne A, Spitaler R, et al. Assessment of different screw augmentation techniques and screw designs in osteoporotic spines. Eur Spine J 2008; 17: 1462-9.
17. Chang MC, Liu CL, Chen TH. Polymethylmethacrylate augmentation of pedicle screw for osteoporotic spinal surgery: a novel technique. Spine 2008; 33: E317-24.
18. Kiner DW, Wybo CD, Sterba W, et al. Biomechanical analysis of different techniques in revision spinal instrumentation: larger diameter screws versus cement augmentation. Spine 2008; 33: 2618-22.
19. Frankel BM, Jones T, Wang C. Segmental polymethylmethacrylate-augmented pedicle screw fixation in patients with bone softening caused by osteoporosis and metastatic tumor involvement: a clinical evaluation. Neurosurgery 2007; 61: 531-7. (Pubitemid 47447909)
20. Kim YJ, Lee JW, Park KW, et al. Pulmonary cement embolism after percutaneous vertebroplasty in osteoporotic vertebral compression fractures: incidence, characteristics, and risk factors. Radiology 2009; 251: 250-9.
21. Röllinghoff M, Siewe J, Eysel P, et al. Pulmonary cement embolism after augmentation of pedicle screws with bone cement. Acta Orthop Belg 2010; 76: 269-73.
22. Li ZY, Yang C, Lu WW, et al. Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement. J Biomed Mater Res B Appl Biomater 2007; 83: 464-71. (Pubitemid 350005018)
23. Ni GX, Lu WW, Tang B, et al. Effect of weight-bearing on bone-bonding behavior of strontium-containing hydroxyapatite bone cement. J Biomed Mater Res A 2007; 83: 570-6. (Pubitemid 47557407)
24. Li Z, Lu WW, Chiu PK, et al. Strontium-calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model. J Orthop Res 2009; 27: 758-62.
25. Peng S, Zhou G, Luk KD, et al. Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway. Cell Physiol Biochem 2009; 23: 165-74.
26. Lotz JC, Hu SS, Chiu DF, et al. Carbonated apatite cement augmentation of pedicle screw fixation in the lumbar spine. Spine (Phila Pa 1976) 1997; 22: 2716-23. (Pubitemid 28100361)
27. Moore DC, Maitra RS, Farjo LA, et al. Restoration of pedicle screw fixation with an in situ setting calcium phosphate cement. Spine 1997; 22: 1696-705. (Pubitemid 28076400)
28. Rohmiller MT, Schwalm D, Glattes RC, et al. Evaluation of calcium sulfate paste for augmentation of lumbar pedicle screw pull-out strength. Spine J 2002; 2: 255-60.
29. Soshi S, Shiba R, Kondo H, et al. An experimental study on trans-pedicular screw fixation in relation to osteoporosis of the lumbar spine. Spine 1991; 16: 1335-41.
30. Law M, Tencer AF, Anderson PA. Caudo-cephalad loading of pedicle screws: mechanisms of loosening and methods of augmentation. Spine 1993; 18: 2438-43. (Pubitemid 24001352)
31. Tan JS, Kwon BK, Samarasekera D, et al. Vertebral bone density-a critical element in the performance of spinal implants. In: American Standards for Testing and Materials (ASTM) STP 1431, Melkerson MN, Griffith SL, Kirkpatrick JS, eds. Spinal Implants: Are We Evaluating Them Appropriately? West Conchohocken, PA: ASTM International; 2003: 217-30.