Studies of inhibitor binding to the [4Fe-4S] cluster of quinolinate synthase

Angewandte Chemie - International Edition

Volumn 51, Issue 31, 2012, Pages 7711-7714

  Chan, Alice ^a   Clémancey, Martin ^a   Mouesca, Jean Marie ^a   Amara, Patricia ^b   Hamelin, Olivier ^a   Latour, Jean Marc ^a   Ollagnier De Choudens, Sandrine ^a  

^a CEA GRENOBLE   (France)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

Author keywords

inhibitors; iron sulfur clusters; Moessbauer spectroscopy; NAD; quinolinate

Indexed keywords

E. COLI; FE SITES; IN-VIVO; INHIBITORY EFFECT; IRON-SULFUR CLUSTERS; MOSSBAUER; NAD; NICOTINAMIDE ADENINE DINUCLEOTIDES; QUINOLINATE; STRUCTURAL ANALOGUE; SYNTHASES; THIOLATES;

AMIDES; BIOCHEMISTRY; CORROSION INHIBITORS; ESCHERICHIA COLI; SULFUR;

BIOSYNTHESIS;

DIHYDROXYACETONE PHOSPHATE; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; IRON SULFUR PROTEIN; QUINOLINATE SYNTHASE, E COLI; TRANSFERASE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; BINDING SITES; DIHYDROXYACETONE PHOSPHATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; IRON-SULFUR PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864416971     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201202261     Document Type: Article

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