Selectivity Enhancement Arising from Interactions at the PI3K Unique Pocket

ChemMedChem

Volumn 7, Issue 8, 2012, Pages 1379-1383

  Jeong, Yujeong ^a   Lee, Junghyun ^b   Lee, Yoonji ^b   Ham, Kyungrok ^a   Choi, Sun ^b   Hong, Sungwoo ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

Cancer; Inhibitors; Kinases; Molecular modeling; Selectivity

Indexed keywords

BENZENESULFONAMIDE DERIVATIVE; N ( 5 ( 3 ( 5 METHYL 1,2,4 OXADIAZOL 3 YL)IMIDAZO[1,2 A]PYRIDIN 6 YL)PYRIDIN 3 YL)BENZENESULFONAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL METABOLISM; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR MODEL; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SUBSTITUTION REACTION;

BINDING SITES; CELL PROLIFERATION; COMPUTER SIMULATION; CYCLIN-DEPENDENT KINASE 2; HUMANS; MCF-7 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRIDINES;

EID: 84864416659     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200245     Document Type: Article

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