Liver involvement in hereditary hemorrhagic telangiectasia: Can breath test unmask impaired hepatic first-pass effect?

Internal and Emergency Medicine

Volumn 7, Issue 4, 2012, Pages 323-329

  Candelli, Marcello ^a   Pompili, Maurizio ^a   Suppressa, Patrizia ^b   Lenato, Gennaro M ^b   Bosco, Giulia ^a   Rapaccini, Gian Ludovico ^a   Gasbarrini, Antonio ^a   Scardapane, Arnaldo ^b   Sabbà, Carlo ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

First pass effect; Hepatic arteriovenous malformations; Hereditary hemorrhagic telangiectasia; Methacetin breath test

Indexed keywords

AMINOPHENAZONE; DIAGNOSTIC AGENT;

ADULT; AGED; ARTERIOVENOUS MALFORMATION; ARTICLE; BREATH ANALYSIS; CASE CONTROL STUDY; DRUG DETOXIFICATION; FEMALE; HUMAN; LIVER; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOLOGY; RENDU OSLER WEBER DISEASE;

ADULT; AGED; AMINOPYRINE; ARTERIOVENOUS MALFORMATIONS; BREATH TESTS; CASE-CONTROL STUDIES; FEMALE; HUMANS; LIVER; MALE; METABOLIC DETOXICATION, DRUG; MIDDLE AGED; TELANGIECTASIA, HEREDITARY HEMORRHAGIC; YOUNG ADULT;

EID: 84864411894     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-011-0531-9     Document Type: Article

References (40)

1. Govani FS, Shovlin CL (2009) Hereditary hemorrhagic telangiectasia: a clinical and scientific review. Eur J Hum Genet 17: 860-871.
2. Faughnan ME, Palda VA, Garcia-Tsao G, et al (2009) International guidelines for the diagnosis and management of hereditary hemorrhagic telangiectasia. J Med Genet. doi: 10. 1136/jmg. 2009. 069013.
3. Guttmacher AE, Marchuk DA, White RI Jr (1995) Hereditary hemorrhagic telangiectasia. N Engl J Med 333: 918-924.
4. Prigoda NL, Savas S, Abdalla SA et al (2006) Hereditary haemorrhagic telangiectasia: mutation detection, test sensitivity and novel mutations. J Med Genet 43: 722-728.
5. Lenato GM, Lastella P, Di Giacomo MC et al (2006) DHPLC-based mutation analysis of ENG and ALK-1 genes in the HHT Italian population. Hum Mutat 27: 213-214.
6. Sabba C, Gallitelli M, Pasculli G et al (2006) HHT: a rare disease with a broad spectrum of clinical aspects. Curr Pharm Des 12: 1217-1220.
7. Sabba C, Pasculli G, Lenato GM et al (2007) Hereditary hemorrhagic telangiectasia: clinical features in ENG and ALK1 mutation carriers. J Thromb Haemost 5: 1149-1157.
8. Gincul R, Lesca G, Gelas-Dore B et al (2008) Evaluation of previously non-screened hereditary hemorrhagic telangiectasia patients shows frequent liver involvement and early cardiac consequences. Hepatology 48: 1570-1576.
9. Garcia-Tsao G, Korzenik JR, Young L et al (2000) Liver disease in patients with hereditary hemorrhagic telangiectasia. N Engl J Med 28: 931-936.
10. Buscarini E, Plauchu H, Garcia Tsao G (2006) Liver involvement in hereditary hemorrhagic telangiectasia: consensus recommendations. Liver Int 26: 1040-1046.
11. Ianora AA, Memeo M, Sabba C et al (2004) Hereditary hemorrhagic telangiectasia: multi-detector row helical CT assessment of hepatic involvement. Radiology 230: 250-259.
12. Buonamico P, Suppressa P, Lenato GM et al (2008) Liver involvement in a large cohort of patients with hereditary hemorrhagic telangectasia: echo-color Doppler versus multislice CT study. J Hepatol 48: 811-820.
13. Verbeeck RK (2008) Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. Eur J Clin Pharmacol 64: 1147-1161.
14. Armuzzi A, Candelli M, Zocco MA et al (2002) Review article: breath testing for human liver function assessment. Aliment Pharmacol Ther 16: 1977-1996.
15. Streetman DS, Bertino JS Jr, Nafziger AN (2000) Phenotyping of drug metabolizing enzymes in adults: a review of in vivo cytochrome P450 phenotyping probes. Pharmacogenetics 10: 187-216.
16. Rivory LP, Slaviero KA, Hoskins JM et al (2001) The erythromycin breath test for the prediction of drug clearance. Clin Pharmacokinet 40: 151-158.
17. Vaira D, Gatta L, Ricci C et al (2010) A comparison amongst three rapid urease tests to diagnose Helicobacter pylori infection in 375 consecutive dyspeptic. Intern Emerg Med 5: 41-47.
18. Degre D, Bourgeois N, Boon N et al (2004) Aminopyrine breath test compared to the MELD and Child-Pugh scores for predicting mortality among cirrhotic patients awaiting liver transplantation. Transpl Int 17: 31-38.
19. Di Campli C, Angelini G, Armuzzi A et al (2003) Quantitative evaluation of liver function by the methionine and aminopyrine breath tests in the early stages of liver transplantation. Eur J Gastroenterol Hepatol 15: 727-732.
20. 13C-methacetin breath test as liver function test in patients with chronic hepatitis C virus infection. Aliment PharmacolTher 21: 179-185.
21. Brockmöller J, Roots I (1994) Assessment of liver metabolic function: clinical implications. Clin Pharmacokinet 27: 216-248.
22. Baron A, Gulberg V, Sauter G et al (1998) Effects of transjugular intrahepatic portosystemic shunt (TIPS) on quantitative liver function tests. Hepatogastroenterology 45: 2315-2321.
23. Fimognari LF, Violi F (2008) Portal vein thrombosis in liver cirrhosis. Intern Emerg Med 3: 213-218.
24. Shovlin CL, Guttmacher AE, Buscarini E et al (2000) Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Am J Med Genet 91: 66-67.
25. Wu JS, Saluja S, Garcia-Tsao G et al (2006) Liver involvement in hereditary hemorrhagic telangiectasia: CT and clinical findings do not correlate in symptomatic patients. AJR Am J Roentgenol 187: 399-405.
26. Buscarini E, Danesino C, Olivieri C (2004) Doppler ultrasonography grading of hepatic malformations of hereditary haemorrhagic telangiectasia. Ultraschall Med 25: 348-355.
27. Milot L, Kamaoui I, Gautier G et al (2008) Hereditary-hemorrhagic telangiectasia: one-step magnetic resonance examination in evaluation of liver involvement. Gastroenterol Clin Biol 32: 677-685.
28. Garcia-Tsao G, Swanson K (2008) Hepatic vascular malformations in hereditary hemorrhagic telangiectasia: in search for predictors of significant disease. Hepatology 48: 1377-1379.
29. Sawabe M, Arai T, Esaki Y et al (2001) Three-dimensional organization of the hepatic microvasculature in hereditary hemorrhagic telangiectasia. Arch Pathol Lab Med 125: 1219-1223.
30. 13C-methacetin breath test. Aliment Pharmacol Ther 17: 271-277.
31. Lankisch TO, Schulz C, Zwingers T et al (2008) Gilbert's syndrome and Irinotecan toxicity: combination with UDP-glucuronosyl transferase 1A7 variants increases risk. Cancer Epidemiol Biomarkers Prev 17: 695-701.
32. Mouly S, Rizzo-Padoin N, Simoneau G et al (2006) Effect of widely used combinations of antiretroviral therapy on liver CYP3A4 activity in HIV-infected patients. Br J Clin Pharmacol 62: 200-209.
33. Cakaloglu Y, Tredger JM, Devlin J et al (1994) Importance of cytochrome P-450IIIA activity in determining dosage and blood levels of FK 506 and cyclosporine in liver transplant recipients. Hepatology 20: 309-316.
34. Ghosh K, Ghosh K (2008) Hereditary haemorrhagic telangiectasia (HHT): negotiating between the Scylla of bleeding and Charybdis of thrombosis. Thromb Haemost 100: 162-164.
35. Gillum LA, Mamidipudi SK, Johnston SC (2000) Ischemic stroke risk with oral contraceptives: a meta-analysis. JAMA 284: 72-78.
36. Shovlin CL, Sulaiman NL, Govani FS et al (2007) Elevated Factor VIII in hereditary hemorrhagic telangiectasia: association with venous thromboembolism. Thromb Haemost 98: 1031-1039.
37. Borges NC, Barrientos Astigarraga R, Sverdloffa CE et al (2009) A novel and sensitive method for ethinylestradiol quantification in human plasma by high-performance liquid chromatography coupled to atmospheric pressure photoionization (APPI) tandem mass spectrometry: application to a comparative pharmacokinetics study. J Chromatogr B 877: 3601-3609.
38. Albiñana V, Bernabeu-Herrero ME, Zarrabeitia R et al (2010) Estrogen therapy for hereditary haemorrhagic telangiectasia (HHT): effects of raloxifene on Endoglin and ALK1 expression in endothelial cell. Thromb Haemost 103: 525-534.
39. Kemp DC, Fan PW, Stevens JC (2002) Characterization of Raloxifene glucuronidation: contribution of intestinal metabolism to presystemic clearance. Drug Metab Disp 30: 694-700.
40. Matsuo M, Kanematsu M, Kato H et al (2001) Osler-Weber-Rendu disease: visualizing portovenous shunting with three-dimensional sonography. AJR Am J Roentgenol 176: 919-920.