A novel and sensitive method for ethinylestradiol quantification in human plasma by high-performance liquid chromatography coupled to atmospheric pressure photoionization (APPI) tandem mass spectrometry: Application to a comparative pharmacokinetics study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 29, 2009, Pages 3601-3609

  Borges, Ney Carter ^a,b   Astigarraga, Rafael Barrientos ^c   Sverdloff, Carlos Eduardo ^a,b   Galvinas, Paulo Rabelo ^c   da Silva, Washington Moreira ^c   Rezende, Vinícius Marcondes ^a   Moreno, Ronilson Agnaldo ^a,b  

^a Synchrophar Assessoria e Desenvolvimento de Projetos Clinicos   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c State University of Campinas ^*  (Brazil)

Author keywords

APPI; Bioequivalence; Ethinylestradiol; Mass spectrometry; Pharmacokinetics; Plasma

Indexed keywords

ACCURACY AND PRECISION; ANALYTES; ANALYTICAL COLUMNS; APPI; AREA UNDER THE CURVES; ATMOSPHERIC PRESSURE PHOTO IONIZATION; BIOEQUIVALENCE; CONFIDENCE INTERVAL; CROSSOVER DESIGN; DIETHYL ETHERS; ETHINYLESTRADIOL; HUMAN PLASMAS; INTER-ASSAY PRECISION; INTERNAL STANDARDS; INTRA-ASSAY PRECISION; LINEAR CALIBRATION CURVE; LIQUID-LIQUID EXTRACTION; ON-LINE SOLID PHASE EXTRACTION; ROBUST METHODS; ROOM TEMPERATURE; RUNTIMES; SENSITIVE METHOD; SHORT TERM STABILITY; TABLET FORMULATIONS; TANDEM MASS SPECTROMETRY; US FOOD AND DRUG ADMINISTRATION; VALIDATION PROCESS;

ATMOSPHERIC PRESSURE; CHROMATOGRAPHIC ANALYSIS; COLUMN CHROMATOGRAPHY; DRUG PRODUCTS; ETHERS; HEXANE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PHARMACOKINETICS; PHOTOIONIZATION; PLASMA (HUMAN); PLASMA STABILITY; PLASMAS; SOLVENT EXTRACTION;

HIGH PRESSURE LIQUID CHROMATOGRAPHY;

CYPROTERONE; DIANE; ETHINYLESTRADIOL; SELENE; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ARTICLE; ATMOSPHERIC PRESSURE PHOTOIONIZATION TANDEM MASS SPECTROMETRY; BIOEQUIVALENCE; BRAZIL; DRUG BLOOD LEVEL; DRUG FORMULATION; ESTROGEN BLOOD LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; TABLET FORMULATION; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ETHINYL ESTRADIOL; HUMANS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 72149096028     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.08.048     Document Type: Article

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