Connexin45 Is expressed in vascular smooth muscle but its function remains elusive

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Schmidt, Volker J ^a,c   Jobs, Alexander ^a   von Maltzahn, Julia ^b   Wörsdörfer, Philipp ^b   Willecke, Klaus ^b   de Wit, Cor ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE; CONNEXIN 45; CRE RECOMBINASE; ENHANCED GREEN FLUORESCENT PROTEIN; NESTIN; POTASSIUM ION; RENIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERIOLE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; CREMASTER MUSCLE; CREMASTERIC ARTERIOLE; ENDOTHELIUM CELL; GENE DELETION; GENOTYPE; LOXP SITE; MICROSCOPY; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RENIN RELEASE; SMOOTH MUSCLE FIBER; TELEMETRY; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE; VASOMOTOR REFLEX;

ANIMALS; ARTERIOLES; BLOOD PRESSURE; CONNEXINS; GENE EXPRESSION REGULATION; INTEGRASES; MICE; MICROCIRCULATION; MUSCLE, SMOOTH, VASCULAR; VASOCONSTRICTION; VASODILATION;

MURINAE; MUS; MUS MUSCULUS;

EID: 84864411547     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042287     Document Type: Article

References (55)

1. de Wit C,((2004)) Connexins pave the way for vascular communication. News Physiol Sci 19:: 148--153.
2. Segal SS,((2005)) Regulation of blood flow in the microcirculation. Microcirculation 12:: 33--45.
3. de Wit C, Wölfle SE,((2007)) EDHF and gap junctions: important regulators of vascular tone within the microcirculation. Curr Pharm Biotechnol 8:: 11--25.
4. Welsh DG, Segal SS,((1998)) Endothelial and smooth muscle cell conduction in arterioles controlling blood flow. Am J Physiol 274:: H178--H186.
5. Siegl D, Koeppen M, Wölfle SE, Pohl U, de Wit C,((2005)) Myoendothelial coupling is not prominent in arterioles within the mouse cremaster microcirculation in vivo. Circ Res 97:: 781--788.
6. Kumar NM, Gilula NB,((1996)) The gap junction communication channel. Cell 84:: 381--388.
7. Söhl G, Willecke K,((2004)) Gap junctions and the connexin protein family. Cardiovasc Res 62:: 228--232.
8. Figueroa XF, Isakson BE, Duling BR,((2004)) Connexins: gaps in our knowledge of vascular function. Physiology (Bethesda) 19:: 277--284.
9. Haefliger JA, Nicod P, Meda P,((2004)) Contribution of connexins to the function of the vascular wall. Cardiovasc Res 62:: 345--356.
10. Wagner C,((2008)) Function of connexins in the renal circulation. Kidney Int 73:: 547--555.
11. Hakim CH, Jackson WF, Segal SS,((2008)) Connexin isoform expression in smooth muscle cells and endothelial cells of hamster cheek pouch arterioles and retractor feed arteries. Microcirculation 15:: 503--514.
12. van Veen TA, van Rijen HV, Jongsma HJ,((2000)) Electrical conductance of mouse connexin45 gap junction channels is modulated by phosphorylation. Cardiovasc Res 46:: 496--510.
13. Bukauskas FF, Verselis VK,((2004)) Gap junction channel gating. Biochim Biophys Acta 1662:: 42--60.
14. Rackauskas M, Kreuzberg MM, Pranevicius M, Willecke K, Verselis VK, et al.((2007)) Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45. Biophys J 92:: 1952--1965.
15. Johnstone S, Isakson B, Locke D,((2009)) Biological and biophysical properties of vascular connexin channels. Int Rev Cell Mol Biol 278:: 69--118.
16. Koval M, Billaud M, Straub AC, Johnstone SR, Zarbock A, et al.((2011)) Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43. Am J Pathol 178:: 2536--2546.
17. Scheckenbach KEL, Crespin S, Kwak BR, Chanson M,((2011)) Connexin channel-dependent signaling pathways in inflammation. J Vasc Res 48:: 91--103.
18. Figueroa XF, Duling BR,((2009)) Gap junctions in the control of vascular function. Antioxid Redox Signal 11:: 251--266.
19. Brisset AC, Isakson BE, Kwak BR,((2009)) Connexins in vascular physiology and pathology. Antioxid Redox Signal 11:: 267--282.
20. Liao Y, Regan CP, Manabe I, Owens GK, Day KH, et al.((2007)) Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury. Arterioscler Thromb Vasc Biol 27:: 1037--1042.
21. de Wit C, Roos F, Bolz SS, Kirchhoff S, Krüger O, et al.((2000)) Impaired conduction of vasodilation along arterioles in connexin40 deficient mice. Circ Res 86:: 649--655.
22. Figueroa XF, Paul DL, Simon AM, Goodenough DA, Day KH, et al.((2003)) Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo. Circ Res 92:: 793--800.
23. Milkau M, Köhler R, de Wit C,((2010)) Crucial importance of the endothelial K+ channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction. FASEB J 24:: 3572--3579.
24. Figueroa XF, Duling BR,((2008)) Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction. Am J Physiol Heart Circ Physiol 295:: H2001--H2007.
25. de Wit C,((2010)) Different pathways with distinct properties conduct dilations in the microcirculation in vivo. Cardiovasc Res 85:: 604--613.
26. Alonso F, Krattinger N, Mazzolai L, Simon A, Waeber G, et al.((2010)) An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension. Cardiovasc Res 87:: 166--176.
27. Krüger O, Plum A, Kim JS, Winterhager E, Maxeiner S, et al.((2000)) Defective vascular development in connexin 45-deficient mice. Development 127:: 4179--4193.
28. Kumai M, Nishii K, Nakamura K, Takeda N, Suzuki M, et al.((2000)) Loss of connexin45 causes a cushion defect in early cardiogenesis. Development 127:: 3501--3512.
29. Hanner F, von Maltzahn J, Maxeiner S, Toma I, Sipos A, et al.((2008)) Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure. Am J Physiol Regul Integr Comp Physiol 295:: R371--R380.
30. von Maltzahn J, Kreuzberg MM, Matern G, Euwens C, Hoher T, et al.((2009)) C-terminal tagging with eGFP yields new insights into expression of connexin45 but prevents rescue of embryonic lethal connexin45-deficient mice. Eur J Cell Biol 88:: 481--494.
31. Maxeiner S, Dedek K, Janssen-Bienhold U, Ammermuller J, Brune H, et al.((2005)) Deletion of connexin45 in mouse retinal neurons disrupts the rod/cone signaling pathway between AII amacrine and ON cone bipolar cells and leads to impaired visual transmission. J Neurosci 25:: 566--576.
32. Schubert T, Maxeiner S, Krüger O, Willecke K, Weiler R,((2005)) Connexin45 mediates gap junctional coupling of bistratified ganglion cells in the mouse retina. J Comp Neurol 490:: 29--39.
33. Kachinsky AM, Dominov JA, Miller JB,((1994)) Myogenesis and the intermediate filament protein, nestin. Dev Biol 165:: 216--228.
34. Michalczyk K, Ziman M,((2005)) Nestin structure and predicted function in cellular cytoskeletal organisation. Histol Histopathol 20:: 665--671.
35. Kisanuki YY, Hammer RE, Miyazaki J, Williams SC, Richardson JA, et al.((2001)) Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo. Dev Biol 230:: 230--242.
36. Wölfle SE, Schmidt VJ, Hoyer J, Köhler R, de Wit C,((2009)) Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo. Cardiovasc Res 82:: 476--483.
37. Wagner C, Jobs A, Schweda F, Kurtz L, Kurt B, et al.((2010)) Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension. Kidney Int 78:: 762--768.
38. Bolz SS, Galle J, Derwand R, de Wit C, Pohl U,((2000)) OxLDL increase the sensitivity of the contractile apparatus in isolated resistance arteries for Ca2+ via a Rho- and Rho-kinase-dependent mechanism. Circulation 102:: 2402--2410.
39. Wölfle SE, Schmidt VJ, Hoepfl B, Gebert A, Alcolea S, et al.((2007)) Connexin45 cannot replace the function of connexin40 in conducting endothelium-dependent dilations along arterioles. Circ Res 101:: 1292--1299.
40. Boettcher M, de Wit C,((2011)) Distinct endothelium-derived hyperpolarizing factors emerge in vitro and in vivo and are mediated in part via connexin 40-dependent myoendothelial coupling. Hypertension 57:: 802--808.
41. Li X, Simard JM,((2002)) Increase in Cx45 gap junction channels in cerebral smooth muscle cells from SHR. Hypertension 40:: 940--946.
42. Just A, Kurtz L, de Wit C, Wagner C, Kurtz A, et al.((2009)) Connexin 40 mediates the tubuloglomerular feedback contribution to renal blood flow autoregulation. J Am Soc Nephrol 20:: 1577--1585.
43. Schweda F, Kurtz L, de Wit C, Janssen-Bienhold U, Kurtz A, et al.((2009)) Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension. Kidney Int 75:: 482--489.
44. Kurtz L, Janssen-Bienhold U, Kurtz A, Wagner C,((2009)) Connexin expression in renin-producing cells. J Am Soc Nephrol 20:: 506--512.
45. Rummery NM, Hickey H, McGurk G, Hill CE,((2002)) Connexin37 is the major connexin expressed in the media of caudal artery. Arterioscler Thromb Vasc Biol 22:: 1427--1432.
46. Ko YS, Coppen SR, Dupont E, Rothery S, Severs NJ,((2001)) Regional differentiation of desmin, connexin43, and connexin45 expression patterns in rat aortic smooth muscle. Arterioscler Thromb Vasc Biol 21:: 355--364.
47. Ujiie H, Chaytor AT, Bakker LM, Griffith TM,((2003)) Essential role of gap junctions in NO- and prostanoid-independent relaxations evoked by acetylcholine in rabbit intracerebral arteries. Stroke 34:: 544--550.
48. Hilgen G, von Maltzahn J, Willecke K, Weiler R, Dedek K,((2011)) Subcellular distribution of connexin45 in OFF bipolar cells of the mouse retina. J Comp Neurol 519:: 433--450.
49. Rodenwaldt B, Pohl U, de Wit C,((2007)) Endogenous and exogenous NO attenuates conduction of vasoconstrictions along arterioles in the microcirculation. Am J Physiol Heart Circ Physiol 292:: H2341--H2348.
50. Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, et al.((2009)) Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension. Circulation 119:: 2323--2332.
51. de Wit C, Griffith TM,((2010)) Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses. Pflugers Arch 459:: 897--914.
52. Li X, Simard JM,((2001)) Connexin45 gap junction channels in rat cerebral vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 281:: H1890--H1898.
53. Kurt B, Kurtz L, Sequeira-Lopez ML, Gomez RA, Willecke K, et al.((2011)) Reciprocal expression of connexin 40 and 45 during phenotypical changes in renin-secreting cells. Am J Physiol Renal Physiol 300:: F743--F748.
54. Nishii K, Kumai M, Egashira K, Miwa T, Hashizume K, et al.((2003)) Mice lacking connexin45 conditionally in cardiac myocytes display embryonic lethality similar to that of germline knockout mice without endocardial cushion defect. Cell Commun Adhes 10:: 365--369.
55. Zlomuzica A, Reichinnek S, Maxeiner S, Both M, May E, et al.((2010)) Deletion of connexin45 in mouse neurons disrupts one-trial object recognition and alters kainate-induced gamma-oscillations in the hippocampus. Physiol Behav 101:: 245--253.