Radiosynthesis of [ 11C]SNAP-7941-the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1)

Applied Radiation and Isotopes

Volumn 70, Issue 10, 2012, Pages 2287-2294

  Philippe, C ^a,b   Schirmer, E ^b   Mitterhauser, M ^a,b   Shanab, K ^b   Lanzenberger, R ^a   Karanikas, G ^a   Spreitzer, H ^b   Viernstein, H ^b   Wadsak, W ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Carbon 11; MCHR1; PET; Radioligand; SNAP 7941

Indexed keywords

CARBON-11; HORMONE RECEPTORS; HUMAN DISORDERS; MCHR1; METHYLATION AGENTS; OPTIMUM REACTION CONDITIONS; RADIOCHEMICAL YIELD; RADIOLIGANDS; RADIOSYNTHESIS; REACTION TEMPERATURE; SNAP-7941;

ACETONITRILE; ALKYLATION; POLYETHYLENE TEREPHTHALATES;

CARBON;

3 [3 [4 (3 ACETAMINDOOPHENYL)PIPERIDIN 1 YL]PROPYLCARBAMOYL] 4 (3,4 DIFLUOROPHENYL) 6 (METHOXYMETHYL) 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; 5 (METHOXYACETYL) 2,2 DIMETHYL 1,3 DIOXANE 4,6 DIONE; ACETONITRILE; ALLYL 3 [3 [4 (3 ACETAMINDOOPHENYL)PIPERIDIN 1 YL]PROPYLCARBAMOYL] 4 (3,4 DIFLUOROPHENYL) 6 (METHOXYMETHYL) 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ESTER; CARBON 11; MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; METHYL 3 [[[3 [4 [3 (ACETYLAMINO)PHENYL] 1 PIPERIDINYL]PROPYL]AMINO]CARBONYL] 4 (3,4 DIFLUOROPHENYL) 6 (METHOXYMETHYL) 2 OXO 1,2,3,4 TETRAHYDRO 5 PYRIMIDINECARBOXYLATE C 11; METHYL 3 [[[3 [4 [3 (ACETYLAMINO)PHENYL] 1 PIPERIDINYL]PROPYL]AMINO]CARBONYL] 4 (3,4 DIFLUOROPHENYL) 6 (METHOXYMETHYL) 2 OXO 1,2,3,4 TETRAHYDRO 5 PYRIMIDINECARBOXYLIC ACID; N [3 (PIPERIDIN 4 YL)PHENYL]ACETAMIDE; PROP 2 EN 1 YL 3 [(3 BROMOPROPYL)CARBAMOYL] 4 (3,4 DIFLUOROPHENYL) 6 (METHOXYMETHYL) 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; PROP 2 EN 1 YL 4 (3,4 DIFLUOROPHENYL) 6 (METHOXYMETHYL) 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID; PROP 2 EN 1 YL 4 METHOXY 3 OXOBUTANOIC ACID; SNAP 7941; TRACER; UNCLASSIFIED DRUG; 3 [[3 [4 (3 ACETAMIDOPHENYL) 1 PIPERIDINYL]PROPYL]CARBAMOYL] 4 (3,4 DIFLUOROPHENYL) 1,2,3,4 TETRAHYDRO 6 (METHOXYMETHYL) 2 OXO 5 PYRIMIDINECARBOXYLIC ACID METHYL ESTER; CARBON; MCH1R PROTEIN, MOUSE; PIPERIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SOMATOSTATIN RECEPTOR;

ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; CONTROLLED STUDY; DRUG BINDING; DRUG FORMULATION; DRUG MECHANISM; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ISOTOPE LABELING; METHYLATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RADIATION DOSE; RADIOCHEMISTRY; REACTION TIME; STANDARD; TEMPERATURE; CHEMISTRY; HUMAN; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUALITY CONTROL; SYNTHESIS;

CARBON RADIOISOTOPES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; PYRIMIDINES; QUALITY CONTROL; RECEPTORS, SOMATOSTATIN;

EID: 84864408750     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2012.07.010     Document Type: Article

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