An example of designed multiple ligands spanning protein classes: Dual MCH-1R antagonists/DPPIV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2464-2469

  Gattrell, William T ^a   Sambrook Smith, Colin P ^a   Smith, Alun J ^b  

^a Prosidion Ltd   (United Kingdom)

^b Sygnature Discovery Limited   (United Kingdom)

Author keywords

Designed multiple ligands; DPPIV; MCH 1R; Type II diabetes

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; LIGAND; LINAGLIPTIN; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; PEPTIDE HYDROLASE INHIBITOR; SAXAGLIPTIN; SITAGLIPTIN;

ARTICLE; CONTROLLED STUDY; HUMAN; IN VITRO STUDY;

ANIMALS; ANTI-OBESITY AGENTS; CHO CELLS; CRICETINAE; DIPEPTIDASES; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; DRUG DESIGN; HUMANS; HYPOGLYCEMIC AGENTS; LIGANDS; PYRIDONES; RECEPTORS, SOMATOSTATIN;

EID: 84862800295     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.010     Document Type: Article

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