High-fat diet causes an imbalance in the colonic serotonergic system promoting adipose tissue enlargement and dysplasia in rats

Toxicology Letters

Volumn 213, Issue 2, 2012, Pages 135-141

  Kannen, Vinicius ^a,b   Zanette, Dalila L ^a   Fernandes, Cleverson R ^a   Ferreira, Frederico R ^a   Marini, Tassiana ^a   Carvalho, Milene C ^a   Brandão, Marcus L ^a   Junior, Jorge Elias ^a   Mauad, Fernando M ^a   Silva Jr , Wilson A ^a   Stopper, Helga ^b   Garcia, Sérgio B ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Angiogenesis; Colon dysplasia; Cyclooxygenase 2; High fat diet; Proliferation; Serotonergic system

Indexed keywords

CYCLOOXYGENASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY FAT DISTRIBUTION; CELL DENSITY; CELL PROLIFERATION; COLON CARCINOGENESIS; COLON DYSPLASIA; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DYSPLASIA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; INTRAABDOMINAL FAT; LIPID DIET; MALE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONINERGIC SYSTEM; WEIGHT GAIN;

ANIMALS; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; DIET, HIGH-FAT; DIETARY FATS; FEMALE; HYDROXYINDOLEACETIC ACID; IMMUNOHISTOCHEMISTRY; INTRA-ABDOMINAL FAT; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RNA; SEROTONIN;

RATTUS;

EID: 84864408240     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.06.014     Document Type: Article

References (33)

1. Amireault P., Dube F. Intracellular cAMP and calcium signaling by serotonin in mouse cumulus-oocyte complexes. Molecular Pharmacology 2005, 68:1678-1687.
2. Arutjunyan A.V., Kerkeshko G.O., Anisimov V.N., Stepanov M.G., Prokopenko V.M., Pozdeyev N.V., Korenevsky A.V. Disturbances of diurnal rhythms of biogenic amines contents in hypothalamic nuclei as an evidence of neurotropic effects of enterotropic carcinogen 1,2-dimethylhydrazine. Neuro Endocrinology Letters 2001, 22:229-237.
3. Bartsch H., Nair J., Owen R.W. Exocyclic DNA adducts as oxidative stress markers in colon carcinogenesis: potential role of lipid peroxidation, dietary fat and antioxidants. Biological Chemistry 2002, 383:915-921.
4. Calviello G., Di Nicuolo F., Gragnoli S., Piccioni E., Serini S., Maggiano N., Tringali G., Navarra P., Ranelletti F.O., Palozza P. n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. Carcinogenesis 2004, 25:2303-2310.
5. Cowey S.L., Quast M., Belalcazar L.M., Wei J., Deng X., Given R., Singh P. Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression. Cancer 2005, 103:2643-2653.
6. Erspamer V., Testini A. Observations on the release and turnover rate of 5-hydroxytryptamine in the gastrointestinal tract. Journal of Pharmacy and Pharmacology 1959, 11:618-623.
7. Garcia S.B., Park H.S., Novelli M., Wright N.A. Field cancerization, clonality, and epithelial stem cells: the spread of mutated clones in epithelial sheets. Journal of Pathology 1999, 187:61-81.
8. Garcia S.B., Barros L.T., Turatti A., Martinello F., Modiano P., Ribeiro-Silva A., Vespucio M.V., Uyemura S.A. The anti-obesity agent Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen. Cancer Letters 2006, 240:221-224.
9. Homberg J.R., la Fleur S.E., Cuppen E. Serotonin transporter deficiency increases abdominal fat in female, but not male rats. Obesity (Silver Spring) 2010, 18:137-145.
10. Huang X.F., Huang X., Han M., Chen F., Storlien L., Lawrence A.J. 5-HT2A/2C receptor and 5-HT transporter densities in mice prone or resistant to chronic high-fat diet-induced obesity: a quantitative autoradiography study. Brain Research 2004, 1018:227-235.
11. Huhnt W., Lubbe A.S. Venules and arterioles in xenotransplanted human colon adenocarcinoma critically constrict with hyperthermia and serotonin. Journal of Cancer Research and Clinical Oncology 1995, 121:267-274.
12. Ikeda K., Mutoh M., Teraoka N., Nakanishi H., Wakabayashi K., Taguchi R. Increase of oxidant-related triglycerides and phosphatidylcholines in serum and small intestinal mucosa during development of intestinal polyp formation in Min mice. Cancer Science 2011, 102:79-87.
13. Kannen V., Marini T., Turatti A., Carvalho M.C., Brandao M.L., Jabor V.A., Bonato P.S., Ferreira F.R., Zanette D.L., Silva W.A., Garcia S.B. Fluoxetine induces preventive and complex effects against colon cancer development in epithelial and stromal areas in rats. Toxicology Letters 2011, 204:134-140.
14. Kannen V., Marini T., Zanette D.L., Frajacomo F.T., Silva G.E., Silva W.A., Garcia S.B. The melatonin action on stromal stem cells within pericryptal area in colon cancer model under constant light. Biochemical and Biophysical Research Communications 2011, 405:593-598.
15. Kimbrough T.D., Weekley L.B. The effect of a high-fat diet on brainstem and duodenal serotonin (5-HT) metabolism in Sprague-Dawley and Osborne-Mendel rats. International Journal of Obesity 1984, 8:305-310.
16. la Fleur S.E., Vanderschuren L.J., Luijendijk M.C., Kloeze B.M., Tiesjema B., Adan R.A. A reciprocal interaction between food-motivated behavior and diet-induced obesity. International Journal of Obesity (London) 2007, 31:1286-1294.
17. Li J., Chen X., Xiao W., Ma W., Li T., Huang J., Liu X., Liang X., Tang S., Luo Y. Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells. Biochemical and Biophysical Research Communications 2011, 404:349-356.
18. Liang J.T., Huang K.C., Jeng Y.M., Lee P.H., Lai H.S., Hsu H.C. Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer. British Journal of Surgery 2004, 91:355-361.
19. Lubbe A.S., Huhnt W. Microvessel diameters of human colon adenocarcinoma during acute treatment with serotonin. International Journal of Microcirculation: Clinical and Experimental 1994, 14:218-225.
20. Mastrangelo L., Cassidy A., Mulholland F., Wang W., Bao Y. Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells. Cancer Research 2008, 68:5487-5491.
21. Nefti W., Chaumontet C., Fromentin G., Tome D., Darcel N. A high-fat diet attenuates the central response to within-meal satiation signals and modifies the receptor expression of vagal afferents in mice. American Journal of Physiology - Regulatory, Integrative, and Comparative Physiology 2009, 296:R1681-R1686.
22. Nocito A., Dahm F., Jochum W., Jang J.H., Georgiev P., Bader M., Graf R., Clavien P.A. Serotonin regulates macrophage-mediated angiogenesis in a mouse model of colon cancer allografts. Cancer Research 2008, 68:5152-5158.
23. Park S.W., Kim H.S., Choi M.S., Jeong W.J., Heo D.S., Kim K.H., Sung M.W. The effects of the stromal cell-derived cyclooxygenase-2 metabolite prostaglandin E2 on the proliferation of colon cancer cells. Journal of Pharmacology and Experimental Therapeutics 2011, 336:516-523.
24. Skinner S.A., Tutton P.J., O'Brien P.E. Microvascular architecture of experimental colon tumors in the rat. Cancer Research 1990, 50:2411-2417.
25. Stunes A.K., Reseland J.E., Hauso O., Kidd M., Tommeras K., Waldum H.L., Syversen U., Gustafsson B.I. Adipocytes express a functional system for serotonin synthesis, reuptake and receptor activation. Diabetes, Obesity and Metabolism 2011, 13:551-558.
26. Tammali R., Reddy A.B., Srivastava S.K., Ramana K.V. Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo. Angiogenesis 2011, 14:209-221.
27. Todaro M., Francipane M.G., Medema J.P., Stassi G. Colon cancer stem cells: promise of targeted therapy. Gastroenterology 2010, 138:2151-2162.
28. Valcz G., Krenacs T., Sipos F., Leiszter K., Toth K., Balogh Z., Csizmadia A., Muzes G., Molnar B., Tulassay Z. The role of the bone marrow derived mesenchymal stem cells in colonic epithelial regeneration. Pathology Oncology Research 2011, 17:11-16.
29. Wang W., Campiche M. Microvasculature of human colorectal epithelial tumors. An electron microscopic study. Virchows Archiv. A. Pathological Anatomy and Histology 1982, 397:131-147.
30. Wang B., Chehab F.F. Deletion of the serotonin 2c receptor from transgenic mice overexpressing leptin does not affect their lipodystrophy but exacerbates their diet-induced obesity. Biochemical and Biophysical Research Communications 2006, 351:418-423.
31. Wasan H.S., Novelli M., Bee J., Bodmer W.F. Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:3308-3313.
32. Wong W.M., Mandir N., Goodlad R.A., Wong B.C., Garcia S.B., Lam S.K., Wright N.A. Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission. Gut 2002, 50:212-217.
33. Yu Y., Fuhr J., Boye E., Gyorffy S., Soker S., Atala A., Mulliken J.B., Bischoff J. Mesenchymal stem cells and adipogenesis in hemangioma involution. Stem Cells 2006, 24:1605-1612.