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Volumn 22, Issue 16, 2012, Pages 5326-5329
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Pyrimidinopyrimidine inhibitors of ketohexokinase: Exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket
a,b,c
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Author keywords
Diabetes; Fructose metabolism; Kinase; Obesity
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Indexed keywords
(3 AMINO 8 AZA BICYCLO [3.2.1] OCTAN) 8 YL;
(PIPERIDIN 4 YL)CH2NME;
2 ME PIPERAZINO;
2,3,4,5 TETRAHYDRO 1H 1,4 BENZODIAZEPIN 4 YL;
2,5 DIAZABICYCLO [2.2.1] HEPT 2 YL;
2,6 DIAZASPIRO [3 4] OCTAN 6 YL;
2,6 DIAZASPIRO [3.3] HEPT 2 YL;
3 ME PIPERAZINO;
3,3 DI ME PIPERAZINO;
3,3' SPIRO(BIS PYRROLIDIN) 1 YL;
4 (4 ME PIPERAZIN 1 YL)PIPERIDINO;
4 (PIPERIDIN 1 YL)PIPERAZINO;
4 (PIPERIDIN 4 YL)PIPERAZINO;
4,4' SPIRO(BIS PIPERIDIN) 1 YL;
ABC TRANSPORTER;
AMMONIA;
CIS 2,6 DIME PIPERAZIN 4 YL;
CIS H8 6H PYRROLO[3,4 B]PYRIDIN 6 YL;
KETOHEXOKINASE;
PIPERAZINO;
PYRIMIDINE DERIVATIVE;
UNCLASSIFIED DRUG;
ARTICLE;
DRUG POTENCY;
ELECTROSPRAY MASS SPECTROMETRY;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
IC 50;
PHARMACOPHORE;
PROTON NUCLEAR MAGNETIC RESONANCE;
STRUCTURE ACTIVITY RELATION;
BINDING SITES;
COMPUTER SIMULATION;
CRYSTALLOGRAPHY, X-RAY;
ENZYME INHIBITORS;
FRUCTOKINASES;
HEP G2 CELLS;
HUMANS;
LIGANDS;
PROTEIN BINDING;
PROTEIN STRUCTURE, TERTIARY;
PYRIMIDINES;
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EID: 84864407458
PISSN: 0960894X
EISSN: 14643405
Source Type: Journal
DOI: 10.1016/j.bmcl.2012.06.008 Document Type: Article |
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Times cited : (11)
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References (18)
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