Electron density guided fragment-based lead discovery of ketohexokinase inhibitors

Journal of Medicinal Chemistry

Volumn 53, Issue 22, 2010, Pages 7979-7991

  Gibbs, Alan C ^a   Abad, Marta C ^a   Zhang, Xuqing ^a   Tounge, Brett A ^a   Lewandowski, Francis A ^a   Struble, Geoffrey T ^a   Sun, Weimei ^a   Sui, Zhihua ^a   Kuo, Lawrence C ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KETOHEXOKINASE; KETOHEXOKINASE INHIBITOR; N [3 (METHYLTHIO) 1 PHENYL 1H INDAZOL 6 YL]PIPERIDINE 4 CARBOXAMIDE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FRAGMENTATION REACTION; HYDROGEN BOND; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CRYSTALLOGRAPHY, X-RAY; ELECTRONS; FRUCTOKINASES; HUMANS; INDAZOLES; MALE; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649520607     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100677s     Document Type: Article

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