New horizons in sedative hypnotic drug development: Fast, clean, and soft

Anesthesia and Analgesia

Volumn 115, Issue 2, 2012, Pages 220-222

  Johnson, Ken B ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; ESMOLOL; ETOMIDATE; FENTANYL; HYPNOTIC SEDATIVE AGENT; MIDAZOLAM; MIVACURIUM; PROPOFOL; RAPACURONIUM BROMIDE; REMIFENTANIL; REMIMAZOLAM; SUFENTANIL;

ANESTHESIA INDUCTION; BISPECTRAL INDEX; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG METABOLISM; DRUG USE; HUMAN; INFUSION RATE; MONTE CARLO METHOD; PRIORITY JOURNAL; REVIEW; SEDATION; SIMULATION;

BENZODIAZEPINES; COMPUTER SIMULATION; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDAZOLAM; MODELS, BIOLOGICAL;

EID: 84864404436     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31825ef8d7     Document Type: Review

References (9)

1. Antonik LJ, Goldwater DR, Kilpatrick GJ, Tilbrook GS, Borkett KM. A placebo-and midazolam-controlled, phase I, single ascending dose study evaluating the safety, pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056): part I. Safety, efficacy and basic pharmacokinetics. Anesth Analg 2012;115:274-83
2. Wiltshire HR, Kilpatrick GJ, Tilbrook GS, Borkett KM. A placebo and midazolam-controlled phase I single ascending dose study evaluating the safety, pharmacokinetics and pharmacodynam-ics of remimazolam (CNS 7056): Part II. Population pharmaco-kinetic and pharmacodynamic modelling and simulation. Anesth Analg 2012;114:284-96
3. Ge RL, Pejo E, Haburcak M, Husain SS, Forman SA, Raines DE. Pharmacological studies of methoxycarbonyl etomidate's car-boxylic acid metabolite. Anesth Analg 2012;115:305-8
4. Pejo E, Cotten JF, Kelly EW, Ge RL, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE. In vivo and in vitro pharmacological studies of methoxycarbonyl- carboetomidate. Anesth Analg 2012;115:297-304
5. Bodor N, Buchwald P. Soft drug design: general principles and recent applications. Med Res Rev 2000;20:58-101 (Pubitemid 30027561)
6. Bloomfield R, Noble DW. Etomidate and fatal outcome-even a single bolus dose may be detrimental for some patients. Br J Anaesth 2006;97:116-7
7. Jackson WL Jr. Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock? A critical appraisal. Chest 2005;127:1031-8 (Pubitemid 40775537)
8. Hughes MA, Glass PS, Jacobs Jr. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology 1992;76:334-41
9. Johnson K, Egan T. Principles of pharmacokinetics and phar-macodynamics: applied clinical pharmacology for the practitioner. In: Longnecker D, Brown D, Newman M, Zapol W, eds. Anesthesiology. 1st ed. New York: McGraw Hill, 2008:821-48