SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 16, 2012, Pages 5297-5302

Development of 'DFG-out' inhibitors of gatekeeper mutant kinases

(6) Choi, Hwan Geun a,c Zhang, Jianming a,c Weisberg, Ellen a Griffin, James D a Sim, Taebo a,b,c Gray, Nathanael S a,c

a DANA FARBER CANCER INSTITUTE (United States)

b Korea Institute of Science and Technology (South Korea)

c HARVARD MEDICAL SCHOOL (United States)

Author keywords

Gatekeeper mutant; Kinase inhibitor; T315I Bcr Abl; Thiazolo 5,4 b pyridine; Type II inhibitor

Indexed keywords

PROTEIN TYROSINE KINASE INHIBITOR;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; HYBRID; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; FUSION PROTEINS, BCR-ABL; HALF-LIFE; HYDROGEN BONDING; MICE; MUTATION; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

PYRONIA TITHONUS;

EID: 84864403909 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.06.036 Document Type: Article

Times cited : (8)

References (19)

1
- 0029947186
- B.J. Druker, S. Tamura, E. Buchdunger, S. Ohno, G.M. Segal, S. Fanning, J. Zimmermann, and N.B. Lydon Nat. Med. 2 1996 561
- (1996) Nat. Med. , vol.2 , pp. 561
- Druker, B.J.¹ Tamura, S.² Buchdunger, E.³ Ohno, S.⁴ Segal, G.M.⁵ Fanning, S.⁶ Zimmermann, J.⁷ Lydon, N.B.⁸

2
- 0035810142
- B.J. Druker, C.L. Sawyers, H. Kantarjian, D.J. Resta, S.F. Reese, J.M. Ford, R. Capdeville, and M.N. Talpaz Engl. J. Med. 344 2001 1038
- (2001) Engl. J. Med. , vol.344 , pp. 1038
- Druker, B.J.¹ Sawyers, C.L.² Kantarjian, H.³ Resta, D.J.⁴ Reese, S.F.⁵ Ford, J.M.⁶ Capdeville, R.⁷ Talpaz, M.N.⁸

3
- 13844251975
- E. Weisberg, P.W. Manley, W. Breitenstein, J. Bruggen, S.W. Cowan-Jacob, A. Ray, B. Huntly, D. Fabbro, G. Fendrich, E. Hall-Meyers, A.L. Kung, J. Mestan, G.Q. Daley, L. Callahan, L. Catley, C. Cavazza, M. Azam, D. Neuberg, R.D. Wright, D.G. Gilliland, and J.D. Griffin Cancer Cell 7 2005 129
- (2005) Cancer Cell , vol.7 , pp. 129
- Weisberg, E.¹ Manley, P.W.² Breitenstein, W.³ Bruggen, J.⁴ Cowan-Jacob, S.W.⁵ Ray, A.⁶ Huntly, B.⁷ Fabbro, D.⁸ Fendrich, G.⁹ Hall-Meyers, E.¹⁰ Kung, A.L.¹¹ Mestan, J.¹² Daley, G.Q.¹³ Callahan, L.¹⁴ Catley, L.¹⁵ Cavazza, C.¹⁶ Azam, M.¹⁷ Neuberg, D.¹⁸ Wright, R.D.¹⁹ Gilliland, D.G.²⁰ Griffin, J.D.²¹ more..

4
- 3142676436
- N.P. Shah, C. Tran, F.Y. Lee, P. Chen, D. Norris, and C.L. Sawyers Science 305 2004 399
- (2004) Science , vol.305 , pp. 399
- Shah, N.P.¹ Tran, C.² Lee, F.Y.³ Chen, P.⁴ Norris, D.⁵ Sawyers, C.L.⁶

5
- 33845806858
- M. Puttini, A.M. Coluccia, F. Boschelli, L. Cleris, E. Marchesi, A. Donella-Deana, S. Ahmed, S. Redaelli, R. Piazza, V. Magistroni, F. Andreoni, L. Scapozza, F. Formelli, and C. Gambacorti-Passerini Cancer Res. 66 2006 11314
- (2006) Cancer Res. , vol.66 , pp. 11314
- Puttini, M.¹ Coluccia, A.M.² Boschelli, F.³ Cleris, L.⁴ Marchesi, E.⁵ Donella-Deana, A.⁶ Ahmed, S.⁷ Redaelli, S.⁸ Piazza, R.⁹ Magistroni, V.¹⁰ Andreoni, F.¹¹ Scapozza, L.¹² Formelli, F.¹³ Gambacorti-Passerini, C.¹⁴

6
- 13844251983
- T. O'Hare, D.K. Walters, M.W. Deininger, and B.J. Druker Cancer Cell 7 2005 117
- (2005) Cancer Cell , vol.7 , pp. 117
- O'Hare, T.¹ Walters, D.K.² Deininger, M.W.³ Druker, B.J.⁴

7
- 70350507997
- T. O'Hare, W.C. Shakespeare, X. Zhu, C.A. Eide, V.M. Rivera, F. Wang, L.T. Adrian, T. Zhou, W.-S. Huang, Q. Xu, C.A. Metcalf 3rd, J.W. Tyner, M.M. Loriaux, A.S. Corbin, S. Wardwell, Y. Ning, J.A. Keats, Y. Wang, R. Sundaramoorthi, M. Thomas, D. Zhou, J. Snodgrass, L. Commodore, T.K. Sawyer, D.C. Dalgarno, M.W.N. Deininger, B.J. Druker, and T. Clackson Cancer Cell 16 2009 401
- (2009) Cancer Cell , vol.16 , pp. 401
- O'Hare, T.¹ Shakespeare, W.C.² Zhu, X.³ Eide, C.A.⁴ Rivera, V.M.⁵ Wang, F.⁶ Adrian, L.T.⁷ Zhou, T.⁸ Huang, W.-S.⁹ Xu, Q.¹⁰ Metcalf III, C.A.¹¹ Tyner, J.W.¹² Loriaux, M.M.¹³ Corbin, A.S.¹⁴ Wardwell, S.¹⁵ Ning, Y.¹⁶ Keats, J.A.¹⁷ Wang, Y.¹⁸ Sundaramoorthi, R.¹⁹ Thomas, M.²⁰ more..

8
- 79955485779
- C.A. Eide, L.T. Adrian, J.W. Tyner, M. MacPartlin, D.J. Anderson, S.C. Wise, B.D. Smith, P.A. Petillo, D.L. Flynn, M.W.N. Deininger, T. O'Hare, and B.J. Druker Cancer Res. 71 2011 3189
- (2011) Cancer Res. , vol.71 , pp. 3189
- Eide, C.A.¹ Adrian, L.T.² Tyner, J.W.³ MacPartlin, M.⁴ Anderson, D.J.⁵ Wise, S.C.⁶ Smith, B.D.⁷ Petillo, P.A.⁸ Flynn, D.L.⁹ Deininger, M.W.N.¹⁰ O'Hare, T.¹¹ Druker, B.J.¹²

9
- 84864414962
- Program of the Fall Meeting 2008. CHIMIA International Journal for, Chemistry 2008, 62(7-8), pp 547-557.
- (2008) Program of the Fall Meeting 2008. CHIMIA International Journal For, Chemistry , vol.62 , Issue.7-8 , pp. 547-557

10
- 77955367484
- H.G. Choi, P. Ren, F. Adrian, F. Sun, H.S. Lee, X. Wang, Q. Ding, G. Zhang, Y. Xie, J. Zhang, Y. Liu, T. Tuntland, M. Warmuth, P.W. Manley, J.R. Mestan, N.S. Gray, and T. Sim J. Med. Chem. 53 2010 5439
- (2010) J. Med. Chem. , vol.53 , pp. 5439
- Choi, H.G.¹ Ren, P.² Adrian, F.³ Sun, F.⁴ Lee, H.S.⁵ Wang, X.⁶ Ding, Q.⁷ Zhang, G.⁸ Xie, Y.⁹ Zhang, J.¹⁰ Liu, Y.¹¹ Tuntland, T.¹² Warmuth, M.¹³ Manley, P.W.¹⁴ Mestan, J.R.¹⁵ Gray, N.S.¹⁶ Sim, T.¹⁷

11
- 65549152514
- M.A. Seeliger, P. Ranjitkar, C. Kasap, Y. Shan, D.E. Shaw, N.P. Shah, J. Kuriyan, and D.J. Maly Cancer Res. 69 2009 2384
- (2009) Cancer Res. , vol.69 , pp. 2384
- Seeliger, M.A.¹ Ranjitkar, P.² Kasap, C.³ Shan, Y.⁴ Shaw, D.E.⁵ Shah, N.P.⁶ Kuriyan, J.⁷ Maly, D.J.⁸

12
- 77953871612
- X. Deng, S.M. Lim, J. Zhang, and N.S. Gray Bioorg. Med. Chem. Lett. 20 2010 4196
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 4196
- Deng, X.¹ Lim, S.M.² Zhang, J.³ Gray, N.S.⁴

13
- 77953636478
- E. Weisberg, H.G. Choi, A. Ray, R. Barrett, J. Zhang, T. Sim, W. Zhou, M. Seeliger, M. Cameron, M. Azam, J.A. Fletcher, M. Debiec-Rychter, M. Mayeda, D. Moreno, A.L. Kung, P.A. Janne, R. Khosravi-Far, J.V. Melo, P.W. Manley, S. Adamia, C. Wu, N. Gray, and J.D. Griffin Blood 115 2010 4206
- (2010) Blood , vol.115 , pp. 4206
- Weisberg, E.¹ Choi, H.G.² Ray, A.³ Barrett, R.⁴ Zhang, J.⁵ Sim, T.⁶ Zhou, W.⁷ Seeliger, M.⁸ Cameron, M.⁹ Azam, M.¹⁰ Fletcher, J.A.¹¹ Debiec-Rychter, M.¹² Mayeda, M.¹³ Moreno, D.¹⁴ Kung, A.L.¹⁵ Janne, P.A.¹⁶ Khosravi-Far, R.¹⁷ Melo, J.V.¹⁸ Manley, P.W.¹⁹ Adamia, S.²⁰ more..

14
- 77956600334
- E. Weisberg, H.G. Choi, R. Barrett, W. Zhou, J. Zhang, A. Ray, E.A. Nelson, J. Jiang, D. Moreno, R. Stone, I. Galinsky, E. Fox, S. Adamia, A.L. Kung, N.S. Gray, and J.D. Griffin Mol. Cancer Ther. 9 2010 2468
- (2010) Mol. Cancer Ther. , vol.9 , pp. 2468
- Weisberg, E.¹ Choi, H.G.² Barrett, R.³ Zhou, W.⁴ Zhang, J.⁵ Ray, A.⁶ Nelson, E.A.⁷ Jiang, J.⁸ Moreno, D.⁹ Stone, R.¹⁰ Galinsky, I.¹¹ Fox, E.¹² Adamia, S.¹³ Kung, A.L.¹⁴ Gray, N.S.¹⁵ Griffin, J.D.¹⁶

15
- 33746258750
- B. Okram, A. Nagle, F.J. Adrian, C. Lee, P. Ren, X. Wang, T. Sim, Y. Xie, G. Xia, G. Spraggon, M. Warmuth, Y. Liu, and N.S. Gray Chem. Biol. 13 2006 779
- (2006) Chem. Biol. , vol.13 , pp. 779
- Okram, B.¹ Nagle, A.² Adrian, F.J.³ Lee, C.⁴ Ren, P.⁵ Wang, X.⁶ Sim, T.⁷ Xie, Y.⁸ Xia, G.⁹ Spraggon, G.¹⁰ Warmuth, M.¹¹ Liu, Y.¹² Gray, N.S.¹³

16
- 33644784776
- J.S. Melnick, J. Janes, S. Kim, J.Y. Chang, D.G. Sipes, D. Gunderson, L. Jarnes, J.T. Matzen, M.E. Garcia, T.L. Hood, R. Beigi, G. Xia, R.A. Harig, H. Asatryan, S.F. Yan, Y. Zhou, X.J. Gu, A. Saadat, V. Zhou, F.J. King, C.M. Shaw, A.I. Su, R. Downs, N.S. Gray, P.G. Schultz, M. Warmuth, and J.S. Caldwell Proc. Natl. Acad. Sci. U.S.A. 103 2006 3153
- (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 3153
- Melnick, J.S.¹ Janes, J.² Kim, S.³ Chang, J.Y.⁴ Sipes, D.G.⁵ Gunderson, D.⁶ Jarnes, L.⁷ Matzen, J.T.⁸ Garcia, M.E.⁹ Hood, T.L.¹⁰ Beigi, R.¹¹ Xia, G.¹² Harig, R.A.¹³ Asatryan, H.¹⁴ Yan, S.F.¹⁵ Zhou, Y.¹⁶ Gu, X.J.¹⁷ Saadat, A.¹⁸ Zhou, V.¹⁹ King, F.J.²⁰ more..

17
- 0032495790
- Y. Nagao, T. Hirata, S. Goto, S. Sano, A. Kakehi, K. Iizuka, and M. Shiro J. Am. Chem. Soc. 120 1998 3104
- (1998) J. Am. Chem. Soc. , vol.120 , pp. 3104
- Nagao, Y.¹ Hirata, T.² Goto, S.³ Sano, S.⁴ Kakehi, A.⁵ Iizuka, K.⁶ Shiro, M.⁷

18
- 2342485125
- M.T. Bilodeau, L.D. Rodman, G.B. McGaughey, K.E. Coll, T.J. Koester, W.F. Hoffman, R.W. Hungate, R.L. Kendall, R.C. McFall, K.W. Rickert, R.Z. Rutledge, and K.A. Thomas Bioorg. Med. Chem. Lett. 14 2004 2941
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2941
- Bilodeau, M.T.¹ Rodman, L.D.² McGaughey, G.B.³ Coll, K.E.⁴ Koester, T.J.⁵ Hoffman, W.F.⁶ Hungate, R.W.⁷ Kendall, R.L.⁸ McFall, R.C.⁹ Rickert, K.W.¹⁰ Rutledge, R.Z.¹¹ Thomas, K.A.¹²

19
- 80755125575
- M.I. Davis, J.P. Hunt, S. Herrgard, P. Ciceri, L.M. Wodicka, G. Pallares, M. Hocker, D.K. Treiber, and P.P. Zarrinkar Nat. Biotechol. 29 2011 1046
- (2011) Nat. Biotechol. , vol.29 , pp. 1046
- Davis, M.I.¹ Hunt, J.P.² Herrgard, S.³ Ciceri, P.⁴ Wodicka, L.M.⁵ Pallares, G.⁶ Hocker, M.⁷ Treiber, D.K.⁸ Zarrinkar, P.P.⁹

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.