Optimisation of imidazole compounds as selective TAAR1 agonists: Discovery of RO5073012

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 16, 2012, Pages 5244-5248

  Galley, Guido ^a   Stalder, Henri ^a   Goergler, Annick ^a   Hoener, Marius C ^a   Norcross, Roger D ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Imidazole; SAR; TAAR1 agonist; Trace amines

Indexed keywords

(4 CHLOROPHENYL) (1H IMIDAZOL 4 YLMETHYL)ISOPROPYL AMINE; AMINE; IMIDAZOLE DERIVATIVE; RO5073012; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; RAT; SCHIZOPHRENIA;

ADMINISTRATION, ORAL; ANILINE COMPOUNDS; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HALF-LIFE; IMIDAZOLES; MICROSOMES; RATS; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS; RODENTIA;

EID: 84864399622     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.060     Document Type: Article

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