Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 159-174

  Puig De La Bellacasa, Raimon ^a   Giménez, Laura ^a   Pettersson, Sofia ^a   Pascual, Rosalia ^a   Gonzalo, Encarna ^b   Esté, José A ^b   Clotet, Bonaventura ^b   Borrell, José I ^a   Teixidó, Jordi ^a  

^a INSTITUT QUÍMIC DE SARRIÀ   (Spain)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

Antiviral activity; Combinatorial design; Diversity selection HIV 1; NNRTIs HEPT

Indexed keywords

1 [(2 HYDROXYETHOXY)METHYL] 6 (PHENYLTHIO)THYMINE; 2,4,6 TRICHLOROPYRIMIDINE; 5 METHYLBARBITURIC ACID; 5 METHYLTHIOBARBITURIC ACID; 6 CHLORO 1 ( 2 TRIMETHYLSILYL)ETHOXYMETHYLTHYMINE; 6 CHLORO 1 ( 2 TRIMETHYLSILYL)ETHOXYMETHYLURACIL; 6 CHLORO 1 ( 2,5 DIMETHYLBENZYL)THYMINE; 6 CHLORO 1 ( 2,5 DIMETHYLBENZYL)URACIL; 6 CHLORO 1 (( 4 CHLOROPHENOXY)METHYL)THYMINE; 6 CHLORO 1 (ETHOXYMETHYL)THYMINE; 6 CHLORO 1 (ETHOXYMETHYL)URACIL; 6 CHLOROTHYMINE; 6 CHLOROURACIL; ANTIRETROVIRUS AGENT; BARBITURIC ACID; BARBITURIC ACID DERIVATIVE; BIS( 2,6 DICHLOROPHENYL)DISULFIDE; BIS( 3 AMINOPHENYL)DISULFIDE; BIS( 3 CHLOROPHENYL)DISULFIDE; DIPHENYL DISULFIDE; EFAVIRENZ; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PYRIMIDINE DERIVATIVE; RITONAVIR; THIOBARBITURIC ACID; THYMINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; URACIL DERIVATIVE; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL LINE; CHEMICAL ANALYSIS; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; SUBSTITUTION REACTION; VIRUS STRAIN;

CELL LINE; CHEMISTRY TECHNIQUES, SYNTHETIC; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; HIV REVERSE TRANSCRIPTASE; HIV-1; REVERSE TRANSCRIPTASE INHIBITORS; THYMINE;

EID: 84864398460     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.04.038     Document Type: Article

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