Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 8, 2012, Pages 4140-4145

  Horita, Yasuhiro ^a,c,g   Takii, Takemasa ^a   Yagi, Tetsuya ^b   Ogawa, Kenji ^c   Fujiwara, Nagatoshi ^d   Inagaki, Emi ^a   Kremer, Laurent ^e   Sato, Yasuo ^f   Kuroishi, Ryuji ^a   Lee, YooSa ^a   Makino, Toshiaki ^a   Mizukami, Hajime ^a   Hasegawa, Tomohiro ^a   Yamamoto, Ryuji ^a   Onozaki, Kikuo ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY HOSPITAL   (Japan)

^c Meito ku   (Japan)

^d OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITÉ DE MONTPELLIER   (France)

^f MEIJI SEIKA KAISHA LTD   (Japan)

^g RESEARCH INSTITUTE OF TUBERCULOSIS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DIETHYLDITHIOCARBAMIC ACID; DIETHYLDITHIOCARBAMIC ACID METHYL ESTER; DISULFIRAM; ETHAMBUTOL; ETHIONAMIDE; ISONIAZID; PYRROLIDINE DITHIOCARBAMATE; RIFAMPICIN; STREPTOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM ISOLATE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; DISULFIRAM; DITIOCARB; ENZYME INHIBITORS; EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84864386765     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.06445-11     Document Type: Article

References (34)

1. Baulard AR, et al. 2000. Activation of the pro-drug ethionamide is regulated in mycobacteria. J. Biol. Chem. 275:28326-28331.
2. Bouma MJ, Snowdon D, Fairlamb AH, Ackers JP. 1998. Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus. J. Antimicrob. Chemother. 42:817-820. (Pubitemid 29008086)
3. Brar SS, et al. 2004. Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease. Mol. Cancer Ther. 3:1049-1060. (Pubitemid 39295002)
4. Byrne ST, et al. 2007. Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 51:4495-4497. (Pubitemid 350209912)
5. Camps M, Boothroyd JC. 2001. Toxoplasma gondii: selective killing of extracellular parasites by oxidation using pyrrolidine dithiocarbamate. Exp. Parasitol. 98:206-214. (Pubitemid 32912751)
6. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed: approved standard M7-A7. Clinical and Laboratory Standards Institute, Wayne, PA.
7. Dover LG, et al. 2007. EthA, a common activator of thiocarbamide- containing drugs acting on different mycobacterial targets. Antimicrob. Agents Chemother. 51:1055-1063. (Pubitemid 46355295)
8. Faiman MD, Dodd DE, Hanzlik RE. 1978. Distribution of S35 disulfiram and metabolites in mice, and metabolism of S35 disulfiram in the dog. Res. Commun. Chem. Pathol. Pharmacol. 21:543-567. (Pubitemid 9022941)
9. Falzon D, et al. 2011. WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update. Eur. Respir. J. 38:516-528.
10. Foye WO. 1955. Metal chelates and antitubercular activity. II. p-Aminosalicylic acid. J. Am. Pharm. Assoc. Am. Pharm. Assoc. (Baltim.) 44:415-418.
11. Foye WO, Jeffrey JG. 1955. Metal chelates and antitubercular activity. I. o-Hydroxyazo naphthols and phenanthrols. J. Am. Pharm. Assoc. Am. Pharm. Assoc. (Baltim.) 44:257-260.
12. Foye WO, Duvall RN. 1958. Metal chelates and antitubercular activity. III. p-Aminosalicylic acid: chelate vs. complex. J. Am. Pharm. Assoc. 47:282-285.
13. Garattini S, Leonardi A. 1955. Tuberculostatic action of chelating substances; preliminary note. G. Ital. Chemioter. 2:18-22. (In Italian.)
14. Hald J, Jacobsen E. 1948. A drug sensitizing the organism to ethyl alcohol. Lancet ii:1001-1004.
15. Horita Y, et al. 2009. Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis. Bioorg. Med. Chem. Lett. 19:6313-6316.
16. Horita Y, et al. 2011. Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. Bioorg. Med. Chem. Lett. 21:899-903.
17. Hubner L, Ernst M, von Laer D, Schwander S, Flad HD. 1991. Enhancement of monocyte antimycobacterial activity by diethyldithiocarbamate (DTC). Int. J. Immunopharmacol. 13:1067-1072.
18. Jeney E, Zsolnai T. 1956. Experiments for the detection of new tuberculostatics. IV. Chemotherapeutic action of some hydrazine derivatives, and organic sulfur compounds on the experimental tuberculosis of guinea pigs. Zentralbl. Bakteriol. Orig. 167:254-264. (In German.)
19. Khan S, Singhal S, Mathur T, Upadhyay DJ, Rattan A. 2007. Antifungal potential of disulfiram. Nippon Ishinkin Gakkai Zasshi 48:109-113. (Pubitemid 350099307)
20. Maresca A, Carta F, Vullo D, Supuran CT. 6 December 2011. Dithiocarbamates strongly inhibit the beta-class carbonic anhydrases from Mycobacterium tuberculosis. J. Enzyme Inhib Med. Chem. [Epub ahead of print.]
21. Matsumoto M, et al. 2006. OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS Med. 3:e466. doi:10.1371/journal.pmed.0030466.
22. Meshnick SR, Scott MD, Lubin B, Ranz A, Eaton JW. 1990. Antimalarial activity of diethyldithiocarbamate. Potentiation by copper. Biochem. Pharmacol. 40:213-216. (Pubitemid 20218835)
23. Murray PR, Baron EJ (ed). 2007. Manual of clinical microbiology, 9th ed. ASM Press, Washington, DC.
24. Nash T, Rice WG. 1998. Efficacies of zinc-finger-active drugs against Giardia lamblia. Antimicrob. Agents Chemother. 42:1488-1492. (Pubitemid 28257655)
25. National Committee for Clinical Laboratory Standards. 1999. Methodology for the serum bactericidal test. Approved guideline M21-A, vol 19. National Committee for Clinical Laboratory Standards, Wayne, PA.
26. Nishimori I, et al. 2010. The beta-carbonic anhydrases from Mycobacterium tuberculosis as drug targets. Curr. Pharm. Des. 16:3300-3309.
27. Phillips M, Malloy G, Nedunchezian D, Lukrec A, Howard RG. 1991. Disulfiram inhibits the in vitro growth of methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 35:785-787.
28. Rosenthal B, et al. 1997. Evidence for the bacterial origin of genes encoding fermentation enzymes of the amitochondriate protozoan parasite Entamoeba histolytica. J. Bacteriol. 179:3736-3745. (Pubitemid 27233017)
29. Taylor EH, Walker EM, Jr, Bartelt M, Day S, Pappas AA. 1987. In vitro antimicrobial activity of diethyldithiocarbamate and dimethyldithiocarbamate against methicillin-resistant Staphylococcus. Ann. Clin. Lab. Sci. 17:171-177. (Pubitemid 17071093)
30. Thorn GD, Ludwig RA. 1962. The dithiocarbamates and related compounds. Elsevier, Amsterdam, The Netherlands.
31. Vonk WI, Wijmenga C, van de Sluis B. 2008. Relevance of animal models for understanding mammalian copper homeostasis. Am. J. Clin. Nutr. 88:840S-845S.
32. Wallace RJ, Jr, Nash DR, Steele LC, Steingrube V. 1986. Susceptibility testing of slowly growing mycobacteria by a microdilution MIC method with 7H9 broth. J. Clin. Microbiol. 24:976-981. (Pubitemid 17193352)
33. Yamane N, et al. 1999. Multicenter evaluation of broth microdilution test, BrothMIC MTB, to determine minimum inhibitory concentrations (MICs) of antimicrobial agents for Mycobacterium tuberculosis-evaluation of interlaboratory precision and interpretive compatibility with agar proportion method. Rinsho Byori 47:754-766. (In Japanese.)
34. Zajaczkowski H. 1949. Treatment of chronic alcoholism with a sensitizing drug. Pol. Tyg. Lek. (Wars.) 4:504. (In undetermined language.)