Activity of disulfiram (bis(diethylthiocarbamoyl)disulphide) and ditiocarb (diethyldithiocarbamate) against metronidazole-sensitive and -resistant Trichomonas vaginalis and Tritrichomonas foetus

Journal of Antimicrobial Chemotherapy

Volumn 42, Issue 6, 1998, Pages 817-820

  Bouma, Menno J ^a   Snowdon, Diane ^a   Fairlamb, Alan H ^a,b   Ackers, John P ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLDITHIOCARBAMIC ACID; DISULFIRAM; IMIDAZOLE DERIVATIVE; IMMUNOSTIMULATING AGENT; METRONIDAZOLE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG RESISTANCE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; TRICHOMONAS FOETUS; TRICHOMONAS VAGINALIS;

AEROBIOSIS; ANAEROBIOSIS; ANIMALS; ANTIPROTOZOAL AGENTS; ANTITRICHOMONAL AGENTS; DISULFIRAM; DITIOCARB; DRUG RESISTANCE; METRONIDAZOLE; TRICHOMONAS VAGINALIS; TRITRICHOMONAS FOETUS;

EID: 0032418144     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/42.6.817     Document Type: Article

References (10)

1. World Health Organization. (1995). An overview of selected curable sexually transmitted diseases. WHO/GPA/STD/95.1, pp. 1-13.
2. Müller, M., Lossick, J. G. & Gorrell, T. E. (1988). In vitro susceptibility of Trichomonas vaginalis to metronidazole and treatment outcome in vaginal trichomoniasis. Sexually Transmitted Diseases 15, 17-24.
3. Jeney, E. & Zsolnai, T. (1964). Versuche zur chemotherapeutischen Beenflussung der durch Trichomonas vaginalis hervorgerufenen Infektionen. Zentralblatt für Bakteriologie, Parasitenkunde und Infektionskrankheiten 193, 542-7.
4. Ackers, J. P. (1995). Trichomonads. In Medical Parasitology: A Practical Approach (Gillespie, S. H. & Hawkey, P. M., Eds), pp. 137-50. IRL Press, Oxford.
5. Diamond, L. S., Harlow, D. R. & Cunnick, C. C. (1978). A new medium for the axenic cultivation of Entamoeba histolytica and other Entamoeba. Transactions of the Royal Society of Tropical Medicine and Hygiene 72, 431-2.
6. 2 in healthy women and in women infected with Trichomonas vaginalis: potential implications for metronidazole therapy. American Journal of Obstetrics and Gynecology 166, 620-4.
7. Malcolm, M. T. (1977). Disulfiram blood levels. British Medical Journalii , 457.
8. Sauter, A. M., Wiegrebe, W. & von Wartburg, J. P. (1976). Determination of disulfiram and its metabolites in human blood. Arzneimittel-Forschung 26, 173-7.
9. Johansson, B. (1992). A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites. Acta Psychiatrica Scandinavica Supplementum 369, 15-26.
10. Carper, W. R., Dorey, R. C. & Beber, J. H. (1987). Inhibitory effect of disulfiram (Antabuse) on alcohol dehydrogenase activity. Clinical Chemistry 33, 1906-8.