Berbamine protects the heart from ischemia/reperfusion injury by maintaining cytosolic Ca2+ homeostasis and preventing calpain activation

Circulation Journal

Volumn 76, Issue 8, 2012, Pages 1993-2002

  Zhang, Cai Mei ^a,b   Gao, Ling ^a,b   Zheng, Yan Jun ^a,b   Yang, Huang Tian ^a,b,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Berbamine; Ca2+ overloading; Calpain; Ischemia reperfusion; Pi3K Akt GSK3

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BERBAMINE; CALPAIN; CALPASTATIN; DESMIN; GLYCOGEN SYNTHASE KINASE 3BETA; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; HEART LEFT VENTRICLE PERFORMANCE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; MUSCLE FIBER CONTRACTION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; WESTERN BLOTTING;

ANDROSTADIENES; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZYLISOQUINOLINES; CALCIUM; CALPAIN; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; ENZYME ACTIVATION; MALE; MUSCLE PROTEINS; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84864384787     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-11-1431     Document Type: Article

References (35)

1. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007; 357: 1121-1135.
2. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986; 74: 1124-1136.
3. 2+ overload in cardiomyocytes. Cardiovasc Res 2007; 75: 584-595.
4. Liao PH, Hung LM, Chen YH, Kuan YH, Zhang FB, Lin RH, et al. Cardioprotective effects of luteolin during ischemia-reperfusion injury in rats. Circ J 2011; 75: 443-450.
5. Thuc LC, Teshima Y, Takahashi N, Nishio S, Fukui A, Kume O, et al. Cardioprotective effects of pravastatin against lethal ventricular arrhythmias induced by reperfusion in the rat heart. Circ J 2011; 75: 1601-1608.
6. Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, et al. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis. J Immunol 2008; 181: 1491-1498.
7. Wang S, Liu Q, Zhang Y, Liu K, Yu P, Liu K, et al. Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Mol Cancer 2009; 8: 81.
8. Guo ZB, Fu JG. Progress of cardiovascular pharmacologic study on berbamine. Zhongguo Zhong Xi Yi Jie He Za Zhi 2005; 25: 765-768.
9. 2+-independent mechanism. J Cardiovasc Pharmacol 2011; 58: 40-48.
10. Li BY, Yang BF, Li WH. Effects of berbamine on hemodynamics and myocardial reperfusion injury in isolated working rabbit hearts. Zhongguo Yao Li Xue Bao 1991; 12: 48-52.
11. Zhang W, Chen SG, Ju HS, Zhao SH, Zou CM, Hao JM, et al. Mechanisms of protective effects of berbamine on ischemia/reperfusion injury in isolated rat heart. Methods Find Exp Clin Pharmacol 1992; 14: 677-684.
12. 2+ exchange mechanisms. Am J Physiol Cell Physiol 2006; 290: C1221-C1229.
13. Fraser H, Belardinelli L, Wang L, Light PE, McVeigh JJ, Clanachan AS. Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol 2006; 41: 1031-1038.
14. Singh RB, Chohan PK, Dhalla NS, Netticadan T. The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart. J Mol Cell Cardiol 2004; 37: 101-110.
15. Blunt BC, Creek AT, Henderson DC, Hofmann PA. H2O2 activation of HSP25/27 protects desmin from calpain proteolysis in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 2007; 293: H1518-H1525.
16. Inserte J, Barba I, Hernando V, Garcia-Dorado D. Delayed recovery of intracellular acidosis during reperfusion prevents calpain activation and determines protection in postconditioned myocardium. Cardiovasc Res 2009; 81: 116-122.
17. Ban K, Cooper AJ, Samuel S, Bhatti A, Patel M, Izumo S, et al. Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ Res 2008; 103: 643-653.
18. Gross ER, Hsu AK, Gross GJ. GSK3β inhibition and KATP channel opening mediate acute opioid-induced cardioprotection at reperfusion. Basic Res Cardiol 2007; 102: 341-349.
19. Crisostomo PR, Wairiuko GM, Wang M, Tsai BM, Morrell ED, Meldrum DR. Preconditioning versus postconditioning: Mechanisms and therapeutic potentials. J Am Coll Surg 2006; 202: 797-812.
20. Cao CM, Zhang Y, Weisleder N, Ferrante C, Wang X, Lv F, et al. Mg53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation 2010; 121: 2565-2574.
21. Lecour S. Activation of the protective survivor activating factor enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the risk pathway? J Mol Cell Cardiol 2009; 47: 32-40.
22. Hausenloy DJ, Tsang A, Mocanu MM, Yellon DM. Ischemic preconditioning protects by activating prosurvival kinases at reperfusion. Am J Physiol Heart Circ Physiol 2005; 288: H971-H976.
23. Xie Y, Zhu Y, Zhu WZ, Chen L, Zhou ZN, Yuan WJ, et al. Role of dual-site phospholamban phosphorylation in intermittent hypoxiainduced cardioprotection against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2005; 288: H2594-H2602.
24. Wang ZH, Chen YX, Zhang CM, Wu L, Yu Z, Cai XL, et al. Intermittent hypobaric hypoxia improves postischemic recovery of myocardial contractile function via redox signaling during early reperfusion. Am J Physiol Heart Circ Physiol 2011; 301: H1695-H1705.
25. Xu H, Yang YJ, Qian HY, Tang YD, Wang H, Zhang Q. Rosuvastatin treatment activates jak-stat pathway and increases efficacy of allogeneic mesenchymal stem cell transplantation in infarcted hearts. Circ J 2011; 75: 1476-1485.
26. Nanduri J, Wang N, Yuan G, Khan SA, Souvannakitti D, Peng YJ, et al. Intermittent hypoxia degrades HIF-2α via calpains resulting in oxidative stress: Implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci USA 2009; 106: 1199-1204.
27. 2+-dependent proteolysis. Cell Mol Life Sci 2003; 60: 2669-2678.
28. Hausenloy DJ, Tsang A, Yellon DM. The reperfusion injury salvage kinase pathway: A common target for both ischemic preconditioning and postconditioning. Trends Cardiovasc Med 2005; 15: 69-75.
29. Li NY, Li WH, Li Y. Effects of berbamine on the isolated myocardium in guinea pigs and humans. Zhongguo Yao Li Xue Bao 1986; 7: 222-226.
30. Inserte J, Garcia-Dorado D, Hernando V, Barba I, Soler-Soler J. Ischemic preconditioning prevents calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion. Cardiovasc Res 2006; 70: 364-373.
31. 2+ exchanger by m-calpain in isolated endoplasmic reticulum. J Biochem 2010; 147: 225-235.
32. Tong H, Imahashi K, Steenbergen C, Murphy E. Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3-kinase-dependent pathway is cardioprotective. Circ Res 2002; 90: 377-379.
33. Kim SO, Baines CP, Critz SD, Pelech SL, Katz S, Downey JM, et al. Ischemia induced activation of heat shock protein 27 kinases and casein kinase 2 in the preconditioned rabbit heart. Biochem Cell Biol 1999; 77: 559-567.
34. Strohm C, Barancik T, Bruhl ML, Kilian SA, Schaper W. Inhibition of the ER-kinase cascade by PD98059 and UO126 counteracts ischemic preconditioning in pig myocardium. J Cardiovasc Pharmacol 2000; 36: 218-229.
35. Kamada N, Kanaya N, Hirata N, Kimura S, Namiki A. Cardioprotective effects of propofol in isolated ischemia-reperfused guinea pig hearts: Role of KATP channels and GSK-3β. Can J Anaesth 2008; 55: 595-605.