Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 8, 2012, Pages 4207-4213

  Shahinas, Dea ^a   MacMullin, Gregory ^b   Benedict, Christan ^c   Crandall, Ian ^a   Pillaid, Dylan R ^d  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; CHLOROQUINE; HARMALOL; HARMINE; HEAT SHOCK PROTEIN 90;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG TARGETING; HUMAN; MOUSE; NONHUMAN; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CHLOROQUINE; DRUG SYNERGISM; HARMALINE; HARMINE; HSP90 HEAT-SHOCK PROTEINS; MALARIA; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE;

EID: 84864383670     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00328-12     Document Type: Article

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