Antimalarial activity of extracts and alkaloids isolated from six plants used in traditional medicine in Mali and Sao Tome

Phytotherapy Research

Volumn 16, Issue 7, 2002, Pages 646-649

  Ancolio, C ^a   Azas, N ^a   Mahiou, V ^a   Ollivier, E ^a   Di Giorgio, C ^a   Keita, A ^b   Timon David, P ^a   Balansard, G ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Laboratoire de Pharmacognosie   (Mali)

Author keywords

Flow cytometry; Plasmodium falciparum; Traditional medicinal plants

Indexed keywords

ALKALOID; HARMAN; PLANT EXTRACT; TETRAHYDROHARMAN; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; BLOOD SMEAR; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALI; MEDICINAL PLANT; MONOCYTE; PLANT LEAF; PLASMODIUM FALCIPARUM; PROTEIN SYNTHESIS INHIBITION; RUBIACEAE; SAO TOME AND PRINCIPE; TRADITIONAL MEDICINE;

ALKALOIDS; ANIMALS; ANTIMALARIALS; ATLANTIC ISLANDS; CELL CYCLE; CELL LINE; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; MALI; MEDICINE, AFRICAN TRADITIONAL; MONOCYTES; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS; PLANT STEMS; PLANTS, MEDICINAL; PLASMODIUM FALCIPARUM;

APODANTHERA; COMBRETACEAE; COMBRETUM; FERETIA; MORINDA; MORINDA CITRIFOLIA; MYRISTICACEAE; PLASMODIUM FALCIPARUM; POLYGALACEAE; PYCNANTHUS ANGOLENSIS; RUBIACEAE; SECURIDACA;

EID: 0036846482     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1025     Document Type: Article

References (12)

1. Combier H, Becchi M, Cavé A. 1977. Alcaloides du Guiera Senegalensis. Plantes Méd Phytothér XI: 251-253.
2. Crissman H, Darzinkiewick Z, Tobey R, Steinkamp J. 1985. Correlated measurements of DNA, RNA and protein in individual cells by flow cytometry. Cytometry 228: 1321-1324.
3. Funayama Y, Nishio K, Wakabayashi K et al. 1996. Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities. Mutat Res 349: 183-191.
4. Herrraiz T. 2000. Tetrahydro-beta-carboline-3-carboxylic acid compounds in fish and meat: Possible precursors of comutagenic beta-carbolines norharman and harman in cooked foods. Food Addit Contam 17: 859-866.
5. Picada JN, Da Silva KV, Erdtmann B, Henriques AT, Henriques JA. 1997. Genotoxic effects of structurally related beta-carboline alkaloids. Mutat Res 379: 135-149.
6. Plowe V, Djimde A, Bouare M et al. 1995. Pyrimethamine and proguanil resistance-conferring mutation in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg 52: 565-568.
7. Tragger W, Jensen JB. 1978. Cultivation of malarial parasites. Nature 273: 621.
8. Van der Heyde HC, Elloso MM, Vande Waa J, Schell K, Weidanz W. 1995. Use of hydroethidine and flow cytometry to assess the effects leucocytes on the malarial parasite. Clin Diagn Lab Immunol 2: 417-425.
9. WHO 1994. World malaria situation in 1992. Wkly Epidemiol Rec 42: 309-314.
10. Willey L. 1995. Mathematical modelisation of cell cycle from flow cytometry data. Cytometry 14: 471-500.
11. Wright CW, Phillipson JD. 1990. Natural products and the development of selective antiprotozoal drugs. Phytother Res 4: 127-139.
12. Wyatt C, Goff W, Davis W. 1991. A flow cytometric method for assessing viability of intraerythrocytic hemoparasites. J Immunol Meth 140: 23-30.