Osteoporotic treatment options in geriatric patients;Therapie der Osteoporose beim geriatrischen Patienten

Zeitschrift fur Gerontologie und Geriatrie

Volumn 45, Issue 5, 2012, Pages 417-429

  Gosch, M ^a   Kammerlander, C ^b   Pils, K ^c   Lechleitner, M ^a   Benvenuti Falger, U ^a   Roth, T ^b   Joosten Gstrein, B ^a   Pietschmann, P ^d  

^a Abteilung fur Innere Medizin und Akutgeriatrie   (Austria)

^b Universitatsklinik fur Chirurgie Innsbruck   (Austria)

^c Institut für Physikalische Medizin und Rehabilitation   (Austria)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Drug therapy; Geriatric assessment; Osteoporosis; Osteoporotic fractures; Preventive measures

Indexed keywords

AGED; ARTICLE; FEMALE; FRAGILITY FRACTURE; GERIATRIC ASSESSMENT; HUMAN; MALE; METHODOLOGY; OSTEOPOROSIS;

AGED; AGED, 80 AND OVER; FEMALE; GERIATRIC ASSESSMENT; HUMANS; MALE; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES;

EID: 84864357065     PISSN: 09486704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00391-012-0336-0     Document Type: Article

References (62)

1. Leung F, Blauth M, Bavonratanavech S (2010) Surgery for fracture - streamlining the process. Osteoporos Int 21(Suppl 4):519-552
2. Bartl R (2008) Osteoporose - Prävention - Diagnostik - Therapie. Thieme, Stuttgart, S1-2
3. Becker C, Gebhard F, Muche R et al (1999) Epidemiologie der Stürze Älterer. Z Orthop 137:482-485
4. Häussler B, Gothe H, Göl D et al (2007) Epidemiology, treatment and costs of osteoporosis in Germany - the BoneEVA Study. Osteoporos Int 18(1):77-84
5. Pietschmann P, Azizi-Semrad U, Pils K et al (2010) Pharmacologic undertreatment of osteoporosis in Austrian nursing homes and senior's residences. Wien Klin Wochenschr 122:532-537
6. Kammerlander C, Gosch M, Kammerlander-Knauer U et al (2011) Long-term functional outcome in geriatric hip fracture patients. Arch Orthop Trauma Surg 131(10):1435-1444
7. Jennings LA, Auerbach AD, Maselli J et al (2010) Missed opportunities for osteoporosis treatment in patients hospitalized for hip fracture. J Am Geriatr Soc 58:650-657
8. Gosch M, Roth T, Kammerlander C et al (2011) Treatment of osteoporosis in postmenopausal hip fracture patients after geriatric rehabilitation: changes over the last decade. Z Gerontol Geriatr 44(6):381-386
9. DVO (2009) DVO-Leitlinien 2009. http://www.dv-osteologie.org/dvo_leitlinien/dvo-leitlinie-2009. Zugegriffen:?
10. Solomon DH, Avorn J, Katz JN et al (2005) Compliance with osteoporosis medications. Arch Intern Med 165(20):2414-2419
11. American Geriatrics Society, British Geriatrics Society, and American Academy of Orthopaedic Surgeons Panel on Falls Prevention (2001) Guideline for the prevention of falls in older persons. J Am Geriatr Soc 49:664
12. Zhu K, Devine A, Lewis JR et al (2011) 'Timed up and go' test and bone mineral density measurement for fracture prediction. Arch Intern Med 171(18)
13. Chapuy MC, Arlot ME, Duboef F et al (1992) Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 327:1637-1642
14. Dawson-Hughes B, Harris S, Krall EA et al (1997) Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337:670-676
15. Schacht E, Kneer W, Dambacher MA (2008) Die Wirkung von Alfacalcidol auf den Muskel, das neuromuskuläre System, auf die Sturzgefahr und auf Frakturen. J Mineralstoffwechsel 15(3):132-139
16. Bischoff-Ferrari HA, Dawson-Hoghes B, Willett WC et al (2004) Effect of vitamin D on falls: a meta-analysis. JAMA 291:1999-2006
17. Bischoff-Ferrari HA, Willett WC, Wong JB et al (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293:2257-2264
18. Deschasse G, Chavanne D, Dardaine- Giraud V et al (2009) Effect of a loading dose of vitamin D3 in frail elderly patients with insufficient 25-hydroxyvitamin D serum levels. J Am Geriatr Soc 57:2155-2156
19. Ettinger B, Black DM, Mitlak BH et al (1999) Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA 282(7):637-645
20. Ensrud KE, Stock JL, Barrett-Connor E et al (2008) Effects of raloxifen on fracture risk in postmenopausal women: the raloxifen use for the heart trial. J Bone Miner Res 23:112-120
21. Chesnut CH, Silverman S, Andriano K et al (2000) A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study. PROOF Study Group. Am J Med 109(4):267-276
22. Inderjeeth CA, Foo ACH, Lai MMY et al (2009) Efficacy and safety of pharmacological agents in managing osteoporosis in the old old: review of the literature. Bone 44:744-751
23. Boonen S, Klemes AB, Zhou X, Lindsay R (2010) Assessment of the relationship between age and the effect of risedronate treatment in women with postmenopausal osteoporosis: a pooled analysis of four studies. J Am Geriatr Soc 58:658-663
24. Weycker D, Macarios D, Edelsberg J et al (2007) Compliance with osteoporosis drug therapy and risk of fracture. Osteoporos Int 18(3):271-277
25. Feldstein AC et al (2009) Effectiveness of bisphosphonate therapy in a community setting. Bone 44:153-159
26. Pyon EY (2006) Once-monthly ibandronate for postmenopausal osteoporosis: review of a new dosing regimen. Clin Ther 28(4):475-490
27. Lyles KW, Colón-Emeric CS, Magaziner JS et al for the HORIZON Recurrent Fracture Trial (2007) Zoledronic acid in reducing clinical fracture and mortality after hip fracture. N Engl J Med 357
28. Boonen St, Black DM, Clon-Emeric CS et al (2010) Efficacy and safety of a once-yearly intravenous zoledronic acid 5 mg for fracture prevention in elderly postmenopausal women with osteoporosis aged over 75 and older. J Am Geriatr Soc 58:292-299
29. Gallagher JC, Genant HK, Crans GG et al (2005) Teriparatide reduces the fracture risk associated with increasing number and severity of osteoporotic, fractures. J Clin Endocrinol Metab 90(3):1583-1587
30. Boonen, et al (2006) Safety and efficacy of teriparatide in elderly women with established osteoporosis: bone anabolic therapy from a geriatric perspective. J Am Geriatr Soc 54:782-789
31. Meunier PJ, Roux C, Seeman E et al (2004) The effects of strontiumranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. SOTI study. N Engl J Med 350(5):459-468
32. Seaman E, Vellas B, Benhamou C et al (2006) Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older. J Bone Mnier Res 21:1113-1120
33. O'Donnell S, Cranney A, Wells GA et al (2006) Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane Database Syst Rev (4):CD005326
34. Cummings SR, San Martin J, McClung MR et al (2009) Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361(8):756-765
35. McClung MC, Boonen S, Törring O et al (2012) Effect of denosumab treatment in the risk of fractures in subgroups of women with postmenopausal osteoporosis. J Bone Miner Res 2(1):211-218
36. Boonen S, Adachi D, Man Z et al (2011) Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal woman at high risk. J Clin Endocrinol Metab 96(6):1727-1736
37. Sinaki M, Pfeifer M, Preisinger E et al (2010) The role of exercise in the treatment of osteoporosis. Curr Osteoporos Rep 8(3):138-144
38. Howe TE, Shea B, Dawson LJ et al (2011) Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane Database Syst Rev (7):CD000333
39. Nikander R, Sievänen H, Heinonen A et al (2010) Targeted exercise against osteoporosis: a systematic review and meta-analysis for optimising bone strength throughout life. BMC Med 8:47
40. Body JJ, Bergmann P, Boonen S et al (2011) Non-pharmacological management of osteoporosis: a consensus of the Belgian Bone Club. Osteoporos Int 22(11):2769-2788
41. Martyn-St James M, Carroll S (2010) Effects of different impact exercise modalities on bone mineral density in premenopausal women: a meta-analysis. J Bone Miner Metab 28(3):251-267
42. Martyn-St James M, Carroll S (2008) Meta-analysis of walking for preservation of bone mineral density in postmenopausal women. Bone 43(3):521-531
43. Hamilton CJ, Swan VJ, Jamal SA (2010) The effects of exercise and physical activity participation on bone mass and geometry in postmenopausal women: a systematic review of pQCT studies. Osteoporos Int 21(1):11-23
44. Boonen S, Wahl DA, Nauroy L et al (2011) Balloon kyphoplasty and vertebroplasty in the management of vertebral compression fractures. Osteoporos Int 22(12):2915-2934
45. Nakano M, Hirano N, Ishihara H et al (2006) Calcium phosphate cement-based vertebroplasty compared with conservative treatment for osteoporotic compression fractures: a matched case-control study. J Neurosurg Spine 4:110-117
46. Weisskopf M, Ohnsorge JA, Niethard FU (2008) Intravertebral pressure during vertebroplasty and balloon kyphoplasty: an in vitro study. Spine 33:1050.
47. Voggenreiter G (2005) Balloon kyphoplasty is effective in deformity correction of osteoporotic vertebral compression fractures. Spine 30:2806-2812
48. Hu SS (1997) Internal fixation in the osteoporotic spine. Spine 22:43S-48S
49. Krappinger D, Kastenberger TJ, Schmid R (2012) Die Behandlung osteoporotischer Wirbelkörperfrakturen mit augmentierter Instrumentation. Oper Orthop Traumatol 24:4-12
50. Anglen JO, Weinstein JN (2008) Nail or plate fixation of intertrochanteric hip fractures: changing pattern of practice. A review of the American Board of Orthopaedic Surgery Database. J Bone Joint Surg Am 90(4):700-707
51. Mattsson P, Larsson S (2004) Unstable trochanteric fractures augmented with calcium phosphate cement. A prospective randomized study using radiostereometry to measure fracture stability. Scand J Surg 93(3):223-228
52. Kammerlander C, Gebhard F, Meier C et al (2011) Standardised cement augmentation of the PFNA using a perforated blade: a new technique and preliminary clinical results. A prospective multicentre trial. Injury 42:1484-90.
53. Sermon A, Boner V, Boger A et al (2012) Potential of polymethylmethacrylate cement-augmented helical proximal femoral nail antirotation blades to improve implant stability-a biomechanical investigation in human cadaveric femoral heads. J Trauma Acute Care Surg 72(2):E54-59
54. Gates BJ, Sonnett TE, DuVall C et al (2009) Review of osteoporosis pharmacotherapy for geriatric patients. Am J Ger Pharm 7(6):293-323
55. Eriksen EF, Lyles KW, Clon-Emeric CS et al (2009) Antifracture efficacy and reduction of mortality in relation to timing of the first dose of zoledronic acid after hip fracture. J Bone Miner Res 24:1308-1313
56. Habermann B et al (2009) Strontium ranelate enhances callus strength more than PTH 1-34 in an osteoporotic rat model of fracture healing. Calcif Tissue Int 2010 86(1):82-89
57. Charlson ME, Pompei P, Ales K, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373-383
58. Schousboe JT et al (2005) Universal bone densitometry screening combined with alendrotnate therapy for those diagnosed with osteoporosis is highly cost-effective for elderly women. J Am Geriatr Soc 53(10):1697-1704
59. Bolland MJ, Grey AB, Gamble GD, Reid IR (2010) Effect of osteoporosis treatment on mortality: a meta-analysis. J Clin Endocrinol Metab:1174-1181
60. Zhu K, Austin N, Devine A et al (2010) A randomized controlled trial of the effect of Vitamin D on muscle strength and mobility in older women with vitamin D insufficiency. J Am Geriatr Soc 58:2063-2068
61. Autier P, Gandini S (2007) Vitamin supplementation and total mortality. A meta-analysis of randomized controlled trial. Arch Intern Med 167(16):1730-1737
62. Body JJ, Bergmann P, Boonen S et al (2012) Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications. Osteoporos Int 23(Suppl 1):1-23