Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Pal Bhadra, Manika ^a   Ramaiah, M J ^a,b   Reddy, T L ^a   Krishnan, Anita ^a,b   Pushpavalli, S N C V L ^a   Babu, K S ^a   Tiwari, Ashok K ^a   Rao, J M ^a   Yadav, Jhillu S ^a   Bhadra, Utpal ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

A375 cells; Apoptosis; Cell cycle arrest; Chrysin; Hdac inhibitor; Hdac 8; P21 promoter; P21waf1; Stat

Indexed keywords

CASPASE 3; CHRYSIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; HISTONE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; LUCIFERASE; METHOXYCHRYSIN; OROXYLIN A; OROXYLUM INDICUM EXTRACT; PLANT EXTRACT; PROTEIN BCL XL; PROTEIN P21; PROTEIN P27; PROTEIN P53; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; SURVIVIN; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALORIMETRY; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL VIABILITY; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CORRELATION ANALYSIS; DNA MODIFICATION; DRUG STRUCTURE; ENZYME ASSAY; ENZYME INHIBITION; FLOW CYTOMETRY; FLUOROMETRY; HISTONE ACETYLATION; HISTONE METHYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; OROXYLUM; PLANT STEM; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; WESTERN BLOTTING;

ACETYLATION; APOPTOSIS; BASE SEQUENCE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL NUCLEUS; CHROMOSOMES, HUMAN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FLAVONOIDS; GENE ORDER; HISTONE DEACETYLASE INHIBITORS; HISTONES; HUMANS; METHYLATION; PROMOTER REGIONS, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; RESPONSE ELEMENTS; STAT TRANSCRIPTION FACTORS;

EID: 84864354377     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-180     Document Type: Article

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