메뉴 건너뛰기




Volumn 7, Issue 7, 2012, Pages

Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; HLA DR ANTIGEN; KI 67 ANTIGEN; SILIBININ;

EID: 84864352463     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0041832     Document Type: Article
Times cited : (31)

References (46)
  • 2
    • 80855161172 scopus 로고    scopus 로고
    • Antigen-Dependent and -Independent Mechanisms of T and B Cell Hyperactivation during Chronic Hiv-1 Infection
    • Haas A, Zimmermann K, Oxenius A, (2011) Antigen-Dependent and-Independent Mechanisms of T and B Cell Hyperactivation during Chronic Hiv-1 Infection. Journal of virology.
    • (2011) Journal of Virology
    • Haas, A.1    Zimmermann, K.2    Oxenius, A.3
  • 3
    • 54849405132 scopus 로고    scopus 로고
    • Cellular and molecular interactions in coinfection with hepatitis C virus and human immunodeficiency virus
    • Roe B, Hall WW, (2008) Cellular and molecular interactions in coinfection with hepatitis C virus and human immunodeficiency virus. Expert Rev Mol Med 10: e30.
    • (2008) Expert Rev Mol Med , vol.10
    • Roe, B.1    Hall, W.W.2
  • 4
    • 79952705520 scopus 로고    scopus 로고
    • HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies
    • Operskalski EA, Kovacs A, (2011) HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies. Current HIV/AIDS reports 8: 12-22.
    • (2011) Current HIV/AIDS Reports , vol.8 , pp. 12-22
    • Operskalski, E.A.1    Kovacs, A.2
  • 5
    • 79953721940 scopus 로고    scopus 로고
    • Coinfection with human immunodeficiency virus and hepatitis C virus: challenges and therapeutic advances. Insights from the Society of Infectious Diseases Pharmacists
    • Deming P, McNicholl IR, (2011) Coinfection with human immunodeficiency virus and hepatitis C virus: challenges and therapeutic advances. Insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy 31: 357-368.
    • (2011) Pharmacotherapy , vol.31 , pp. 357-368
    • Deming, P.1    McNicholl, I.R.2
  • 6
    • 69549119129 scopus 로고    scopus 로고
    • Coinfection with HIV-1 and HCV-a one-two punch
    • Kim AY, Chung RT, (2009) Coinfection with HIV-1 and HCV-a one-two punch. Gastroenterology 137: 795-814.
    • (2009) Gastroenterology , vol.137 , pp. 795-814
    • Kim, A.Y.1    Chung, R.T.2
  • 7
    • 0035882187 scopus 로고    scopus 로고
    • Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis
    • Graham CS, Baden LR, Yu E, Mrus JM, Carnie J, et al. (2001) Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: a meta-analysis. Clin Infect Dis 33: 562-569.
    • (2001) Clin Infect Dis , vol.33 , pp. 562-569
    • Graham, C.S.1    Baden, L.R.2    Yu, E.3    Mrus, J.M.4    Carnie, J.5
  • 8
    • 37349032491 scopus 로고    scopus 로고
    • Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adults
    • Sulkowski MS, Mehta SH, Torbenson MS, Higgins Y, Brinkley SC, et al. (2007) Rapid fibrosis progression among HIV/hepatitis C virus-co-infected adults. AIDS 21: 2209-2216.
    • (2007) AIDS , vol.21 , pp. 2209-2216
    • Sulkowski, M.S.1    Mehta, S.H.2    Torbenson, M.S.3    Higgins, Y.4    Brinkley, S.C.5
  • 9
    • 0032837102 scopus 로고    scopus 로고
    • Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group
    • Benhamou Y, Bochet M, Di Martino V, Charlotte F, Azria F, et al. (1999) Liver fibrosis progression in human immunodeficiency virus and hepatitis C virus coinfected patients. The Multivirc Group. Hepatology 30: 1054-1058.
    • (1999) Hepatology , vol.30 , pp. 1054-1058
    • Benhamou, Y.1    Bochet, M.2    Di Martino, V.3    Charlotte, F.4    Azria, F.5
  • 10
    • 70350061700 scopus 로고    scopus 로고
    • Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus
    • Macias J, Berenguer J, Japon MA, Giron JA, Rivero A, et al. (2009) Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus. Hepatology 50: 1056-1063.
    • (2009) Hepatology , vol.50 , pp. 1056-1063
    • Macias, J.1    Berenguer, J.2    Japon, M.A.3    Giron, J.A.4    Rivero, A.5
  • 11
    • 39549094030 scopus 로고    scopus 로고
    • Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial
    • Seeff LB, Curto TM, Szabo G, Everson GT, Bonkovsky HL, et al. (2008) Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Hepatology 47: 605-612.
    • (2008) Hepatology , vol.47 , pp. 605-612
    • Seeff, L.B.1    Curto, T.M.2    Szabo, G.3    Everson, G.T.4    Bonkovsky, H.L.5
  • 13
    • 34247583381 scopus 로고    scopus 로고
    • Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin
    • Polyak SJ, Morishima C, Shuhart MC, Wang CC, Liu Y, et al. (2007) Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin. Gastroenterology 132: 1925-1936.
    • (2007) Gastroenterology , vol.132 , pp. 1925-1936
    • Polyak, S.J.1    Morishima, C.2    Shuhart, M.C.3    Wang, C.C.4    Liu, Y.5
  • 16
    • 33847265733 scopus 로고    scopus 로고
    • Silybin and silymarin-new and emerging applications in medicine
    • Gazak R, Walterova D, Kren V, (2007) Silybin and silymarin-new and emerging applications in medicine. Curr Med Chem 14: 315-338.
    • (2007) Curr Med Chem , vol.14 , pp. 315-338
    • Gazak, R.1    Walterova, D.2    Kren, V.3
  • 17
    • 75149191891 scopus 로고    scopus 로고
    • Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection
    • Morishima C, Shuhart MC, Wang CC, Paschal DM, Apodaca MC, et al. (2010) Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection. Gastroenterology 138: 671-681 681 e671-672.
    • (2010) Gastroenterology , vol.138 , pp. 671-681
    • Morishima, C.1    Shuhart, M.C.2    Wang, C.C.3    Paschal, D.M.4    Apodaca, M.C.5
  • 18
    • 77950530324 scopus 로고    scopus 로고
    • Multiple effects of silymarin on the hepatitis C virus lifecycle
    • Wagoner J, Negash A, Kane OJ, Martinez LE, Nahmias Y, et al. (2010) Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology 51: 1912-1921.
    • (2010) Hepatology , vol.51 , pp. 1912-1921
    • Wagoner, J.1    Negash, A.2    Kane, O.J.3    Martinez, L.E.4    Nahmias, Y.5
  • 19
    • 77449092252 scopus 로고    scopus 로고
    • Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase
    • Ahmed-Belkacem A, Ahnou N, Barbotte L, Wychowski C, Pallier C, et al. (2010) Silibinin and Related Compounds Are Direct Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase. Gastroenterology 138: 1112-1122.
    • (2010) Gastroenterology , vol.138 , pp. 1112-1122
    • Ahmed-Belkacem, A.1    Ahnou, N.2    Barbotte, L.3    Wychowski, C.4    Pallier, C.5
  • 20
    • 79551572739 scopus 로고    scopus 로고
    • Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation
    • Wagoner J, Morishima C, Graf TN, Oberlies NH, Teissier E, et al. (2011) Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation. PLoS One 6: e16464.
    • (2011) PLoS One , vol.6
    • Wagoner, J.1    Morishima, C.2    Graf, T.N.3    Oberlies, N.H.4    Teissier, E.5
  • 21
    • 55249084176 scopus 로고    scopus 로고
    • Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy
    • Ferenci P, Scherzer TM, Kerschner H, Rutter K, Beinhardt S, et al. (2008) Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy. Gastroenterology 135: 1561-1567.
    • (2008) Gastroenterology , vol.135 , pp. 1561-1567
    • Ferenci, P.1    Scherzer, T.M.2    Kerschner, H.3    Rutter, K.4    Beinhardt, S.5
  • 22
    • 77956649719 scopus 로고    scopus 로고
    • Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient
    • Payer BA, Reiberger T, Rutter K, Beinhardt S, Staettermayer AF, et al. (2010) Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient. J Clin Virol 49: 131-133.
    • (2010) J Clin Virol , vol.49 , pp. 131-133
    • Payer, B.A.1    Reiberger, T.2    Rutter, K.3    Beinhardt, S.4    Staettermayer, A.F.5
  • 23
    • 0037456827 scopus 로고    scopus 로고
    • Antibody neutralization and escape by HIV-1
    • Wei X, Decker JM, Wang S, Hui H, Kappes JC, et al. (2003) Antibody neutralization and escape by HIV-1. Nature 422: 307-312.
    • (2003) Nature , vol.422 , pp. 307-312
    • Wei, X.1    Decker, J.M.2    Wang, S.3    Hui, H.4    Kappes, J.C.5
  • 24
    • 0342506507 scopus 로고    scopus 로고
    • Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses
    • Vodicka MA, Goh WC, Wu LI, Rogel ME, Bartz SR, et al. (1997) Indicator cell lines for detection of primary strains of human and simian immunodeficiency viruses. Virology 233: 193-198.
    • (1997) Virology , vol.233 , pp. 193-198
    • Vodicka, M.A.1    Goh, W.C.2    Wu, L.I.3    Rogel, M.E.4    Bartz, S.R.5
  • 25
    • 0001206491 scopus 로고
    • Continuous Culture of Human Lymphoblasts from Peripheral Blood of a Child with Acute Leukemia
    • Foley GE, Lazarus H, Farber S, Uzman BG, Boone BA, et al. (1965) Continuous Culture of Human Lymphoblasts from Peripheral Blood of a Child with Acute Leukemia. Cancer 18: 522-529.
    • (1965) Cancer , vol.18 , pp. 522-529
    • Foley, G.E.1    Lazarus, H.2    Farber, S.3    Uzman, B.G.4    Boone, B.A.5
  • 26
    • 0025804107 scopus 로고
    • LAV revisited: origins of the early HIV-1 isolates from Institut Pasteur
    • Wain-Hobson S, Vartanian JP, Henry M, Chenciner N, Cheynier R, et al. (1991) LAV revisited: origins of the early HIV-1 isolates from Institut Pasteur. Science 252: 961-965.
    • (1991) Science , vol.252 , pp. 961-965
    • Wain-Hobson, S.1    Vartanian, J.P.2    Henry, M.3    Chenciner, N.4    Cheynier, R.5
  • 29
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • Reed LJ, Muench H, (1938) A simple method of estimating fifty percent endpoints. The American Journal of Hygiene 27: 493-497.
    • (1938) The American Journal of Hygiene , vol.27 , pp. 493-497
    • Reed, L.J.1    Muench, H.2
  • 30
    • 0036260635 scopus 로고    scopus 로고
    • HIV type 1 variants transmitted to women in Kenya require the CCR5 coreceptor for entry, regardless of the genetic complexity of the infecting virus
    • Long EM, Rainwater SM, Lavreys L, Mandaliya K, Overbaugh J, (2002) HIV type 1 variants transmitted to women in Kenya require the CCR5 coreceptor for entry, regardless of the genetic complexity of the infecting virus. AIDS research and human retroviruses 18: 567-576.
    • (2002) AIDS Research and Human Retroviruses , vol.18 , pp. 567-576
    • Long, E.M.1    Rainwater, S.M.2    Lavreys, L.3    Mandaliya, K.4    Overbaugh, J.5
  • 31
    • 0032992212 scopus 로고    scopus 로고
    • Variants from the diverse virus population identified at seroconversion of a clade A human immunodeficiency virus type 1-infected woman have distinct biological properties
    • Poss M, Overbaugh J, (1999) Variants from the diverse virus population identified at seroconversion of a clade A human immunodeficiency virus type 1-infected woman have distinct biological properties. Journal of virology 73: 5255-5264.
    • (1999) Journal of Virology , vol.73 , pp. 5255-5264
    • Poss, M.1    Overbaugh, J.2
  • 32
    • 80355131958 scopus 로고    scopus 로고
    • The role of amino acid changes in the human immunodeficiency virus type 1 transmembrane domain in antibody binding and neutralization
    • Lovelace E, Xu H, Blish CA, Strong R, Overbaugh J, (2011) The role of amino acid changes in the human immunodeficiency virus type 1 transmembrane domain in antibody binding and neutralization. Virology 421: 235-244.
    • (2011) Virology , vol.421 , pp. 235-244
    • Lovelace, E.1    Xu, H.2    Blish, C.A.3    Strong, R.4    Overbaugh, J.5
  • 33
    • 67650930740 scopus 로고    scopus 로고
    • Cross-subtype neutralization sensitivity despite monoclonal antibody resistance among early subtype A, C, and D envelope variants of human immunodeficiency virus type 1
    • Blish CA, Jalalian-Lechak Z, Rainwater S, Nguyen MA, Dogan OC, et al. (2009) Cross-subtype neutralization sensitivity despite monoclonal antibody resistance among early subtype A, C, and D envelope variants of human immunodeficiency virus type 1. Journal of virology 83: 7783-7788.
    • (2009) Journal of Virology , vol.83 , pp. 7783-7788
    • Blish, C.A.1    Jalalian-Lechak, Z.2    Rainwater, S.3    Nguyen, M.A.4    Dogan, O.C.5
  • 34
    • 34147180438 scopus 로고    scopus 로고
    • HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry
    • Blish CA, Nedellec R, Mandaliya K, Mosier DE, Overbaugh J, (2007) HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry. AIDS 21: 693-702.
    • (2007) AIDS , vol.21 , pp. 693-702
    • Blish, C.A.1    Nedellec, R.2    Mandaliya, K.3    Mosier, D.E.4    Overbaugh, J.5
  • 35
    • 33947600590 scopus 로고    scopus 로고
    • Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding
    • Rainwater SM, Wu X, Nduati R, Nedellec R, Mosier D, et al. (2007) Cloning and characterization of functional subtype A HIV-1 envelope variants transmitted through breastfeeding. Curr HIV Res 5: 189-197.
    • (2007) Curr HIV Res , vol.5 , pp. 189-197
    • Rainwater, S.M.1    Wu, X.2    Nduati, R.3    Nedellec, R.4    Mosier, D.5
  • 36
    • 33847254313 scopus 로고    scopus 로고
    • Granulocyte-monocyte colony-stimulating factor upregulates HIV-1 replication in monocyte-derived macrophages cultured at low density
    • McClure J, van't Wout AB, Tran T, Mittler JE, (2007) Granulocyte-monocyte colony-stimulating factor upregulates HIV-1 replication in monocyte-derived macrophages cultured at low density. Journal of acquired immune deficiency syndromes 44: 254-261.
    • (2007) Journal of Acquired Immune Deficiency Syndromes , vol.44 , pp. 254-261
    • McClure, J.1    van't Wout, A.B.2    Tran, T.3    Mittler, J.E.4
  • 37
    • 0037034863 scopus 로고    scopus 로고
    • Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis
    • Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R, (2002) Silibinin inhibits constitutive and TNFalpha-induced activation of NF-kappaB and sensitizes human prostate carcinoma DU145 cells to TNFalpha-induced apoptosis. Oncogene 21: 1759-1767.
    • (2002) Oncogene , vol.21 , pp. 1759-1767
    • Dhanalakshmi, S.1    Singh, R.P.2    Agarwal, C.3    Agarwal, R.4
  • 39
    • 47149093695 scopus 로고    scopus 로고
    • Antiviral effects of silymarin against hepatitis C: the jury is still out
    • Polyak SJ, Morishima C, Hawke R, (2008) Antiviral effects of silymarin against hepatitis C: the jury is still out. Hepatology 48: 345-346.
    • (2008) Hepatology , vol.48 , pp. 345-346
    • Polyak, S.J.1    Morishima, C.2    Hawke, R.3
  • 40
    • 84857133441 scopus 로고    scopus 로고
    • Past, Present, and Future of Entry Inhibitors as HIV Microbicides
    • Gibson RM, Arts EJ, (2012) Past, Present, and Future of Entry Inhibitors as HIV Microbicides. Current HIV research 10: 19-26.
    • (2012) Current HIV Research , vol.10 , pp. 19-26
    • Gibson, R.M.1    Arts, E.J.2
  • 42
    • 79961140522 scopus 로고    scopus 로고
    • Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition
    • von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, et al. (2011) Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell 146: 471-484.
    • (2011) Cell , vol.146 , pp. 471-484
    • von Kleist, L.1    Stahlschmidt, W.2    Bulut, H.3    Gromova, K.4    Puchkov, D.5
  • 43
    • 79951683184 scopus 로고    scopus 로고
    • Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C
    • author reply 592-593
    • Beinhardt S, Rasoul-Rockenschaub S, Scherzer TM, Ferenci P, (2011) Silibinin monotherapy prevents graft infection after orthotopic liver transplantation in a patient with chronic hepatitis C. Journal of hepatology 54: 591-592 author reply 592-593.
    • (2011) Journal of Hepatology , vol.54 , pp. 591-592
    • Beinhardt, S.1    Rasoul-Rockenschaub, S.2    Scherzer, T.M.3    Ferenci, P.4
  • 44
    • 77952426576 scopus 로고    scopus 로고
    • Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy
    • Neumann UP, Biermer M, Eurich D, Neuhaus P, Berg T, (2010) Successful prevention of hepatitis C virus (HCV) liver graft reinfection by silibinin mono-therapy. J Hepatol.
    • (2010) J Hepatol
    • Neumann, U.P.1    Biermer, M.2    Eurich, D.3    Neuhaus, P.4    Berg, T.5
  • 45
    • 0035859871 scopus 로고    scopus 로고
    • Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B
    • Gong G, Waris G, Tanveer R, Siddiqui A, (2001) Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B. Proc Natl Acad Sci U S A 98: 9599-9604.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9599-9604
    • Gong, G.1    Waris, G.2    Tanveer, R.3    Siddiqui, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.