Conscious perception of emotional stimuli: Brain mechanisms

Neuroscientist

Volumn 18, Issue 4, 2012, Pages 386-398

  Mitchell, Derek G V ^a   Greening, Steven G ^b  

^a WESTERN UNIVERSITY   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

amygdala; attention; consciousness; emotion; emotion regulation; emotional awareness; prefrontal cortex; visual awareness

Indexed keywords

ATTENTION; CONSCIOUSNESS; EMOTIONALITY; HUMAN; NERVE CELL NETWORK; PARIETAL CORTEX; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; STIMULUS RESPONSE; SUBCORTEX; VISUAL DISCRIMINATION; VISUAL STIMULATION;

ATTENTION; BRAIN; BRAIN MAPPING; CONSCIOUSNESS; EMOTIONS; HUMANS; MODELS, BIOLOGICAL; VISUAL PERCEPTION;

EID: 84864345355     PISSN: 10738584     EISSN: 10894098     Source Type: Journal    
DOI: 10.1177/1073858411416515     Document Type: Review

References (75)

1. Amaral DG, Behniea H, Kelly JL. Topographic organization of projections from the amygdala to the visual cortex in the macaque monkey. Neuroscience. 2003 ; 118 (4). 1099-120 (Pubitemid 36561197)
2. Amting JM, Greening SG, Mitchell DGV. Multiple mechanisms of consciousness: the neural correlates of emotional awareness. J Neurosci. 2010 ; 30 (20). 10039-47
3. Amting JM, Miller J, Chow M, Mitchell DGV. Getting mixed messages: the impact of conflicting social signals on the brain's target emotional response. NeuroImage. 2009 ; 47: 1950-9
4. Anderson AK, Phelps EA. Lesions of the human amygdala impair enhanced perception of emotionally salient events. Nature. 2001 ; 411 (6835). 305-9 (Pubitemid 32467035)
5. Baars BJ. The conscious access hypothesis: origins and recent evidence. Trends Cogn Sci. 2002 ; 6 (1). 47-52 (Pubitemid 34081846)
6. Bishop SJ, Duncan J, Lawrence AD. State anxiety modulation of the amygdala response to unattended threat-related stimuli. J Neurosci. 2004 ; 24 (46). 10364-8 (Pubitemid 39552620)
7. Bishop SJ, Jenkins R, Lawrence AD. Neural processing of fearful faces: effects of anxiety are gated by perceptual capacity limitations. Cereb Cortex. 2007 ; 17 (7). 1595-603
8. Crick F, Koch C. A framework for consciousness. Nat Neurosci. 2003 ; 6 (2). 119-26 (Pubitemid 36182780)
9. de Gelder B, Vroomen J, Pourtois G, Weiskrantz L. Non-conscious recognition of affect in the absence of striate cortex. Neuroreport. 1999 ; 10 (18). 3759-63 (Pubitemid 30004829)
10. Dehaene S, Artiges E, Naccache L, Martelli C, Viard A, Schurhoff F. Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: the role of the anterior cingulate. Proc Natl Acad Sci U S A. 2003 ; 100 (23). 13722-7 (Pubitemid 37444806)
11. Dehaene S, Changeux JP, Naccache L, Sackur J, Sergent C. Conscious, preconscious, and subliminal processing: a testable taxonomy. Trends Cogn Sci. 2006 ; 10 (5). 204-11 (Pubitemid 43674496)
12. Dehaene S, Naccache L, Cohen L, Bihan DL, Mangin JF, Poline JB, Riviere D. Cerebral mechanisms of word masking and unconscious repetition priming. Nat Neurosci. 2001 ; 4 (7). 752-8 (Pubitemid 32595415)
13. Del Cul A, Dehaene S, Reyes P, Bravo E, Slachevsky A. Causal role of prefrontal cortex in the threshold for access to consciousness. Brain. 2009 ; 132 (Pt 9). 2531-40
14. Delgado MR, Nearing KI, Ledoux JE, Phelps EA. Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron. 2008 ; 59 (5). 829-38
15. Desimone R, Duncan J. Neural mechanisms of selective visual attention. Annu Rev Neurosci. 1995 ; 18: 193-222
16. Dienes Z, Scott R. Measuring unconscious knowledge: distinguishing structural knowledge and judgment knowledge. Psychol Res. 2005 ; 69 (5-6). 338-51 (Pubitemid 40937371)
17. Dolan RJ, Vuilleumier P. Amygdala automaticity in emotional processing. Ann N Y Acad Sci. 2003 ; 985: 348-55 (Pubitemid 36521126)
18. Driver J, Mattingley JB. Parietal neglect and visual awareness. Nat Neurosci. 1998 ; 1 (1). 17-22 (Pubitemid 128652636)
19. Etkin A, Egner T, Peraza DM, Kandel ER, Hirsch J. Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron. 2006 ; 51 (6). 871-82 (Pubitemid 44376825)
20. Greening SG, Finger EC, Mitchell DG. Parsing decision making processes in prefrontal cortex: response inhibition, overcoming learned avoidance, and reversal learning. Neuroimage. 2011 ; 54 (2). 1432-41
21. Hamm AO, Weike AI, Schupp HT, Treig T, Dressel A, Kessler C. Affective blindsight: intact fear conditioning to a visual cue in a cortically blind patient. Brain. 2003 ; 126 (Pt 2). 267-75 (Pubitemid 36172734)
22. Kentridge RW, Heywood CA, Weiskrantz L. Attention without awareness in blindsight. Proc Biol Sci. 1999 ; 266 (1430). 1805-11 (Pubitemid 29433464)
23. Kentridge RW, Nijboer TC, Heywood CA. Attended but unseen: visual attention is not sufficient for visual awareness. Neuropsychologia. 2008 ; 46 (3). 864-9
24. Koch C, Tsuchiya N. Attention and consciousness: two distinct brain processes. Trends Cogn Sci. 2007 ; 11 (1). 16-22 (Pubitemid 46001614)
25. Kouider S, Dehaene S. Levels of processing during non-conscious perception: a critical review of visual masking. Philos Trans R Soc Lond B Biol Sci. 2007 ; 362 (1481). 857-75 (Pubitemid 47056815)
26. LeDoux JE, Sakaguchi A, Reis DJ. Subcortical efferent projections of the medial geniculate nucleus mediate emotional responses conditioned to acoustic stimuli. J Neurosci. 1984 ; 4 (3). 683-98 (Pubitemid 14127179)
27. Leopold DA, Logothetis NK. Activity changes in early visual cortex reflect monkeys' percepts during binocular rivalry. Nature. 1996 ; 379 (6565). 549-53 (Pubitemid 26049583)
28. Leopold DA, Logothetis NK. Multistable phenomena: changing views in perception. Trends Cogn Sci. 1999 ; 3 (7). 254-64 (Pubitemid 29314518)
29. Lumer ED, Rees G. Covariation of activity in visual and prefrontal cortex associated with subjective visual perception. Proc Natl Acad Sci U S A. 1999 ; 96 (4). 1669-73 (Pubitemid 29098509)
30. Merikle PM, Smilek D, Eastwood JD. Perception without awareness: perspectives from cognitive psychology. Cognition. 2001 ; 79 (1-2). 115-34 (Pubitemid 32054798)
31. Milad MR, Quirk GJ. Neurons in medial prefrontal cortex signal memory for fear extinction. Nature. 2002 ; 420 (6911). 70-4 (Pubitemid 35291441)
32. Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry. 2007 ; 62 (5). 446-54 (Pubitemid 47284021)
33. Mitchell DG. The nexus between decision making and emotion regulation: a review of convergent neurocognitive substrates. Behav Brain Res. 2011 ; 217 (1). 215-31
34. Mitchell DG, Luo Q, Avny SB, Kasprzycki T, Gupta K, Chen G. Adapting to dynamic stimulus-response values: differential contributions of inferior frontal, dorsomedial, and dorsolateral regions of prefrontal cortex to decision making. J Neurosci. 2009 ; 29 (35). 10827-34
35. Mitchell DG, Luo Q, Mondillo K, Vythilingam M, Finger EC, Blair RJ. The interference of operant task performance by emotional distracters: an antagonistic relationship between the amygdala and frontoparietal cortices. Neuroimage. 2008 ; 40 (2). 859-68
36. Mitchell DGV, Nakic M, Fridberg D, Kamel N, Pine DS, Blair RJR. The impact of processing load on emotion. NeuroImage. 2007 ; 34: 1299-309 (Pubitemid 46084854)
37. Morris JS, DeGelder B, Weiskrantz L, Dolan RJ. Differential extrageniculostriate and amygdala responses to presentation of emotional faces in a cortically blind field. Brain. 2001 ; 124 (Pt 6). 1241-52 (Pubitemid 32510391)
38. Morris JS, Friston KJ, Buchel C, Frith CD, Young AW, Calder AJ, Dolan RJ. A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain. 1998 ; 121 (Pt 1). 47-57 (Pubitemid 28045505)
39. Morris JS, Ohman A, Dolan RJ. A subcortical pathway to the right amygdala mediating "unseen" fear. Proc Natl Acad Sci U S A. 1999 ; 96 (4). 1680-5 (Pubitemid 29098511)
40. Overgaard M, Fehl K, Mouridsen K, Bergholt B, Cleeremans A. Seeing without seeing? Degraded conscious vision in a blindsight patient. PLoS One. 2008 ; 3 (8). e3028
41. Pascual-Leone A, Walsh V. Fast backprojections from the motion to the primary visual area necessary for visual awareness. Science. 2001 ; 292 (5516). 510-2 (Pubitemid 32335955)
42. Pegna AJ, Khateb A, Lazeyras F, Seghier ML. Discriminating emotional faces without primary visual cortices involves the right amygdala. Nat Neurosci. 2005 ; 8 (1). 24-5 (Pubitemid 41236727)
43. Persaud N, McLeod P, Cowey A. Post-decision wagering objectively measures awareness. Nat Neurosci. 2007 ; 10 (2). 257-61 (Pubitemid 46174851)
44. Pessoa L, Adolphs R. Emotion processing and the amygdala: from a 'low road' to 'many roads' of evaluating biological significance. Nat Rev Neurosci. 2010 ; 11 (11). 773-83
45. Pessoa L, Japee S, Sturman D, Ungerleider LG. Target visibility and visual awareness modulate amygdala responses to fearful faces. Cereb Cortex. 2006 ; 16 (3). 366-75 (Pubitemid 43209211)
46. Pessoa L, Japee S, Ungerleider LG. Visual awareness and the detection of fearful faces. Emotion. 2005a ; 5 (2). 243-7 (Pubitemid 40993315)
47. Pessoa L, McKenna M, Gutierrez E, Ungerleider LG. Neural processing of emotional faces requires attention. Proc Natl Acad Sci U S A. 2002 ; 99 (17). 11458-63 (Pubitemid 34920947)
48. Pessoa L, Padmala S, Morland T. Fate of unattended fearful faces in the amygdala is determined by both attentional resources and cognitive modulation. Neuroimage. 2005b ; 28 (1). 249-55 (Pubitemid 41393904)
49. Phelps EA, Delgado MR, Nearing KI, LeDoux JE. Extinction learning in humans: role of the amygdala and vmPFC. Neuron. 2004 ; 43 (6). 897-905 (Pubitemid 39215019)
50. Rees G, Wojciulik E, Clarke K, Husain M, Frith C, Driver J. Unconscious activation of visual cortex in the damaged right hemisphere of a parietal patient with extinction. Brain. 2000 ; 123 (Pt 8). 1624-33 (Pubitemid 30481186)
51. Reynolds JH, Chelazzi L, Desimone R. Competitive mechanisms subserve attention in macaque areas V2 and V4. J Neurosci. 1999 ; 19 (5). 1736-53 (Pubitemid 29094192)
52. Sahraie A, Hibbard PB, Trevethan CT, Ritchie KL, Weiskrantz L. Consciousness of the first order in blindsight. Proc Natl Acad Sci U S A. 2010 ; 107 (49). 21217-22
53. Seth AK, Dienes Z, Cleeremans A, Overgaard M, Pessoa L. Measuring consciousness: relating behavioural and neurophysiological approaches. Trends Cogn Sci. 2008 ; 12 (8). 314-21
54. Stoerig P, Barth E. Low-level phenomenal vision despite unilateral destruction of primary visual cortex. Conscious Cogn. 2001 ; 10 (4). 574-87 (Pubitemid 34095214)
55. Sumner P, Tsai PC, Yu K, Nachev P. Attentional modulation of sensorimotor processes in the absence of perceptual awareness. Proc Natl Acad Sci U S A. 2006 ; 103 (27). 10520-5 (Pubitemid 44051199)
56. Szczepanowski R. Absence of advantageous wagering does not mean that awareness is fully abolished. Conscious Cogn. 2010 ; 19 (1). 426-31
57. Szczepanowski R, Pessoa L. Fear perception: can objective and subjective awareness measures be dissociated?. J Vis. 2007 ; 7 (4). 10
58. Tamietto M, de Gelder B. Neural bases of the non-conscious perception of emotional signals. Nat Rev Neurosci. 2010 ; 11 (10). 697-709
59. Tamietto M, Geminiani G, Genero R, de Gelder B. Seeing fearful body language overcomes attentional deficits in patients with neglect. J Cogn Neurosci. 2007 ; 19 (3). 445-54 (Pubitemid 46393572)
60. Tong F, Nakayama K, Vaughan JT, Kanwisher N. Binocular rivalry and visual awareness in human extrastriate cortex. Neuron. 1998 ; 21 (4). 753-9 (Pubitemid 28498784)
61. Tsushima Y, Sasaki Y, Watanabe T. Greater disruption due to failure of inhibitory control on an ambiguous distractor. Science. 2006 ; 314 (5806). 1786-8 (Pubitemid 44969092)
62. Vuilleumier P, Armony JL, Clarke K, Husain M, Driver J, Dolan RJ. Neural response to emotional faces with and without awareness: event-related fMRI in a parietal patient with visual extinction and spatial neglect. Neuropsychologia. 2002 ; 40 (12). 2156-66
63. Vuilleumier P, Armony JL, Driver J, Dolan RJ. Effects of attention and emotion on face processing in the human brain: an event-related fMRI study. Neuron. 2001a ; 30 (3). 829-41 (Pubitemid 32607346)
64. Vuilleumier P, Sagiv N, Hazeltine E, Poldrack RA, Swick D, Rafal RD, Gabrieli JD. Neural fate of seen and unseen faces in visuospatial neglect: a combined event-related functional MRI and event-related potential study. Proc Natl Acad Sci U S A. 2001b ; 98 (6). 3495-500 (Pubitemid 32220873)
65. Vuilleumier P, Schwartz S. Beware and be aware: capture of spatial attention by fear-related stimuli in neglect. Neuroreport. 2001a ; 12 (6). 1119-22 (Pubitemid 32374728)
66. Vuilleumier P, Schwartz S. Emotional facial expressions capture attention. Neurology. 2001b ; 56 (2). 153-8 (Pubitemid 32095353)
67. Vuilleumier P, Schwartz S, Verdon V, Maravita A, Hutton C, Husain M, Driver J. Abnormal attentional modulation of retinotopic cortex in parietal patients with spatial neglect. Curr Biol. 2008 ; 18 (19). 1525-9
68. Weiskrantz L Consciousness Lost and Found: A Neuropsychological Exploration. Oxford: Oxford University Press ; 1997 :
69. Weiskrantz L, Barbur JL, Sahraie A. Parameters affecting conscious versus unconscious visual discrimination with damage to the visual cortex (V1). Proc Natl Acad Sci U S A. 1995 ; 92 (13). 6122-6
70. Weiskrantz L, Cowey A, Hodinott-Hill I. Prime-sight in a blindsight subject. Nat Neurosci. 2002 ; 5 (2). 101-2 (Pubitemid 34121575)
71. Whalen PJ, Kagan J, Cook RG, Davis FC, Kim H, Polis S. Human amygdala responsivity to masked fearful eye whites. Science. 2004 ; 306 (5704). 2061 (Pubitemid 40007651)
72. Whalen PJ, Rauch SL, Etcoff NL, McInerney SC, Lee MB, Jenike MA. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci. 1998 ; 18 (1). 411-8 (Pubitemid 28046798)
73. Williams LM, Liddell BJ, Kemp AH, Bryant RA, Meares RA, Peduto AS, Gordon E. Amygdala-prefrontal dissociation of subliminal and supraliminal fear. Hum Brain Mapp. 2006 ; 27 (8). 652-61 (Pubitemid 44182454)
74. Williams MA, McGlone F, Abbott DF, Mattingley JB. Differential amygdala responses to happy and fearful facial expressions depend on selective attention. Neuroimage. 2005 ; 24 (2). 417-25 (Pubitemid 41359037)
75. Zeki S, Ffytche DH. The Riddoch syndrome: insights into the neurobiology of conscious vision. Brain. 1998 ; 121 (Pt 1). 25-45 (Pubitemid 28045504)