Enhancement of dendritic cell activation via CD40 ligand-expressing γδ T cells is responsible for protective immunity to Plasmodium parasites

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 30, 2012, Pages 12129-12134

  Inoue, Shin Ichi ^a   Niikura, Mamoru ^a   Takeo, Satoru ^a   Mineo, Shoichiro ^a   Kawakami, Yasushi ^b   Uchida, Akihiko ^b   Kamiya, Shigeru ^a   Kobayashi, Fumie ^a  

^a KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AZABU UNIVERSITY   (Japan)

Author keywords

Immunotherapeutic approaches; Innate lymphocytes

Indexed keywords

CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; GAMMA INTERFERON; INTERLEUKIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CELL ACTIVATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEATH; DENDRITIC CELL; GAMMA DELTA T LYMPHOCYTE; HYBRIDOMA CELL CULTURE; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T CELL DEPLETION; TH1 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; CD40 LIGAND; CYTOKINES; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; INTERFERON-GAMMA; MALARIA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PARASITEMIA; PLASMODIUM BERGHEI; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES;

MUS; PLASMODIUM BERGHEI; PLASMODIUM PARASITES;

EID: 84864336883     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204480109     Document Type: Article

References (35)

1. Bonneville M, O'Brien RL, Born WK (2010) γδ T cell effector functions: A blend of innate programming and acquired plasticity. Nat Rev Immunol 10:467-478.
2. Hiromatsu K, et al. (1992) A protective role of γ/δ T cells in primary infection with Listeria monocytogenes in mice. J Exp Med 175:49-56.
3. + T cells during experimental infection of mice with Leishmania major. J Immunol 150:550-555.
4. Hisaeda H, et al. (1995) γδ T cells play an important role in hsp65 expression and in acquiring protective immune responses against infection with Toxoplasma gondii. J Immunol 155:244-251.
5. Wang T, et al. (2006) γδ T cells facilitate adaptive immunity against West Nile virus infection in mice. J Immunol 177:1825-1832. (Pubitemid 44092520)
6. - phenotype in the liver. Immunology 117:127-135.
7. Dieli F, Troye-Blomberg M, Farouk SE, Sireci G, Salerno A (2001) Biology of γδ T cells in tuberculosis and malaria. Curr Mol Med 1:437-446.
8. Nakazawa S, Brown AE, Maeno Y, Smith CD, Aikawa M (1994) Malaria-induced increase of splenic γδ T cells in humans, monkeys, and mice. Exp Parasitol 79:391-398. (Pubitemid 24359898)
9. Kobayashi F, et al. (2007) Plasmodium berghei XAT: Contribution of γδ T cells to host defense against infection with blood-stage nonlethal malaria parasite. Exp Parasitol 117:368-375. (Pubitemid 350050951)
10. Waki S, Tamura J, Imanaka M, Ishikawa S, Suzuki M (1982) Plasmodium berghei: Isolation and maintenance of an irradiation attenuated strain in the nude mouse. Exp Parasitol 53:335-340. (Pubitemid 12015628)
11. Waki S, et al. (1992) The role of T cells in pathogenesis and protective immunity to murine malaria. Immunology 75:646-651.
12. Yoneto T, et al. (1999) Gamma interferon production is critical for protective immunity to infection with blood-stage Plasmodium berghei XAT but neither NO production nor NK cell activation is critical. Infect Immun 67:2349-2356. (Pubitemid 29200492)
13. von der Weid T, Kopf M, Köhler G, Langhorne J (1994) The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice. Eur J Immunol 24:2285-2293. (Pubitemid 24303067)
14. Trinchieri G (1995) Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13:251-276.
15. + T cells. J Immunol 154:5071-5079.
16. Cella M, et al. (1996) Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 184:747-752. (Pubitemid 26324129)
17. Schulz O, et al. (2000) CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13:453-462.
18. + T cells and the recognition of MHC class I molecules. Immunology 89:405-412.
19. van der Heyde HC, et al. (1995) γδ T cells function in cell-mediated immunity to acute blood-stage Plasmodium chabaudi adami malaria. J Immunol 154:3985-3990.
20. + T cell and antibody response during a primary Plasmodium chabaudi chabaudi infection in mice. Parasite Immunol 24:131-140.
21. Wykes MN, et al. (2007) Plasmodium strain determines dendritic cell function essential for survival from malaria. PLoS Pathog 3:e96.
22. Koch F, et al. (1996) High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med 184:741-746. (Pubitemid 26324128)
23. Engwerda CR, Beattie L, Amante FH (2005) The importance of the spleen in malaria. Trends Parasitol 21:75-80. (Pubitemid 40138879)
24. Albert ML, et al. (1998) Immature dendritic cells phagocytose apoptotic cells via αβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med 188:1359-1368. (Pubitemid 28478024)
25. Urban BC, Ing R, Stevenson MM (2005) Early interactions between blood-stage plasmodium parasites and the immune system. Curr Top Microbiol Immunol 297:25-70. (Pubitemid 41383377)
26. Stevenson MM, Riley EM (2004) Innate immunity to malaria. Nat Rev Immunol 4:169-180. (Pubitemid 38339083)
27. Elloso MM, van der Heyde HC, vande Waa JA, Manning DD, Weidanz WP (1994) Inhibition of Plasmodium falciparum in vitro by human γδ T cells. J Immunol 153:1187-1194.
28. Farouk SE, Mincheva-Nilsson L, Krensky AM, Dieli F, Troye-Blomberg M (2004) γδ T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway that requires granulysin. Eur J Immunol 34:2248-2256. (Pubitemid 39256106)
29. Fang H, et al. (2010) γδ T cells promote the maturation of dendritic cells during West Nile virus infection. FEMS Immunol Med Microbiol 59:71-80.
30. Shi C, et al. (2011) Reduced immune response to Borrelia burgdorferi in the absence of γδ T cells. Infect Immun 79:3940-3946.
31. + T cells in the expansion of the CD4-, CD8- γδ T cell subset in the spleens of mice during blood-stage malaria. J Immunol 151:6311-6317.
32. Okamoto Yoshida Y, et al. (2010) Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol 184:4414-4422.
33. Hamada S, et al. (2008) IL-17A produced by γδ T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver. J Immunol 181:3456-3463.
34. Jameson J, et al. (2002) A role for skin γδ T cells in wound repair. Science 296:747-749. (Pubitemid 34442005)
35. Langhorne J, Mombaerts P, Tonegawa S (1995) αβ and γδ T cells in the immune response to the erythrocytic stages of malaria in mice. Int Immunol 7:1005-1011.